Results 91 to 100 of about 41,788 (297)

An unraveled mystery: What's the role of brain sphingolipids in neurodegenerative and psychiatric disorders

Neurobiology of Disease
Sphingolipids are a class of lipids highly expressed in brain, especially in the myelin sheath of white matter. In recent years, with the development of lipidomics, the role of brain sphingolipids in neurological disorders have raised lots of interests ...
Xintian Bie, Maoxing Zhang, Qingyu Wang, Ying Wang   +3 more
doaj   +1 more source

Sphingolipids and plant defense/disease: the "death" connection and beyond

Frontiers in Plant Science, 2012
Sphingolipids comprise a major class of structural materials and lipid signaling molecules in all eukaryotic cells. Over the past two decades, there has been a phenomenal growth in the study of sphingolipids (i.e.
Robert eBerkey, Dipti eBendigeri, Shunyuan eXiao, Shunyuan eXiao   +3 more
doaj   +1 more source

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Analysis of urinary sphingolipids using liquid chromatography‐tandem mass spectrometry in diabetic nephropathy

Journal of Diabetes Investigation, 2020
Aims/Introduction Sphingolipids, such as ceramides and sphingosine, are involved in the pathogenesis of diabetes; however, the modulation of urinary sphingolipids in diabetic nephropathy has not been fully elucidated.
Yoshifumi Morita, Makoto Kurano, Eri Sakai, Takako Nishikawa, Masako Nishikawa, Motoji Sawabe, Junken Aoki, Yutaka Yatomi   +7 more
doaj   +1 more source

Metabolic pathways of sphingolipids.

, 2014
The sphingolipids examined in this study comprise the core components of sphingolipid metabolism.
Su-Jun Zheng (469183), Feng Qu (107909), Cai-Sheng Wu (107912), Shuang Liu (8449), Zhong-Ping Duan (469184), Jin-Lan Zhang (107920)   +5 more
core   +1 more source

Dietary Sphingolipids Contribute to Health via Intestinal Maintenance

, 2021
As sphingolipids are constituents of the cell and vacuole membranes of eukaryotic cells, they are a critical component acquired from our daily diets. In the present review, we highlight the knowledge regarding how dietary sphingolipids affect our health,
Mikio Kinoshita, Shinji Yamashita, Teruo Miyazawa   +2 more
core   +1 more source

The role of sphingolipids in multi-organ lipotoxicity in metabolic syndrome. [PDF]

openThe global incidence of metabolic dysfunction–associated steatohepatitis (MASH) and heart failure with preserved ejection fraction (HFpEF) is rising due to the increasing prevalence of metabolic syndrome (MetS).
VOISIN, MARGOT DANIELLE
core  

The role and function of sphingolipids in glioblastoma multiforme

, 2015
Aberrations in sphingolipid metabolism and thus levels have been implicated in promoting the aggressiveness of glioblastoma multiforme, one of the most lethal cancers in humans.
G. Marfia, R. Campanella, Loubna Abdel Hadi, Stefania Elena Navone, Rolando Campanella, L. Abdel Hadi, Giovanni Marfia, Laura Riboni, L. Riboni, Clara Di Vito, S. Navone, C. Di Vito   +11 more
core   +1 more source

Optical Control of Glycerolipids and Sphingolipids

, 2021
Glycerolipids, Sphingolipids, and Sterols are the three major classes of membrane lipids. Both glycerolipids and sphingolipids are comprised of combinations of polar headgroups and fatty acid tails.
Morstein, Johannes, Trauner, Dirk
core   +1 more source