Results 161 to 170 of about 81,593 (273)
Human mesenchymal stem cells conditionally secrete sonic hedgehog (SHH)‐containing extra‐large extracellular vesicles (XLEVs) upon PI3K activation, which enriches the GDP‐bound form of Rab18. Rab18‐GDP drives perinuclear maturation and polarized vertical release of SHH‐XLEVs via Hsp90α‐ and nSMase2‐dependent mechanisms.
Shuo Wang +3 more
wiley +1 more source
Lipidomic and proteomic analysis revealed large‐scale differences in the midgut composition of the honeybee Apis mellifera and the buff‐tailed bumblebee Bombus terrestris. These differences correlated to increased insecticide absorption in the bumblebee when using an ex vivo Ussing chamber and subsequently in vivo feeding assay (created in Biorender ...
Emmanouil Kokkas +7 more
wiley +1 more source
Involvement of the sphingomyelin pathway in autocrine tumor necrosis factor signaling for human immunodeficiency virus production in chronically infected HL-60 cells [PDF]
CI Rivas +3 more
openalex +1 more source
Isolation and characterization of proteolipids from rat liver (LSP) and kidney (KSP) [PDF]
Blumenstingl, J. +2 more
core +1 more source
Lifespan‐Extending Endogenous Metabolites
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley +1 more source
Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco +6 more
wiley +1 more source
Asymmetric Phase Diagram of a Three Component Model Membrane Mixture Containing Sphingomyelin: Coupling of Lateral and Transverse Lipid Organization [PDF]
Aaron Frederick, Frederick A. Heberle
openalex +1 more source
Abstract Background Lycium barbarum polysaccharide (LBP) has long been recognized as having a wide range of beneficial properties for improving proliferation. However, the protective effects and specific mechanisms of d‐galactose‐induced testicular dysfunction in reproductively senescent rats are not fully understood.
Wenxin Ma +8 more
wiley +1 more source
Challenge Specific Modulation of Responses to Adjuvant‐Induced Innate Immune Memory
We utilised a commercially available adjuvant formulation to study the induction, maintenance, and consequences of innate immune memory. Using functional assays on bone marrow‐derived innate cells, extensive transcriptomic analysis of haematopoietic progenitors, and challenge models of spirochetal infection, nonspecific inflammation, and model antigen ...
Samuel T. Pasco +24 more
wiley +1 more source

