Results 11 to 20 of about 50,004 (207)

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Localization of nuclear actin in nuclear lipid microdomains of liver and hepatoma cells: Possible involvement of sphingomyelin metabolism

The EuroBiotech Journal, 2017
Nuclear actin has been implicated in different nuclear functions. In this work, its localization in nuclear membrane, chromatin and nuclear lipid microdomains was investigated. The implication of sphingomyelin metabolism was studied.
Cataldi Samuela, Lazzarini Andrea, Codini Michela, Cascianelli Giacomo, Floridi Alessandro, Bartoccini Elisa, Ceccarini Maria Rachele, Ambesi-Impiombato Francesco Saverio, Beccari Tommaso, Curcio Francesco, Albi Elisabetta   +10 more
doaj   +1 more source

Membrane properties of sphingomyelins [PDF]

FEBS Letters, 2002
Sphingomyelin and phosphatidylcholine are important components in the external leaflet of cellular plasma membranes. In this review we compare the structure of these lipid molecules, with emphasis on the differences in hydrogen bonding capacity and membrane properties that arise from the small but significant differences in molecular structure.
Ramstedt, Bodil, Slotte, J.Peter
openaire   +2 more sources

Human Plasma Sphingomyelins.

Experimental Biology and Medicine, 1964
SummaryThe sphingomyelin region of human plasma lipids, entirely free from lecithin, has been fractionated into two components by thin-layer chromatography. Both components had properties characteristic of sphingomyelins, but markedly different fatty acid patterns, acids above C20 being concentrated in the less-polar material.
P D, WOOD, S, HOLTON
openaire   +2 more sources

Depletion of Host and Viral Sphingomyelin Impairs Influenza Virus Infection

Frontiers in Microbiology, 2020
Influenza A virus (IAV) is a major human respiratory pathogen causing annual epidemics as well as periodic pandemics. A complete understanding of the virus pathogenesis and host factors involved in the viral lifecycle is crucial for developing novel ...
Amani Audi, Amani Audi, Nadia Soudani, Nadia Soudani, Nadia Soudani, Ghassan Dbaibo, Ghassan Dbaibo, Ghassan Dbaibo, Hassan Zaraket, Hassan Zaraket   +9 more
doaj   +1 more source

Sphingomyelin synthase overexpression increases cholesterol accumulation and decreases cholesterol secretion in liver cells

Lipids in Health and Disease, 2011
Background Studies have shown that plasma high density lipoprotein cholesterol levels are negatively correlated with the development of atherosclerosis, whereas epidemiological studies have also shown that plasma sphingomyelin level is an independent ...
Li Yue, Dong Jibin, Ding Tingbo, Yan Nianlong, Wu Manping   +4 more
doaj   +1 more source

A lipid analogue that inhibits sphingomyelin hydrolysis and synthesis, increases ceramide, and leads to cell death

Journal of Lipid Research, 2005
We report the synthesis and characterization of a novel thiourea derivative of sphingomyelin (AD2765). In vitro assays using pure enzyme and/or cell extracts revealed that this compound inhibited the hydrolysis of BODIPY-conjugated or 14C-labeled ...
Peter I. Darroch, Arie Dagan, Tami Granot, Xingxuan He, Shimon Gatt, Edward H. Schuchman   +5 more
doaj   +1 more source

Morphological and functional status of liver at rats having toxic hepatites during injections of the liposomes loaded by sphingomyelin or ceramide

Бюллетень сибирской медицины, 2005
At inflammation process development caused by CCl4 morphological and functional research of 200 rats liver tissue was carried out. The liposomes loaded by the components of a sphingomyelin lipid cycle – sphingomyelin and ceramide were administed.
R. Z. Zainagetdinov, V. A. Zavarzin, I. L. Purlik, S. V. Novitsky, V. Yu. Serebrov   +4 more
doaj   +1 more source

Raft-based sphingomyelin interactions revealed by new fluorescent sphingomyelin analogs [PDF]

Journal of Cell Biology, 2017
Sphingomyelin (SM) has been proposed to form cholesterol-dependent raft domains and sphingolipid domains in the plasma membrane (PM). How SM contributes to the formation and function of these domains remains unknown, primarily because of the scarcity of suitable fluorescent SM analogs.
Masanao Kinoshita, Kenichi G.N. Suzuki, Nobuaki Matsumori, Misa Takada, Hikaru Ano, Kenichi Morigaki, Mitsuhiro Abe, Asami Makino, Toshihide Kobayashi, Koichiro M. Hirosawa, Takahiro K. Fujiwara, Akihiro Kusumi, Michio Murata   +12 more
openaire   +2 more sources

25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells.

Journal of Lipid Research, 1995
In several experimental and pathological conditions the cellular concentrations of cholesterol and sphingomyelin (SM) change coordinately. In an effort to identify factors mediating co-regulation, a class of suppressors of cholesterol synthesis ...
N D Ridgway
doaj   +1 more source