Results 111 to 120 of about 13,482,017 (199)

Rolle der sauren Sphingomyelinase bei der Aktivierung von T-Lymphozyten

, 2018
Die Saure Sphingomyelinase und Ceramid modulieren diverse Aspekte der T-Zellaktivierung. T-Lymphozyten kommt bei der adaptiven Immunabwehr von Pathogenen eine zentrale Rolle zu.
Begum, Salina
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Lysosomal sphingomyelinase is not solicited for apoptosis signaling

, 2000
International audienceABSTRACT Stress‐induced activation of an acidic sphingomyelinase leading to generation of ceramide, an important lipid mediator, has been associated with apoptosis; however, the implication of this hydrolase has been questioned. The
Gouazé, Valérie, Stéphane Carpentier, Uro-Coste, Emmanuelle, Valérie Gouazé, Nathalie Andrieu‐Abadie, Guy Laurent, Jean‐Pierre Jaffrézou, Cuvillier, Olivier, Bezombes, Christine, Salvayre, Robert, Jaffrézou, Jean‐pierre, Emmanuelle Uro‐Coste, Thierry Levade, Bruno, Alain, Bruno Ségui, Robert Salvayre, Carpentier, Stéphane, Christine Bezombes, Olivier Cuvillier, Alain P. Bruno, Andrieu-Abadie, Nathalie, Levade, Thierry, Laurent, Guy, Ségui, Bruno   +23 more
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Regulation of Arthritis Severity by the Acid Sphingomyelinase

, 2017
Background/Aims: Rheumatoid arthritis is a chronic autoimmune disease hallmarked by inflammation in synovial joints. Treatment is hampered by the lack of a cure and current disease-modifying drugs are associated with potentially severe toxicities ...
Stefanie Weber, Joachim R. Göthert, Klaus Fassbender, Nadine Beckmann, Silke Walter, Jan U. Becker, Katrin Anne Becker, Alexander Carpinteiro, Melanie Kramer, Gabriele Hessler, Erich Gulbins   +10 more
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GM2 Gangliosidosis (Tay-Sachs Disease), type I, Infantile Form: Clinical Case

Вопросы современной педиатрии
Background. GM2 gangliosidosis (Tay-Sachs disease, variant B, type I) is an orphan disease with autosomal recessive inheritance. It develops due to gangliosides accumulation in tissues and organs. The description of clinical case of GM2 gangliosidosis in
Artem A. Babkin, Vladimir A. Shcherbak, Elena V. Leontieva, Lada A. Kirii   +3 more
doaj   +1 more source

Curcumin decreases acid sphingomyelinase activity in colon cancer caco-2 cells

, 2007
Curcumin has been shown to inhibit cell growth and induce apoptosis in colon cancer cells. The metabolism of sphingomyelin has implications in the development of colon cancer.
Duan, Rui-Dong, Duan, Rui-Dong,, Cheng, Yajun,, Sternby, Berit,, Kozubek, Agnieszka, Ohlsson, Lena,, Cheng, Yajun, Sternby, Berit, Lund University., Ohlsson, Lena   +9 more
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Acid sphingomyelinase serum activity in ICU patients with SIRS.

, 2014
Clear boxes represent survivors (n = 9) and grey boxes non-survivors (N = 10).
Supandi Winoto-Morbach (501243), Matthias Kott (657467), Gunnar Elke (449417), Inéz Frerichs (20627), Norbert Weiler (20632), Stefan Schütze (320441), Günther Zick (20626), Maike Reinicke (657468), Dirk Schädler (20628)   +8 more
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Gentamicin Targets Acid Sphingomyelinase in Cancer: The Case of the Human Gastric Cancer NCI-N87 Cells

, 2019
Emerging literature implicates acid sphingomyelinase in tumor sensitivity/resistance to anticancer treatments. Gentamicin is a drug commonly used as an antimicrobial but its serendipity effects have been shown.
Federica Filomena Patria, Maria Rachele Ceccarini, Elisabetta Albi, Samuela Cataldi, Ivana Ferri, Tommaso Beccari, Michela Codini, Carmela Conte, Katia Fettucciari   +8 more
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Preeclampsia risk, maternal 25-hydroxyvitamin D concentration, and variation in vitamin D metabolism pathway genes [PDF]

, 2016
OBJECTIVE: Our objectives were to study the relationships between 25-hydroxyvitamin D (25(OH)D) and preeclampsia risk, maternal genetic variation in 3 vitamin D metabolism genes (GC, CYP27B1, VDR) and preeclampsia risk, and variation in the same genes ...
Baca, Katharyn
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Differential Cellular Responses to Class I and II Sphingomyelinase D: Unraveling the Mechanisms of <i>Loxosceles</i> Venom-Induced Dermonecrosis and Potential Therapeutic Targets. [PDF]

Int J Mol Sci
Pinto BF, Lopes PH, Trufen CEM, Ching Ching AT, Junqueira de Azevedo ILM, Nishiyama-Jr MY, de Souza MM, Pohl PC, Tambourgi DV.   +8 more
europepmc   +1 more source

Document: Charles D. Drake

, 1898
Extract from speech of Charles D. Drake, chairman of Committee of Seventy, delivered at St.
Drake, Charles D.
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