Localization of nuclear actin in nuclear lipid microdomains of liver and hepatoma cells: Possible involvement of sphingomyelin metabolism [PDF]
The EuroBiotech Journal, 2017 Nuclear actin has been implicated in different nuclear functions. In this work, its localization in nuclear membrane, chromatin and nuclear lipid microdomains was investigated. The implication of sphingomyelin metabolism was studied.
Cataldi Samuela +10 more
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Lipid Signature of Motile Human Sperm: Characterization of Sphingomyelin, Ceramide, and Phospholipids with a Focus on Very Long Chain Polyunsaturated Fatty Acids. [PDF]
Int J Mol SciOresti GM, Luquez JM, Belmonte SA.
europepmc +3 more sources
Sphingomyelin regulates astrocyte activity by regulating NF-κB signaling via HDAC1/3 expression
Journal of Lipid ResearchAstrocytes comprise approximately 40% of CNS cells and have pivotal roles in brain functions. Under steady-state conditions, astrocytes maintain homeostasis in the CNS through the uptake or release of neurotransmitters.
Ryo Kadowaki +4 more
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Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
eLife, 2022 Sphingomyelin is a dominant sphingolipid in mammalian cells. Its production in the trans-Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol gradient along the secretory pathway.
Tolulope Sokoya +16 more
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The nutritional functions of dietary sphingomyelin and its applications in food
Frontiers in Nutrition, 2022 Sphingolipids are common structural components of cell membranes and are crucial for cell functions in physiological and pathophysiological conditions.
Fang Yang, Guoxun Chen
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Sphingomyelin in Human Breast Milk might be Essential for the Hippocampus Maturation
Frontiers in Bioscience-Landmark, 2022 Background: It has been established that sphingomyelin present human breast milk is useful for the brain maturation and cognitive development. At 10 days of breastfeeding the sphingomyelin content is double that present in cow’s milk and its content is ...
Elisabetta Albi +15 more
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Nature Communications, 2023 Although the human immunodeficiency virus type 1 lipid envelope has been reported to be enriched with host cell sphingomyelin and cholesterol, the molecular mechanism of the enrichment is not well understood.
Nario Tomishige +9 more
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The Multiple Roles of Sphingomyelin in Parkinson’s Disease
Biomolecules, 2021 Advances over the past decade have improved our understanding of the role of sphingolipid in the onset and progression of Parkinson’s disease. Much attention has been paid to ceramide derived molecules, especially glucocerebroside, and little on ...
Paola Signorelli +2 more
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Biochemistry and Biophysics Reports, 2016 Statins have pleiotropic properties which are involved in inhibiting the thrombogenic response. In this study, the effects of lovastatin on two phospholipids, phosphatidylcholine and sphingomyelin, were studied in cultured endothelial cells in the ...
Qi Zhou, Allan Luo, Fred A Kummerow
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Doxorubicin Affects Testicular Lipids with Long-Chain (C18-C22) and Very Long-Chain (C24-C32) Polyunsaturated Fatty Acids [PDF]
, 2007 Doxorubicin disrupts spermatogenesis by causing apoptosis of spermatogonia and primary spermatocytes. The aim of this study was to examine the effect of this agent on adult rat testicular lipids and their fatty acids.
Aveldaño, Marta Isabel +2 more
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