Results 91 to 100 of about 13,482,017 (199)

When EV Dose Is Not What It Seems: Quantitative Mismatch Between Particle Number‐ and Protein‐Based Dosing

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
Created with BioRender.com. ABSTRACT Extracellular vesicles (EVs) are widely studied as mediators of intercellular communication, yet their quantitative characterization remains inconsistent. In this study, we investigated how vesicle release rate, cellular proliferation, and tumour origin jointly shape EV‐associated protein output. Using a panel of 19
Tímea Böröczky, Mária Harmati, Edina Gyukity‐Sebestyén, Tamás F. Polgár, Csenge Feinek, Emma Balog, Antal Martinecz, Krisztina Buzás, Gabriella Dobra, Mátyás Bukva   +9 more
wiley   +1 more source

An Optimized Diagnostic Approach for Adults With Suspected Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
A multidisciplinary strategy that integrates deep phenotyping with expert genetic interpretation substantially increases the likelihood of reaching a diagnosis in adults suspected of having an IMD. ABSTRACT Inherited metabolic disorders (IMDs) arise from defects in metabolic pathways essential for normal biochemical function.
Machteld M. Oud, Elise A. Ferreira, Clara D. M. van Karnebeek, Robin Wijngaard, Nicole I. Wolf, Marc Engelen, Mareen Datema, Sacha Ferdinandusse, André B. P. van Kuilenburg, Laura Steinbusch, Saskia N. van der Crabben, Mirjam Langeveld, on behalf of the ZOEMBA Study Group   +12 more
wiley   +1 more source

Determination of sphingomyelinase-D activity of Loxosceles venoms in sphingomyelin/cholesterol liposomes containing horseradish peroxidase

Toxicon, 2011
Based on degradation of sphingomyelin/cholesterol liposomes containing entrapped horseradish peroxidase, we evaluated the Sphingomyelinase-D (SMase-D) activity of scorpion, spider and snake venoms by monitoring spectrophotometrically the product of oxidation of HRP released.
Gomes, Marco Túlio R., Guimarães, Gabriela, Frézard, Frédéric, Kalapothakis, Evanguedes, Minozzo, João Carlos, Chaim, Olga Meiri, Veiga, Silvio Sanches, Oliveira, Sergio Costa, Chávez-Olórtegui, Carlos   +8 more
openaire   +2 more sources

Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase

Molecular Cancer, 2010
Background Ceramide is an important second messenger that has diverse cellular and biological effect. It is a specific and potent inducer of apoptosis and suppressor of cell growth.
Mondal Susmita, Mandal Chandan, Sangwan Rajender, Chandra Sarmila, Mandal Chitra   +4 more
doaj   +1 more source

Molecular Mechanisms and Therapeutic Applications of Extracellular Vesicles in Remodeling of the Skin Cancer Niche

Nano Select, Volume 7, Issue 9, September 2026.
Extracellular vesicles at the nexus of skin cancer progression and precision therapy. EVs orchestrate tumor microenvironment remodeling through cargo‐mediated intercellular communication, immune modulation, angiogenesis, and extracellular matrix reorganization, while also emerging as next‐generation platforms for targeted drug delivery, biomarker ...
Megha Kotian, Maria Nison, Deepanjan Datta, Soniya Kumbham, Namdev Dhas, Praveen Halagali, Vasudev R Pai, Vamshi Krishna Tippavajhala   +7 more
wiley   +1 more source

Urotensin II Receptor Deletion Mitigates Kidney Injury and Renal Lipid Remodeling in Mice Fed a Long‐Term High‐Fat Diet

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
Urotensin II receptor deletion mitigates high‐fat diet‐induced kidney injury and renal lipid remodeling. Male wild‐type (WT) and urotensin II receptor–knockout (UT KO) mice were fed a high‐fat diet (HFD; 60% kcal from fat) for 33 weeks. In cultured mouse podocytes, urotensin II (UII)–UT signaling enhanced transient receptor potential canonical 6 (TRPC6)
Praghalathan Kanthakumar, Adebowale Adebiyi   +1 more
wiley   +1 more source

Activation of phospholipase D-2 by P2X7 agonists in rat submandibular gland acini

Journal of Lipid Research, 2002
Exogenous ATP stimulated phospholipase D (PLD), but not sphingomyelinase in rat submandibular gland (SMG) acini. PLD activation was dependent upon extracellular Ca2+ and did not involve intracellular Ca2+ mobilization or phosphoinositide-specific ...
Encarnación Pérez-Andrés, María Fernández-Rodriguez, Mónica González, Ana Zubiaga, Ainara Vallejo, Itxaso García, Carlos Matute, Stéphanie Pochet, Jean Paul Dehaye, Miguel Trueba, Aida Marino, Antonio Gómez-Muñoz   +11 more
doaj   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, Volume 59, Issue 9, September 2026.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Detection of alkaline sphingomyelinase activity in human stool: proposed role as a new diagnostic and prognostic marker of colorectal cancer

, 2005
OBJECTIVES: Intestinal alkaline sphingomyelinase, by exerting a major role in dietary sphingomyelin digestion, is responsible for the generation of messengers able to trigger the rapid turnover and apoptosis in intestinal epithelial cells.
Barone M, CINQUE, BENEDETTA, AGNIFILI, Alessio, LORUSSO, DANIELA, Linsalata M, De Simone C, Berloco P, Di Leo A, Fanini D, Di Marzio L, CIFONE, MARIA GRAZIA   +10 more
core   +1 more source

Apoptosis and signalling in acid sphingomyelinase deficient cells [PDF]

, 2000
Background Recent evidence suggests that the activation of a non-specific lipid scramblase during apoptosis induces the flipping of sphingomyelin from the cell surface to the cytoplasmic leaftet of the plasma membrane. Inner leaflet sphingomyelin is then
Sillence Dan J, Dan J Sillence, Sillence, Daniel J.   +2 more
core   +1 more source