Results 21 to 30 of about 52,176 (275)

Sphingomyelin synthase overexpression increases cholesterol accumulation and decreases cholesterol secretion in liver cells

Lipids in Health and Disease, 2011
Background Studies have shown that plasma high density lipoprotein cholesterol levels are negatively correlated with the development of atherosclerosis, whereas epidemiological studies have also shown that plasma sphingomyelin level is an independent ...
Li Yue, Dong Jibin, Ding Tingbo, Yan Nianlong, Wu Manping   +4 more
doaj   +1 more source

Sphingomyelin in Brain and Cognitive Development: Preliminary Data

eNeuro, 2019
Sphingomyelin (SM) supports brain myelination, a process closely associated with cognitive maturation. The presence of SM in breast milk suggests a role in infant nutrition; however, little is known about SM contribution to healthy cognitive development.
N. Schneider, J. Hauser, Manuel Oliveira, E. Cazaubon, Sara Colombo Mottaz, B. O’Neill, P. Steiner, Sean C. L. Deoni   +7 more
semanticscholar   +1 more source

A lipid analogue that inhibits sphingomyelin hydrolysis and synthesis, increases ceramide, and leads to cell death

Journal of Lipid Research, 2005
We report the synthesis and characterization of a novel thiourea derivative of sphingomyelin (AD2765). In vitro assays using pure enzyme and/or cell extracts revealed that this compound inhibited the hydrolysis of BODIPY-conjugated or 14C-labeled ...
Peter I. Darroch, Arie Dagan, Tami Granot, Xingxuan He, Shimon Gatt, Edward H. Schuchman   +5 more
doaj   +1 more source

Morphological and functional status of liver at rats having toxic hepatites during injections of the liposomes loaded by sphingomyelin or ceramide

Бюллетень сибирской медицины, 2005
At inflammation process development caused by CCl4 morphological and functional research of 200 rats liver tissue was carried out. The liposomes loaded by the components of a sphingomyelin lipid cycle – sphingomyelin and ceramide were administed.
R. Z. Zainagetdinov, V. A. Zavarzin, I. L. Purlik, S. V. Novitsky, V. Yu. Serebrov   +4 more
doaj   +1 more source

25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells.

Journal of Lipid Research, 1995
In several experimental and pathological conditions the cellular concentrations of cholesterol and sphingomyelin (SM) change coordinately. In an effort to identify factors mediating co-regulation, a class of suppressors of cholesterol synthesis ...
N D Ridgway
doaj   +1 more source

Alterations of Sphingolipid and Phospholipid Pathways and Ornithine Level in the Plasma as Biomarkers of Parkinson’s Disease

Cells, 2022
The biomarkers of Parkinson’s disease (PD) remain to be investigated. This work aimed to identify blood biomarkers for PD using targeted metabolomics analysis.
Kuo-Hsuan Chang, Mei-Ling Cheng, Hsiang-Yu Tang, Cheng-Yu Huang, Hsiu-Chuan Wu, Chiung-Mei Chen   +5 more
doaj   +1 more source

Sphingomyelin synthase 2 promotes an aggressive breast cancer phenotype by disrupting the homoeostasis of ceramide and sphingomyelin

Cell Death and Disease, 2019
Breast cancer is the most common type of carcinoma in women worldwide, but the mechanisms underlying tumour development and progression remain unclear. Sphingomyelin synthase 2 (SGMS2) is a crucial regulator involved in ceramide (Cer) and sphingomyelin ...
Kehong Zheng, Zetao Chen, Haizhan Feng, Ying Chen, Cheng Zhang, Jinlong Yu, Yunfeng Luo, Liang Zhao, Xiancheng Jiang, Fujun Shi   +9 more
semanticscholar   +1 more source

Changes in Serum Sphingomyelin After Roux-en-Y Gastric Bypass Surgery Are Related to Diabetes Status

Frontiers in Endocrinology, 2018
Metabolic surgery is superior to lifestyle intervention in reducing weight and lowering glycemia and recently suggested as treatment for type 2 diabetes mellitus.
Elin Rebecka Carlsson, Josefine Liv Gilling Grundtvig, Sten Madsbad, Mogens Fenger   +3 more
doaj   +1 more source

Optimization of Giant Unilamellar Vesicle Electroformation for Phosphatidylcholine/Sphingomyelin/Cholesterol Ternary Mixtures

Membranes, 2022
Artificial vesicles are important tools in membrane research because they enable studying membrane properties in controlled conditions. Giant unilamellar vesicles (GUVs) are specially interesting due to their similarity in size to eukaryotic cells.
Zvonimir Boban, Ivan Mardešić, Witold Karol Subczynski, Dražan Jozić, Marija Raguz   +4 more
doaj   +1 more source

Raft-based sphingomyelin interactions revealed by new fluorescent sphingomyelin analogs

Journal of Cell Biology, 2017
Sphingomyelin (SM) has been proposed to form cholesterol-dependent raft domains and sphingolipid domains in the plasma membrane (PM). How SM contributes to the formation and function of these domains remains unknown, primarily because of the scarcity of ...
M. Kinoshita, Kenichi G. N. Suzuki, N. Matsumori, M. Takada, Hikaru Ano, K. Morigaki, M. Abe, A. Makino, Toshihide Kobayashi, Koichiro M. Hirosawa, T. Fujiwara, A. Kusumi, M. Murata   +12 more
semanticscholar   +1 more source