Results 41 to 50 of about 851,389 (262)
PLoS Genetics, 2020 Sphingolipids are abundant and essential molecules in eukaryotes that have crucial functions as signaling molecules and as membrane components. Sphingolipid biosynthesis starts in the endoplasmic reticulum with the condensation of serine and palmitoyl ...
Bianca M Esch +10 more
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The pleiotropic roles of sphingolipid signaling in autophagy [PDF]
Cell Death Dis, 2014 The autophagic process involves encompassing damaged proteins and organelles within double- or multi-membraned structures and delivering these molecules to the lytic compartments of vacuoles. Sphingolipids (SLs), which are ubiquitous membrane lipids in eukaryotes, participate in the generation of various membrane structures, including rafts, caveolae ...
Li Y +6 more
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The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei [PDF]
, 2010 Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K. +2 more
core +1 more source
Membrane Contact Sites in Yeast: Control Hubs of Sphingolipid Homeostasis
Membranes, 2021 Sphingolipids are the most diverse class of membrane lipids, in terms of their structure and function. Structurally simple sphingolipid precursors, such as ceramides, act as intracellular signaling molecules in various processes, including apoptosis ...
Philipp Schlarmann +2 more
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Journal of Lipid Research, 2022 Sphingosine-1-phosphate (S1P) is a sphingolipid metabolite that serves as a potent extracellular signaling molecule. Metabolic regulation of extracellular S1P levels impacts key cellular activities through altered S1P receptor signaling.
Mari Kono +6 more
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Production of α-galactosylceramide by a prominent member of the human gut microbiota. [PDF]
PLoS Biology, 2013 While the human gut microbiota are suspected to produce diffusible small molecules that modulate host signaling pathways, few of these molecules have been identified.
Laura C Wieland Brown +9 more
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Sphingolipids and Signal Transduction.
membrane, 1996 Sphingolipids that are ubiquitous constituents of membrane lipids in mammalian cells are essential for cell growth. Various sphingolipids have been implicated to function as modulators in signaling pathways. Recently, regulated hydrolysis of sphingomyelin to generate ceramide was suggested to play bifurcate roles in cellular response to tumor-necrosis ...
Hanada, Kentaro, Nishijima, Masahiro
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Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
eLife, 2021 Sphingolipids are important structural components of cell membranes and prominent signaling molecules controlling cell growth, differentiation, and apoptosis.
Wei Fan +9 more
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Journal of the American Society of Nephrology, 1996 Glycerophospholipids have long been recognized as substrates for the formation of important intracellular second messengers. Recently, another class of membrane-associated lipids, sphingolipids, has been identified as potentially important in cell-signaling events.
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