Results 1 to 10 of about 8,712 (201)

Lipid balance and chemoresistance in cancer cells [PDF]

eLife
A shift in the balance between two lipids – cholesterol and sphingomyelin – makes hybrid epithelial-mesenchymal cancer cells less responsive to certain chemotherapy drugs.
Kaori Kanemaru, Yoshikazu Nakamura
doaj   +2 more sources

Lipid Subclasses Differentiate Insulin Resistance by Triglyceride–Glucose Index [PDF]

Metabolites
Background: Insulin resistance is a key driver of metabolic syndrome and related disorders, yet its underlying metabolic alterations remain incompletely understood.
Khaled Naja, Najeha Anwardeen, Omar Albagha, Mohamed A. Elrayess   +3 more
doaj   +2 more sources

Selective association of plasma sphingolipid species with insulin sensitivity and secretion in normoglycemic Black and White American adults [PDF]

Experimental Biology and Medicine
Ceramides and other sphingolipids are associated with diabetes risk. Here, we examined the association of plasma sphingolipids with insulin sensitivity and secretion in people without diabetes.
Peace Asuzu, Naser Aliye Feto, Jim Wan, Frankie Stentz, Nawajes Mandal, Samuel Dagogo-Jack   +5 more
doaj   +2 more sources

Composition of human serum sphingomyelins

Journal of Lipid Research, 1970
Serum sphingomyelins were analyzed by argentation chromatography of the corresponding ceramide diacetates. Six subfractions were obtained. Three of them contained 4-sphingenines in combination with saturated, trans-, or cis-monoenoic fatty acids; the ...
E.L. Hirvisalo, O. Renkonen
doaj   +3 more sources

Nonalcoholic fatty liver disease stratification by liver lipidomics

Journal of Lipid Research, 2021
Nonalcoholic fatty liver disease (NAFLD) is a common metabolic dysfunction leading to hepatic steatosis. However, NAFLD's global impact on the liver lipidome is poorly understood.
Olga Vvedenskaya, Tim Daniel Rose, Oskar Knittelfelder, Alessandra Palladini, Judith Andrea Heidrun Wodke, Kai Schuhmann, Jacobo Miranda Ackerman, Yuting Wang, Canan Has, Mario Brosch, Veera Raghavan Thangapandi, Stephan Buch, Thomas Züllig, Jürgen Hartler, Harald C. Köfeler, Christoph Röcken, Ünal Coskun, Edda Klipp, Witigo von Schoenfels, Justus Gross, Clemens Schafmayer, Jochen Hampe, Josch Konstantin Pauling, Andrej Shevchenko   +23 more
doaj   +1 more source

Sphingomyelins Prevent Propagation of Lipid Peroxidation—LC-MS/MS Evaluation of Inhibition Mechanisms

Molecules, 2020
Free radical driven lipid peroxidation is a chain reaction which can lead to oxidative degradation of biological membranes. Propagation vs. termination rates of peroxidation in biological membranes are determined by a variety of factors including fatty ...
Giulia Coliva, Mike Lange, Simone Colombo, Jean-Pierre Chervet, M. Rosario Domingues, Maria Fedorova   +5 more
doaj   +1 more source

Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes

Journal of Lipid Research, 2021
Recent studies suggest that the type of saturated fatty acid bound to sphingolipids influences the biological activity of those sphingolipids. However, it is unknown whether associations of sphingolipids with diabetes may differ by the identity of bound ...
Amanda M. Fretts, Paul N. Jensen, Andrew N. Hoofnagle, Barbara McKnight, Barbara V. Howard, Jason Umans, Colleen M. Sitlani, David S. Siscovick, Irena B. King, Luc Djousse, Nona Sotoodehnia, Rozenn N. Lemaitre   +11 more
doaj   +1 more source

Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations

Cancer Medicine, 2020
Large granular lymphocyte (LGL) leukemia is a rare hematological disorder with expansion of the T‐cell or natural killer (NK) cell lineage. Signal transducer and activator of transcription 3 (STAT3) exhibits somatic activating mutations in 30%‐40% of LGL
Kristine C. Olson, Katharine B. Moosic, Marieke K. Jones, Paige M. K. Larkin, Thomas L. Olson, Mariella F. Toro, Todd E. Fox, David J. Feith, Thomas P. Loughran Jr   +8 more
doaj   +1 more source

Different Lipid Signature in Fibroblasts of Long-Chain Fatty Acid Oxidation Disorders

Cells, 2021
Long-chain fatty acid oxidation disorders (lc-FAOD) are a group of diseases affecting the degradation of long-chain fatty acids. In order to investigate the disease specific alterations of the cellular lipidome, we performed undirected lipidomics in ...
Khaled I. Alatibi, Judith Hagenbuchner, Zeinab Wehbe, Daniela Karall, Michael J. Ausserlechner, Jerry Vockley, Ute Spiekerkoetter, Sarah C. Grünert, Sara Tucci   +8 more
doaj   +1 more source

Sphingomyelins and ceramides with VLCPUFAs are excluded from low-density raft-like domains in differentiating spermatogenic cells

Journal of Lipid Research, 2017
Rat spermatogenic cells contain sphingomyelins (SMs) and ceramides (Cers) with very long-chain PUFAs (VLCPUFAs) in nonhydroxylated (n-V) and 2-hydroxylated (h-V) forms. How these atypical species distribute among membrane fractions during differentiation
Florencia X. Santiago Valtierra, Melina V. Mateos, Marta I. Aveldaño, Gerardo M. Oresti   +3 more
doaj   +1 more source