Results 141 to 150 of about 36,200 (174)

Alkaline sphingomyelinase (ENPP7) attenuates DSS-induced colitis by modulating FOXO1-mediated antioxidative stress responses. [PDF]

BMC Gastroenterol
Cao W, Cheng Y, Wang X, Wang L, Li R, Pei S, Zhang G, Petersen JD, Zhang P.   +8 more
europepmc   +1 more source

Adults With Acid Sphingomyelinase Deficiency Have Sustained Improvements in Clinical Outcomes With up to 5 Years of Olipudase Alfa Enzyme Replacement Therapy: ASCEND Trial Final Results. [PDF]

J Inherit Metab Dis
Wasserstein MP, Hollak CE, Barbato A, Gallagher RC, Giugliani R, Guelbert NB, Hennermann JB, Ikezoe T, Lachmann R, Lidove O, Mabe P, Mengel E, Scarpa M, Senates E, Tchan M, Thurberg BL, Villarrubia J, Armstrong NM, Bhushan S, Kim Y, Kumar M.   +20 more
europepmc   +1 more source

Comment on "SMPDL3B as a novel biomarker and therapeutic target in myalgic encephalomyelitis" critical considerations on biomarker validation and Supraphysiological drug concentrations. [PDF]

J Transl Med
Chen J, Yan L.
europepmc   +1 more source

SMPD1-mediated sphingolipid metabolism dysregulation in predicting and preventing in-stent restenosis of coronary heart disease patients. [PDF]

J Pharm Anal
Meng W, Sha Y, Zhong-Ga CR, Pan H, Zhai X, Zhen P, Tong HHY, Lao EPL, Zhang H, Yang W, Cui S, Song X, Li K.   +12 more
europepmc   +1 more source

Enhancing gemcitabine uptake by promoting dimerization of ENT1 transporter improves response rates of patients with sarcoma. [PDF]

J Clin Invest
Ganju A, Rao S, Dickson MA, Lefkowitz RA, Thompson C, Cheng J, Manova K, Haimovitz-Friedman A, Schwartz G, Zhang Z, Fuks Z, Tap WD, Kolesnick R.   +12 more
europepmc   +1 more source

Bacterial extracellular vesicles as recyclable nutrient reservoirs. [PDF]

Nat Commun
Laimer-Digruber A, Edelbacher TV, Alinaghi M, Yu MSC, Chiang DM, Kirchner B, Wudy SI, Tschulenk W, Walter I, Kummer S, Ludwig C, Přibyl J, Pfaffl MW, Ehling-Schulz M.   +13 more
europepmc   +1 more source

Metabolic improvement in patients with acid sphingomyelinase deficiency following intravenous trehalose administration: an untargeted pharmacometabolomic study. [PDF]

Orphanet J Rare Dis
Khoshakhlagh M, Hasanpour M, Iranshahi M, Asili J, Tasbandi A, Jamialahmadi T, Sahebkar A, Iranshahy M.   +7 more
europepmc   +1 more source

An update on schistosomicide and tumoricide in the future: arachidonic acid. [PDF]

Lipids Health Dis
Tallima H, El Ridi R.
europepmc   +1 more source

The toxic effects of α-hemolysin and β-hemolysin produced by <i>Staphylococcus aureus</i>. [PDF]

Front Immunol
Zhang Q, Wu Y, Luo D, Fang F.
europepmc   +1 more source

Early secretory pathway-resident Zn transporter proteins contribute to cellular sphingolipid metabolism through activation of sphingomyelin phosphodiesterase 1 [PDF]

American Journal of Physiology - Cell Physiology, 2022
Sphingomyelin phosphodiesterase 1 (SMPD1) converts sphingomyelin into ceramide and phosphocholine; hence, loss of SMPD1 function causes abnormal accumulation of sphingomyelin in lysosomes, which results in the lipid-storage disorder Niemann–Pick disease (types A and B).
Taiho Kambe, Tatsuya Sugawara, Yuki Manabe   +2 more
exaly   +5 more sources