Results 21 to 30 of about 851,389 (262)
Sphingolipid signaling in kidney diseases. [PDF]
Am J Physiol Renal PhysiolSphingolipids are a family of bioactive lipids. The key components include ceramides, ceramide-1-phosphate, sphingosine, and sphingosine-1-phosphate. Sphingolipids were originally considered to be primarily structural elements of cell membranes but were later recognized as bioactive signaling molecules that play diverse roles in cellular behaviors such
Li N, Li G.
europepmc +3 more sources
Recent Insights into the Interplay of Alpha-Synuclein and Sphingolipid Signaling in Parkinson's Disease. [PDF]
Int J Mol Sci, 2021 Molecular studies have provided increasing evidence that Parkinson’s disease (PD) is a protein conformational disease, where the spread of alpha-synuclein (ASN) pathology along the neuraxis correlates with clinical disease outcome.
Motyl JA +3 more
europepmc +2 more sources
Inflammatory Ocular Diseases and Sphingolipid Signaling. [PDF]
Adv Exp Med Biol, 2019 Inflammation is a powerful immune countermeasure to tissue damage and infection. The inflammatory response is complex and requires the involvement of myriad signaling pathways and metabolic processes, all governed by a multitude of regulatory systems. Although inflammation is a vital defense against tissue injury and a necessary step in tissue healing,
Grambergs R, Mondal K, Mandal N.
europepmc +4 more sources
Thematic Review Series: Sphingolipids. Nuclear sphingolipids: metabolism and signaling [PDF]
Journal of Lipid Research, 2008 Sphingolipids are most prominently expressed in the plasma membrane, but recent studies have pointed to important signaling and regulatory roles in the nucleus. The most abundant nuclear sphingolipid is sphingomyelin (SM), which occurs in the nuclear envelope (NE) as well as intranuclear sites.
Robert W. Ledeen, Gusheng Wu
openaire +5 more sources
Role of Sphingolipid Signaling in Glomerular Diseases: Focus on DKD and FSGS. [PDF]
J Cell Signal, 2020 Sphingolipids are well-recognized as major players in the pathogenesis of many human diseases, including chronic kidney disease. The kidney is a very sensitive organ to alterations in sphingolipid metabolism.
Mitrofanova A +3 more
europepmc +2 more sources
Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells : role of sphingosine kinase 1 and S1P lyase [PDF]
, 2011 Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P(1) receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade.
Gorshkova, Irina +9 more
core +4 more sources
Sphingolipids in plant immunity
Phytopathology Research, 2022 Sphingolipids (lipids with a sphingoid base backbone) are important components of eukaryotic membrane systems and key signaling molecules that are essential for controlling cellular homeostasis, acclimating to stress, and regulating plant immunity ...
Hong-Yun Zeng, Nan Yao
doaj +1 more source
Bile acids and sphingolipids in non-alcoholic fatty liver disease
Chinese Medical Journal, 2022 . Non-alcoholic fatty liver disease (NAFLD) is one of the fastest-growing diseases, and its global prevalence is estimated to increase >50% by 2030. NAFLD is comorbid with metabolic syndrome, obesity, type 2 diabetes, and insulin resistance.
Kaitlyn G. Jackson +3 more
doaj +1 more source
Fumonisin B1: A Tool for Exploring the Multiple Functions of Sphingolipids in Plants
Frontiers in Plant Science, 2020 Fumonisin toxins are produced by Fusarium fungal pathogens. Fumonisins are structural analogs of sphingosine and potent inhibitors of ceramide synthases (CerSs); they disrupt sphingolipid metabolism and cause disease in plants and animals.
Hong-Yun Zeng, Chun-Yu Li, Nan Yao
doaj +1 more source
Journal of Veterinary Internal Medicine, 2021 Background Sphingolipids modulate insulin sensitivity in mammals. Increased synthesis of ceramides is linked to decreased insulin sensitivity of tissues.
Yue Hei Leung +4 more
doaj +1 more source