Results 81 to 90 of about 13,482,017 (199)

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Tetracycline reprograms inflammatory and regenerative signaling pathways in human keratinocytes exposed to Loxosceles spider venoms and sphingomyelinases

Frontiers in Pharmacology
IntroductionLoxosceles spider envenomation, or loxoscelism, constitutes the most severe form of araneism and frequently progresses to dermonecrosis with significant tissue damage.
Bruna Fernandes Pinto, Priscila Hess Lopes, Carlos Eduardo Madureira Trufen, Ana Tung Ching Ching, Inácio de Loiola Meirelles Junqueira de Azevedo, Milton Yutaka Nishiyama-Jr, Denise V. Tambourgi   +6 more
doaj   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

Hyperresponsiveness of mice defi cient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response [PDF]

, 2013
Plasma secretion of acid sphingomyelinase is a hallmark of cellular stress response resulting in the formation of membrane embedded ceramide-enriched lipid rafts and the reorganization of receptor complexes.
Acht, Benedikt, Bockmeyer, Clemens L., Deigner, H. P., Suckert, Iris, Jbeily, N., Claus, R. A., Bläss, Markus, Acht, B., Gonnert, Falk A., Grossmann, S. D., Lüth, Anja, Claus, Ralf A., Jbeily, Nayla, Blaess, Markus F., Grossmann, Sascha D., Suckert, I., Gonnert, F. A., Bockmeyer, C. L., Blaess, M. F., Deigner, Hans-Peter, Bauer, Michael, Bauer, M., Lüth, A.   +22 more
core   +1 more source

Association Between the Root Canal Microbiome and Apical Lesion Size: An Observational Shotgun Metagenomic Study

International Endodontic Journal, Volume 59, Issue 10, Page 2211-2222, October 2026.
ABSTRACT Aim The aim was to characterize the taxonomic and functional composition of the microbiome involved in primary endodontic infections and to evaluate their association with the periapical lesion size using shotgun metagenomic sequencing. Methodology Samples from primary root canal infections diagnosed with apical periodontitis were analysed ...
Virginia Pérez‐Carrasco, David Uroz‐Torres, Ana Soriano‐Lerma, Miguel Soriano, Jose Antonio García‐Salcedo, Maria Teresa Arias‐Moliz   +5 more
wiley   +1 more source

Pharmacological Inhibition of Small Extracellular Vesicle Secretion by ALK5i SD‐208 via Lysosomal Rerouting of CD63+ Compartments

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
ABSTRACT Pharmacological tools to selectively modulate extracellular vesicle (EV) secretion are scarce. Here, we identify the ALK5 (TGF‐β receptor I) inhibitor SD‐208 as a potent suppressor of small EV (sEV) secretion that acts independently of its canonical anti‐fibrotic activity.
Rahul Sanwlani, Georgina H. Thompson, Kyle Bramich, Ching‐Seng Ang, Millie L. Trowbridge, Chris E. Duringer, Vlad Stolojan, Sean M. Davidson, Konstantinos Savvatis, John H. McVey, Suresh Mathivanan, Aled Clayton, Patrizia Camelliti   +12 more
wiley   +1 more source

Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls

, 2016
Simon R Lea,1,* Hannah J Metcalfe,1,* Jonathan Plumb,1 Christian Beerli,2 Chris Poll,3 Dave Singh,1 Katharine H Abbott-Banner3 1Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre,
Poll C, Beerli C, Abbott-Banner KH, Plumb J, Lea SR, Metcalfe HJ, Singh D   +6 more
core  

Identifikation neuer klinischer Anwendungen für Saure Sphingomyelinase Inhibitoren [PDF]

, 2017
Acid sphingomyelinase is a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide. Acid sphingomyelinase/ceramide have been implicated in the pathogenesis of a number of different diseases.
Beckmann, Nadine
core  

N,N-Dimethyl-D-erythro-Sphingosine Inhibits Store-Operated Ca2+ Entry in U937 Monocytes

Journal of Pharmacological Sciences, 2008
Calcium is a ubiquitous second messenger that controls a broad range of cellular functions, and store-operated calcium entry (SOCE) is the primary mechanism of regulated Ca2+ entry in non-excitable immunocytes. In this study, we found that N,N-dimethyl-D-
Ji-Yeong Jo, Hyo-Lim Kim, Yun-Kyung Lee, Hideaki Tomura, Yoe-Sik Bae, Fumikazu Okajima, Dong-Soon Im   +6 more
doaj   +1 more source

Vitamin D levels and tumor necrosis factor-α activity in newly diagnosed patients with type 2 diabetes mellitus: An exploratory study in North-East India

Asian Journal of Medical Sciences
Background: Diabetes poses a global threat, leading to hospitalizations and premature death if not managed properly. It involves tumor necrosis factor-α (TNF-α), an inflammatory cytokine, which binds to TNF-α receptor-1, triggering sphingomyelinase, and ...
Rahul Dubey , Anju Barhoi Teli , Uttam Kumar Nath , Bharati Devi , Anuradha Hazarika Medhi , Dharma Rao Vanamali   +5 more
doaj   +1 more source