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Sphingomyelinase D in sicariid spider venom is a potent insecticidal toxin
Toxicon, 2012Spider venoms have evolved over hundreds of millions of years with a primary role of immobilizing prey. Sphingomyelinase D (SMase D) and homologs in the SicTox gene family are the most abundantly expressed toxic protein in venoms of Loxosceles and Sicarius spiders (Sicariidae).
Pamela A, Zobel-Thropp +2 more
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Bacterial and Arachnid Sphingomyelinases D: Comparison of Biophysical and Pathological Activities.
Journal of cellular biochemistry, 2017Sphingomyelinases D have only been identified in arachnid venoms, Corynebacteria, Arcanobacterium, Photobacterium and in the fungi Aspergillus and Coccidioides. The arachnid and bacterial enzymes share very low sequence identity and do not contain the HKD sequence motif characteristic of the phospholipase D superfamily, however, molecular modeling and ...
Mariutti, Ricardo Barros +8 more
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Acid sphingomyelinase possesses a domain homologous to its activator proteins: Saposins B and D [PDF]
Protein Science, 1994 AbstractAn N‐terminal region of the acid sphingomyelinase sequence (residues 89‐165) is shown to be homologous to saposintype sequences. By analogy with the known functions of saposins, this sphingomyelinase saposin‐type domain may possess lipid‐binding and/or sphingomyelinase‐activator properties.
Chris Ponting
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Niemann‐pick disease type D: Lipid analyses and studies on sphingomyelinases
Annals of Neurology, 1977AbstractLipids and sphingomyelinase activity were studied in spleen, liver, and brain tissues of a 13‐year‐old boy with Niemann‐Pick disease type D (NPD‐D). The greatest lipid changes occurred in spleen; cholesterol, cholesterol esters, total phospholipids, sphingomyelin, and bis‐(monoacylglyceryl)phosphate were increased above normal range.
B G, Rao, M W, Spence
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Archives of Toxicology, 2020
The spiders of the Loxosceles genus (called brown or violin spiders) are of medical relevance in several countries due to the many human envenomation cases reported. The main component of Loxosceles venom is the enzyme sphingomyelinase D (SMase D), which is responsible for the local and systemic effects induced by the whole venom. Here, we investigated
Marcelo Santos da Silva +3 more
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The spiders of the Loxosceles genus (called brown or violin spiders) are of medical relevance in several countries due to the many human envenomation cases reported. The main component of Loxosceles venom is the enzyme sphingomyelinase D (SMase D), which is responsible for the local and systemic effects induced by the whole venom. Here, we investigated
Marcelo Santos da Silva +3 more
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Biochemical and Biophysical Research Communications, 2006
Spider venom sphingomyelinases D catalyze the hydrolysis of sphingomyelin via an Mg(2+) ion-dependent acid-base catalytic mechanism which involves two histidines. In the crystal structure of the sulfate free enzyme determined at 1.85A resolution, the metal ion is tetrahedrally coordinated instead of the trigonal-bipyramidal coordination observed in the
Murakami, M. T. +6 more
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Spider venom sphingomyelinases D catalyze the hydrolysis of sphingomyelin via an Mg(2+) ion-dependent acid-base catalytic mechanism which involves two histidines. In the crystal structure of the sulfate free enzyme determined at 1.85A resolution, the metal ion is tetrahedrally coordinated instead of the trigonal-bipyramidal coordination observed in the
Murakami, M. T. +6 more
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Toxicon, 2006
Envenomation by arachnids of the genus Loxosceles leads to local dermonecrosis and serious systemic toxicity mainly induced by sphingomyelinases D (SMase D). These enzymes catalyze the hydrolysis of sphingomyelin resulting in the formation of ceramide-phosphate and choline as well as the cleavage of lysophosphatidyl choline generating the lipid ...
de Andrade, S. A. +4 more
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Envenomation by arachnids of the genus Loxosceles leads to local dermonecrosis and serious systemic toxicity mainly induced by sphingomyelinases D (SMase D). These enzymes catalyze the hydrolysis of sphingomyelin resulting in the formation of ceramide-phosphate and choline as well as the cleavage of lysophosphatidyl choline generating the lipid ...
de Andrade, S. A. +4 more
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Archives of Toxicology, 2023
Sphingomyelinase D (SMase D), the main toxic component of Loxosceles venom, has a well-documented role on dermonecrotic lesion triggered by envenomation with these species; however, the intracellular mechanisms involved in this event are still poorly known. Through differential transcriptomics of human keratinocytes treated with L.
Bruna Fernandes Pinto +7 more
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Sphingomyelinase D (SMase D), the main toxic component of Loxosceles venom, has a well-documented role on dermonecrotic lesion triggered by envenomation with these species; however, the intracellular mechanisms involved in this event are still poorly known. Through differential transcriptomics of human keratinocytes treated with L.
Bruna Fernandes Pinto +7 more
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Journal of Experimental Therapeutics and Oncology, 2002
Hexadecylphosphocholine (HePC) is the first representative of the alkylphosphocholines (APC), a new group of biologically active compounds. HePC has pronounced antiproliferative effects on neoplastic cells in vitro and in vivo. The molecular mechanism by which HePC exerts its biological effects is still under investigation.
Dinko, Berkovic +4 more
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Hexadecylphosphocholine (HePC) is the first representative of the alkylphosphocholines (APC), a new group of biologically active compounds. HePC has pronounced antiproliferative effects on neoplastic cells in vitro and in vivo. The molecular mechanism by which HePC exerts its biological effects is still under investigation.
Dinko, Berkovic +4 more
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Archives Italiennes de Biologie, 2020
Contextual fear conditioning (CFC) paradigm is routinely used to study fear-based learning in animals and it provides a useful model for understanding fear and anxiety in human. In the present study, such model was used following the previously established CFC protocol, and immunohistochemistry, enzymatic activity and western blotting analysis ...
ELISABETTA ALBI +9 more
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Contextual fear conditioning (CFC) paradigm is routinely used to study fear-based learning in animals and it provides a useful model for understanding fear and anxiety in human. In the present study, such model was used following the previously established CFC protocol, and immunohistochemistry, enzymatic activity and western blotting analysis ...
ELISABETTA ALBI +9 more
openaire +3 more sources