Results 81 to 90 of about 851,389 (262)

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Liu Shen Wan regulates the SPHK1/S1P axis to ameliorate influenza-induced inflammation via integrated network pharmacology and lipidomics

Frontiers in Immunology
BackgroundLiu Shen Wan (LSW) can modulate sphingolipid metabolism, which is a key pathway in inflammatory regulation, yet the precise mechanistic actions remain elusive.
Biao Lei, Biao Lei, Zhenyang Liu, Peifang Xie, Xuanxuan Li, Zhanyu Cui, Ruihan Chen, Bin Liu, Shihua Chen, Yaxin Li, Min Liang, Hao Liang, Ai Li, Fanghao Zheng, Zifeng Yang, Qinhai Ma   +15 more
doaj   +1 more source

Neutral sphingomyelinase-3 mediates TNF-stimulated oxidant activity in skeletal muscle

Redox Biology, 2014
Aims: Sphingolipid and oxidant signaling affect glucose uptake, atrophy, and force production of skeletal muscle similarly and both are stimulated by tumor necrosis factor (TNF), suggesting a connection between systems.
Jennifer S. Moylan, Jeffrey D. Smith, Erin M. Wolf Horrell, Julie B. McLean, Gergana M. Deevska, Mark R. Bonnell, Mariana N. Nikolova-Karakashian, Michael B. Reid   +7 more
doaj   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

The Sphingolipid Long-chain Base-Pkh1/2-Ypk1/2 Signaling Pathway Regulates Eisosome Assembly and Turnover

, 2008
Udgivelsesdato: Apr-18Eisosomes are recently described fungal structures that play roles in the organization of the plasma membrane and endocytosis. Their major protein components are Pil1 and Lsp1, and previous studies showed that these proteins are ...
Liu, Ying, Guangzuo Luo, Albrecht Gruhler, Jensen, Ole Nørregaard; id_orcid, Ying Liu, Gruhler, Albrecht, Dickson, Robert C, Robert C. Dickson, Ole N. Jensen, Luo, Guangzuo   +9 more
core   +1 more source

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, EarlyView.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source

ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity via the ATF4–SPTLC1 axis

Frontiers in Pharmacology
BackgroundCocaine-induced endoplasmic reticulum (ER) stress has been increasingly recognized, but its neuronal specificity and functional significance remain unclear.
Yue Zhao, Shu Li, Linhong Jiang, Ying Zhao, Weihong Kuang, Qingfan Wei, Yuanyi Zhou, Shuang Han, Liang Wang, Hongchun Li, Yanping Dai, Xiaofeng Yang, Siqi Xu, Feng Qin, Rong Chen, Yaxing Chen, Chunqi Liu, Qian Bu, Bo Chen, Bin Liu, Meng Qin, Yinglan Zhao, Xiaobo Cen   +22 more
doaj   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster

Journal of Lipid Research, 2004
Sphingolipid metabolites function as signaling molecules in mammalian cells, influencing cell proliferation, migration, and death. Recently, sphingolipid signaling has been implicated in the regulation of developmental processes in Drosophila ...
Henrik Fyrst, Deron R. Herr, Greg L. Harris, Julie D. Saba   +3 more
doaj   +1 more source

Hepatocyte-Derived Lipotoxic Extracellular Vesicle Sphingosine 1-Phosphate Induces Macrophage Chemotaxis

Frontiers in Immunology, 2018
Background: The pathophysiology of non-alcoholic steatohepatitis involves hepatocyte lipotoxicity due to excess saturated free fatty acids and concomitant proinflammatory macrophage effector responses.
Chieh-Yu Liao, Myeong Jun Song, Yandong Gao, Amy S. Mauer, Alexander Revzin, Harmeet Malhi   +5 more
doaj   +1 more source