Results 91 to 100 of about 851,389 (262)

Sphingolipid Metabolism and Signaling in Endothelial Cell Functions

, 2022
The endothelium, inner layer of blood vessels, constitutes a metabolically active paracrine, endocrine, and autocrine organ, able to sense the neighboring environment and exert a variety of biological functions important to preserve the health of ...
Sasset, Linda, Di Lorenzo, Annarita
core   +1 more source

Entry of muscle satellite cells into the cell cycle requires sphingolipid signaling [PDF]

, 2006
Adult skeletal muscle is able to repeatedly regenerate because of the presence of satellite cells, a population of stem cells resident beneath the basal lamina that surrounds each myofiber.
Matsuda, R, Yosuke Nagata, Terence A. Partridge, Ryoichi Matsuda, Zammit, P S, Nagata, Y, Partridge, T A, Peter S. Zammit   +7 more
core   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

DKC1 promotes colorectal cancer progression and therapy resistance by dysregulating sphingolipid biosynthesis

Nature Communications
DKC1, a key coordinator of RNA modification and telomerase activity, has been implicated in colorectal cancer (CRC), yet its role in disease pathogenesis remains incompletely understood.
Umar K. Khan, Ayush Goel, Shivansh Nigam, Nazia Chaudhary, Ayush Praveen, Anjan Roy, Fabeha Fatima, Dilpreet K. Sawhney, Afiya Dalwai, Akshay Shendre, Shannon Carskadon, Anjali Bajpai, Abhimanyu Kapoor, Anjali Tewari, Abhijit Chandra, Avanish Saklani, Sorab N. Dalal, Nallasivam Palanisamy, Bushra Ateeq   +18 more
doaj   +1 more source

Sphingolipid-mediated Signalling in Plants, [PDF]

Annals of Botany, 2001
A plethora of biological effects, ranging from cellular survival to apoptosis, has been assigned to sphingolipids and, in particular, to the sphingolipid metabolites ceramide, sphingosine and sphingosine-1-phosphate. One aspect of sphingolipid biology that is currently attracting a great deal of interest in animals and yeast is their role in cell ...
openaire   +1 more source

From apex to base: Uncovering spatial metabolic adaptation in Antarctic mosses

Bulletin of the Korean Chemical Society, EarlyView.
Antarctic mosses survive extreme cold, desiccation, UV exposure, and oxidative stress. We analyzed three species by separating apical, middle, and basal zones. Each zone showed distinct metabolite patterns and biological roles, revealing spatial metabolic specialization. The results suggest that whole‐plant survival depends on coordinated contributions
Fatima Tuz Zahra, Yelim Lee, Hyoungseok Lee, Amancio de Souza, Manhoi Hur, Katayoon Dehesh, Jungeun Lee, Sunghwan Kim   +7 more
wiley   +1 more source

Regulation of sphingolipid metabolism in the immune microenvironment of gastric cancer: current insights and future directions

Frontiers in Oncology
In recent years, the role of sphingolipid metabolism in the tumor immune microenvironment has gradually gained attention, particularly in gastric cancer research.
Yunqi Hua, Gangling Zhang, Yubo Liu, Xiaoling Tian, Xinyi Zhang, Ge Song, Qinggang Tian, Fangrui Yin   +7 more
doaj   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Analysis of sphingolipid-signaling at the plasma membrane of Saccharomyces cerevisiae [PDF]

, 2010
The protein and lipid composition of eukaryotic plasma membranes is highly dynamic and regulated according to need. Despite its great plasticity, the plasma membrane retains some organizational features, such as its lateral organization into distinct ...
Fröhlich, Florian
core   +1 more source

Sphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degenerative Disorders

Frontiers in Neuroscience, 2018
Neurodegenerative diseases represent a class of fatal brain disorders for which the number of effective therapeutic options remains limited with only symptomatic treatment accessible. Multiple studies show that defects in sphingolipid pathways are shared
Alba Di Pardo, Vittorio Maglione
doaj   +1 more source