Results 31 to 40 of about 52,176 (275)

Unbiased Lipidomic Profiling of Triple-Negative Breast Cancer Tissues Reveals the Association of Sphingomyelin Levels with Patient Disease-Free Survival

Metabolites, 2018
The reprogramming of lipid metabolism is a hallmark of many cancers that has been shown to promote breast cancer progression. While several lipid signatures associated with breast cancer aggressiveness have been identified, a comprehensive lipidomic ...
Preeti Purwaha, Franklin Gu, Danthasinghe Waduge Badrajee Piyarathna, Theckelnaycke Rajendiran, Anindita Ravindran, Angela R. Omilian, Sao Jiralerspong, Gokul Das, Carl Morrison, Christine Ambrosone, Cristian Coarfa, Nagireddy Putluri, Arun Sreekumar   +12 more
doaj   +1 more source

A Single Sphingomyelin Species Promotes Exosomal Release of Endoglin into the Maternal Circulation in Preeclampsia

Scientific Reports, 2017
Preeclampsia (PE), an hypertensive disorder of pregnancy, exhibits increased circulating levels of a short form of the auxillary TGF-beta (TGFB) receptor endoglin (sENG). Until now, its release and functionality in PE remains poorly understood.
L. Ermini, Jonathan Ausman, M. Melland-Smith, B. Yeganeh, A. Rolfo, M. Litvack, T. Todros, M. Letarte, M. Post, I. Caniggia   +9 more
semanticscholar   +1 more source

The impact of sphingomyelin on the pathophysiology and treatment response to olipudase alfa in acid sphingomyelinase deficiency

Genetics in Medicine Open
Acid sphingomyelinase deficiency (ASMD) is a rare progressive genetic disorder caused by pathogenic variants in the SMPD1 gene causing low or absent activity of the enzyme acid sphingomyelinase, resulting in subsequent accumulation of its substrate ...
Monica Kumar, Mario Aguiar, Andreas Jessel, Beth L. Thurberg, Lisa Underhill, Holly Wong, Kelly George, Vanessa Davidson, Edward H. Schuchman   +8 more
doaj   +1 more source

Biosynthesis and metabolic degradation of sphingolipids not containing sialic acid

Journal of Lipid Research, 1972
Interest in sphingolipid metabolism has increased rapidly during the past decade, and many of the steps involved in the biosynthesis and metabolic degradation of sphingolipids are now known. In this review these studies are critically exmined.
Pierre Morell, Peter Braun
doaj   +1 more source

Depletion of Host and Viral Sphingomyelin Impairs Influenza Virus Infection

Frontiers in Microbiology, 2020
Influenza A virus (IAV) is a major human respiratory pathogen causing annual epidemics as well as periodic pandemics. A complete understanding of the virus pathogenesis and host factors involved in the viral lifecycle is crucial for developing novel ...
Amani Audi, Amani Audi, Nadia Soudani, Nadia Soudani, Nadia Soudani, Ghassan Dbaibo, Ghassan Dbaibo, Ghassan Dbaibo, Hassan Zaraket, Hassan Zaraket   +9 more
doaj   +1 more source

Sphingolipids and cholesterol modulate membrane susceptibility to cytosolic phospholipase A2

Journal of Lipid Research, 2000
Modulation of cytosolic phospholipase A2 (cPLA2) activity by sphingomyelin (SPH), ceramide (Cer), and cholesterol (Chol) was investigated in CHO-2B cells activated by the calcium ionophore A23187 and epinephrine.
Elsa Klapisz, Joëlle Masliah, Gilbert Béréziat, Claude Wolf, Kamen S. Koumanov   +4 more
doaj   +1 more source

Sphingomyelin is sorted at the trans Golgi network into a distinct class of secretory vesicle

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance The biochemical reactions that drive cellular life are housed in distinct membrane enclosed compartments known as organelles. Whereas proteins targeting to different organelles are well developed, little is known regarding how lipids are ...
Yongqiang Deng, F. Rivera-Molina, D. Toomre, C. Burd   +3 more
semanticscholar   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Sphingomyelin is involved in regulating UCP1-mediated nonshivering thermogenesis

Journal of Lipid Research
Adipogenesis is one of the major mechanisms for adipose tissue expansion, during which spindle-shaped mesenchymal stem cells commit to the fate of adipocyte precursors and differentiate into round-shaped fat-laden adipocytes.
Detian Hu, Houyu Zhang, Zhen Liu, Carlos F. Ibáñez, Cai Tie, Meng Xie   +5 more
doaj   +1 more source

Different rates of flux through the biosynthetic pathway for long-chain versus very-long-chain sphingolipids

Journal of Lipid Research, 2020
The backbone of all sphingolipids (SLs) is a sphingoid long-chain base (LCB) to which a fatty acid is N-acylated. Considerable variability exists in the chain length and degree of saturation of both of these hydrophobic chains, and recent work has ...
Iris D. Zelnik, Giora Volpert, Leena E. Viiri, Dimple Kauhanen, Tamar Arazi, Katriina Aalto-Setälä, Reijo Laaksonen, Anthony H. Futerman   +7 more
doaj   +1 more source