Results 11 to 20 of about 52,176 (275)

Lovastatin reversed the enhanced sphingomyelin caused by 27-hydroxycholesterol in cultured vascular endothelial cells

Biochemistry and Biophysics Reports, 2016
Statins have pleiotropic properties which are involved in inhibiting the thrombogenic response. In this study, the effects of lovastatin on two phospholipids, phosphatidylcholine and sphingomyelin, were studied in cultured endothelial cells in the ...
Qi Zhou, Allan Luo, Fred A Kummerow
doaj   +1 more source

Metabolism of sphingolipids by normal and atherosclerotic aorta of squirrel monkeys

Journal of Lipid Research, 1970
We studied the synthesis and hydrolysis of sphingomyelin by homogenates of aortic intima plus inner media from normal squirrel monkeys and from monkeys with nutritionally-induced atherosclerosis (6-10 mo on a semi-purified diet containing butter and ...
O.W. Portman, M. Alexander
doaj   +1 more source

Sphingomyelin and progression of renal and coronary heart disease in individuals with type 1 diabetes

Diabetologia, 2020
Lipid abnormalities are associated with diabetic kidney disease and CHD, although their exact role has not yet been fully explained. Sphingomyelin, the predominant sphingolipid in humans, is crucial for intact glomerular and endothelial function ...
D. Pongrac Barlovič, V. Harjutsalo, N. Sandholm, C. Forsblom, P. Groop   +4 more
semanticscholar   +1 more source

Regulation of the threshold for lipoprotein-induced acyl-CoA:cholesterol O-acyltransferase stimulation in macrophages by cellular sphingomyelin content.

Journal of Lipid Research, 1994
Macrophage acyl-CoA:cholesterol O-acyltransferase (ACAT), a key enzyme in atheroma foam cell formation, is stimulated by lipoproteins only after a “threshold” amount of cholesterol has accumulated in the cell.
A.K. Okwu, X.X. Xu, Y. Shiratori, I. Tabas   +3 more
doaj   +1 more source

Ceramide/Sphingomyelin Rheostat Regulated by Sphingomyelin Synthases and Chronic Diseases in Murine Models

Journal of Lipid and Atherosclerosis, 2020
Ceramide and sphingomyelin (SM) are major components of the double membrane-bound sphingolipids. Ceramide is an essential bioactive lipid involved in numerous cell processes including apoptosis, necrosis, and autophagy-dependent cell death. Inversely, SM
M. Taniguchi, T. Okazaki
semanticscholar   +1 more source

Localization of nuclear actin in nuclear lipid microdomains of liver and hepatoma cells: Possible involvement of sphingomyelin metabolism

The EuroBiotech Journal, 2017
Nuclear actin has been implicated in different nuclear functions. In this work, its localization in nuclear membrane, chromatin and nuclear lipid microdomains was investigated. The implication of sphingomyelin metabolism was studied.
Cataldi Samuela, Lazzarini Andrea, Codini Michela, Cascianelli Giacomo, Floridi Alessandro, Bartoccini Elisa, Ceccarini Maria Rachele, Ambesi-Impiombato Francesco Saverio, Beccari Tommaso, Curcio Francesco, Albi Elisabetta   +10 more
doaj   +1 more source

Effects of Sphingomyelin-Containing Milk Phospholipids on Skin Hydration in UVB-Exposed Hairless Mice

Molecules, 2022
Reactive oxygen species (ROS) generated by ultraviolet (UV) exposure cause skin barrier dysfunction, which leads to dry skin. In this study, the skin moisturizing effect of sphingomyelin-containing milk phospholipids in UV-induced hairless mice was ...
Yejin Ahn, Min Guk Kim, Kyungae Jo, Ki-Bae Hong, Hyung Joo Suh   +4 more
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

Molecular Psychiatry, 2018
Major depressive disorder (MDD) is a common and severe disease characterized by mood changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the molecular mechanism of their action is unknown.
Anne Gulbins, F. Schumacher, K. A. Becker, B. Wilker, Matthias Soddemann, F. Boldrin, C. Müller, M. Edwards, Michael Goodman, C. Caldwell, B. Kleuser, J. Kornhuber, I. Szabó, E. Gulbins   +13 more
semanticscholar   +1 more source

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro[S]

Journal of Lipid Research, 2020
Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases.
Eyad Naser, Stephanie Kadow, Fabian Schumacher, Zainelabdeen H. Mohamed, Christian Kappe, Gabriele Hessler, Barbara Pollmeier, Burkhard Kleuser, Christoph Arenz, Katrin Anne Becker, Erich Gulbins, Alexander Carpinteiro   +11 more
doaj   +1 more source