Results 101 to 110 of about 13,482,017 (199)

Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth.

Journal of Lipid Research, 1995
Analogs and homologs of PDMP were synthesized, based on its structure (D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol). This compound had previously been found to block the synthesis of GlcCer (glucosylceramide).
A Abe, N S Radin, J A Shayman, L L Wotring, R E Zipkin, R Sivakumar, J M Ruggieri, K G Carson, B Ganem   +8 more
doaj   +1 more source

Ligand‑Based Virtual Screening Discovery of Thienopyrimidinone Derivatives as Allosteric nSMase2 Modulators and Antivirals Against West Nile Virus

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Ligand‐based virtual screening of over five million compounds identifies a thienopyrimidinone hit as a novel allosteric nSMase2 modulator. Structure‐guided optimisation improves inhibitory potency and delivers derivatives with antiviral activity against West Nile virus, expanding the chemical space of nSMase2 inhibitors and supporting host‐directed ...
Hadrián Álvarez‐Fernández, Patricia Mingo‐Casas, Ana‐Belén Blázquez, Flavia Caridi, Miguel A. Martín‐Acebes, María‐Jesús Pérez‐Pérez, Eva‐María Priego   +6 more
wiley   +1 more source

A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci [PDF]

, 2011
The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1.
Francis, S. E., Calogero Tulone, Read, R. C., Sheila E. Francis, Mitchell, T.J., Read Robert C., Benny Chain, Marriott, Helen M, Deretic, V., Dockrell, David H, Marriott, H.M., Francis, Sheila E, Dockrell, David H., Whyte, M.K.B., Martin A. Bewley, Mitchell Timothy J., Timothy J Mitchell, Whyte, Moira K B, Kroemer, G., Chain, B., Moira K. B. Whyte, Helen M Marriott, Sheila E Francis, Tulone Calogero, Robert C Read, Bewley, M.A., Dockrell, D.H., Whyte Moira K. B., Whyte, Moira K. B., Marriott Helen M., Read, Robert C., Marriott, H. M., Chain, Benny, Tulone, C., Read, R.C., Mitchell, Timothy J., Whyte, Moira K.B., David H. Dockrell, Mitchell, Timothy J, Francis Sheila E., David H Dockrell, Kroemer, Guido, Moira K B Whyte, Marriott, Helen M., Chain Benny, Mitchell, T. J., Timothy J. Mitchell, Bewley, Martin A, Dockrell, D. H., Read, Robert C, Tulone, Calogero, Francis, S.E., Robert C. Read, Dockrell David H., Bewley, Martin A., Martin A Bewley, Helen M. Marriott, Bewley, M. A., Dockrell, David, Bewley Martin A., Whyte, M. K. B., Guido Kroemer, Francis, Sheila E., Kroemer Guido   +63 more
core   +1 more source

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

Cellular Physiology and Biochemistry, 2013
Background/Aims: Several recent studies revealed an accumulation of ceramide in bronchial, tracheal and intestinal epithelial cells of mice and patients with cystic fibrosis (CF). Normalization of ceramide concentrations in lungs of CF mice employing the
Lutz Nährlich, Jochen G. Mainz, Constantin Adams, Corinna Engel, Gloria Herrmann, Vanya Icheva, Josefine Lauer, Caroline Deppisch, Andreas Wirth, Katy Unger, Ute Graepler-Mainka, Andreas Hector, Susanne Heyder, Martin Stern, Gerd Döring, Erich Gulbins, Joachim Riethmüller   +16 more
doaj   +1 more source

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis [PDF]

, 1996
Stress is believed to activate sphingomyelinase to generate ceramide, which serves as a second messenger in initiating the apoptotic response. Conclusive evidence for this paradigm, however, is lacking. In the present study, we used a genetic approach to
McLoughlin, Maureen, Schuchman, Edward H., Cordon-Cardo, Carlos, Peña, Louis A., Santana, Pino, Kolesnick, Richard, Haimovitz-Friedman, Adriana, Fuks, Zvi, Peña, Louis A, Martin, Seamus, Santana Delgado, María Del Pino, Green, Douglas, Schuchman, Edward H   +12 more
core   +1 more source

Effect of GM2 activator protein on the enzymatic hydrolysis of phospholipids and sphingomyelin

Journal of Lipid Research, 2003
GM2 activator protein (GM2AP) is a specific protein cofactor that stimulates the enzymatic hydrolysis of the GalNAc from GM2, a sialic acid containing glycosphingolipid, both in vitro and in lysosomes. While phospholipids together with glycosphingolipids
Yoshimi Shimada, Yu-Teh Li, Su-Chen Li
doaj   +1 more source

Staphylococcus aureus β-hemolysin impairs oxygen transport without causing hemolysis

Virulence
Staphylococcus aureus (S. aureus) infection can lead to the occurrence of hypoxia, however, the underlying mechanisms have not been fully elucidated. β-hemolysin (Hlb) induced hemolysis of red blood cells (RBCs) requires a temperature transition from ...
Qi Li, Nan Chen, Chenghua Liu, Zhen Zhao, Minjun Huang, Jingjing Li, Guang Yang   +6 more
doaj   +1 more source

Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress

Journal of Lipid Research, 2002
Ceramides (Cers), critical for epidermal barrier function, also can inhibit keratinocyte proliferation, while glucosylceramides (GlcCers) exert pro-mitogenic effects.
Yoshikazu Uchida, Satoru Murata, Matthias Schmuth, Martin J. Behne, Jeong Deuk Lee, Shinichi Ichikawa, Peter M. Elias, Yoshio Hirabayashi, Walter M. Holleran   +8 more
doaj   +1 more source

Kinetics of acid sphingomyelinase serum activity in the control group.

, 2014
The box plots display the minima/maxima (whiskers), 25%/75% percentile (box), median (−) and mean (+) values.
Supandi Winoto-Morbach (501243), Matthias Kott (657467), Gunnar Elke (449417), Inéz Frerichs (20627), Norbert Weiler (20632), Stefan Schütze (320441), Günther Zick (20626), Maike Reinicke (657468), Dirk Schädler (20628)   +8 more
core   +1 more source

Acid sphingomyelinase serum activity in control and ICU patients.

, 2014
This figure indicates median pre- and post-operative acid sphingomyelinase serum activity of the control group and median acid sphingomyelinase serum activity of the ICU group on admission.
Supandi Winoto-Morbach (501243), Matthias Kott (657467), Gunnar Elke (449417), Inéz Frerichs (20627), Norbert Weiler (20632), Stefan Schütze (320441), Günther Zick (20626), Maike Reinicke (657468), Dirk Schädler (20628)   +8 more
core   +1 more source