Results 1 to 10 of about 32,407 (113)

Pathway analysis of peripheral blood CD8+ T cell transcriptome shows differential regulation of sphingolipid signaling in multiple sclerosis and glioblastoma. [PDF]

PLoS ONE
Multiple sclerosis (MS) and glioblastoma (GBM) are CNS diseases in whose development and progression immune privilege is intimately important, but in a relatively opposite manner. Maintenance and strengthening of immune privilege have been shown to be an
Milan Stefanović, Ivan Jovanović, Maja Živković, Aleksandra Stanković   +3 more
doaj   +2 more sources

The p53–CerS6 interaction on the ER integrates p53 and sphingolipid signaling pathways in metabolic stress response [PDF]

Journal of Lipid Research
Ceramides, a diverse class of bioactive sphingolipids, play a pivotal role in cellular stress response. We have previously reported a novel mechanism by which a particular member of this class, C16-ceramide, activates death pathways in cancer cells.
Madeline S. Childress, Kristen A. Jeffries, David A. Horita, Sergey A. Krupenko, Natalia I. Krupenko   +4 more
doaj   +2 more sources

Podocyte Sphingolipid Signaling in Nephrotic Syndrome [PDF]

Cellular Physiology and Biochemistry, 2021
Guangbi Li, Jason Kidd, Todd W.B. Gehr, Pin-Lan Li   +3 more
doaj   +2 more sources

Sphingolipid metabolism and hematologic disorders: current understanding and future directions [PDF]

Frontiers in Physiology
Sphingolipids are not only key structural components of cell membranes but also serve as important signaling molecules, and their metabolic homeostasis is essential for the maintenance of cellular functions.
Zheshu Kuang, Tianjun Huang, Guanjun Chen   +2 more
doaj   +2 more sources

The Role of Sphingolipid Signaling in Oxidative Lung Injury and Pathogenesis of Bronchopulmonary Dysplasia [PDF]

International Journal of Molecular Sciences, 2022
Tara Sudhadevi, Anantha Harijith, Viswanathan Natarajan   +2 more
exaly   +2 more sources

Intercellular sphingolipid signaling mediates aversive learning in C. elegans [PDF]

Current Biology
Chun-Liang Pan, Chien-Po Liao
exaly   +2 more sources

Sphingolipid metabolism is associated with osteosarcoma metastasis and prognosis: Evidence from interaction analysis

Frontiers in Endocrinology, 2022
BackgroundMetabolism is widely involved in the occurrence and development of cancer. However, its role in osteosarcoma (OS) has not been elucidated.MethodsThe open-accessed data included in this study were downloaded from The Cancer Genome Atlas (TCGA ...
Xinyue Hu, Xin Zhou, Jue Zhang, Liangliang Li   +3 more
doaj   +1 more source

The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy

Nature Communications, 2023
Sphingolipids are ubiquitous components of membranes and function as bioactive lipid signaling molecules. Here, through genetic screening and lipidomics analyses, we find that the endoplasmic reticulum (ER) calcium channel Csg2 integrates sphingolipid ...
Shiyan Liu, Mutian Chen, Yichang Wang, Yuqing Lei, Ting Huang, Yabin Zhang, Sin Man Lam, Huihui Li, Shiqian Qi, Jia Geng, Kefeng Lu   +10 more
doaj   +1 more source

Using BODIPY FL-Sphingolipid Analogs to Study Sphingolipid Metabolism in Mouse Embryonic Stem Cells

Bio-Protocol, 2022
Sphingolipids are important structural components of cellular membranes. They also function as prominent signaling molecules to control a variety of cellular events, such as cell growth, differentiation, and apoptosis.
Wei Fan, Xiaoling Li
doaj   +1 more source

Correlating Basal Gene Expression across Chemical Sensitivity Data to Screen for Novel Synergistic Interactors of HDAC Inhibitors in Pancreatic Carcinoma

Pharmaceuticals, 2023
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies. Development of the chemoresistance in the PDAC is one of the key contributors to the poor survival outcomes and the major reason for urgent development of ...
Nemanja Djokovic, Ana Djuric, Dusan Ruzic, Tatjana Srdic-Rajic, Katarina Nikolic   +4 more
doaj   +1 more source