Increasing PFAS concentrations in human serum correlate with elevated blood lipid levels.
Falls AT +9 more
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Comparative analysis of targeted metabolomic profiles reveals plasma metabolite differences across three Italian heavy pig breeds. [PDF]
Bovo S +10 more
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Prenatal Organophosphate Pesticide Exposure and Targeted Maternal Pregnancy Metabolomic Profiles in the NYU CHES Cohort. [PDF]
Cavalier H +11 more
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Corynebacterium pseudotuberculosis phospholipase D targets mitochondrial sphingomyelin and induces NLRP3-GSDMD axis-mediated pyroptosis in macrophages to promote infection. [PDF]
Li X +12 more
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Small Extracellular Vesicles with a High Sphingomyelin Content Isolated from Hypertensive Diabetic db/db Mice Inhibits Calcium Mobilization and Augments Amiloride-Sensitive Epithelial Sodium Channel Activity. [PDF]
Ramsay H, Yu L, Alousi FF, Alli AA.
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Sphingomyelin metabolites inhibit sphingomyelin synthase and CTP:phosphocholine cytidylyltransferase
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2001Tissue injury in inflammation involves the release of several cytokines that activate sphingomyelinases and generate ceramide. In the lung, the impaired metabolism of surfactant phosphatidylcholine (PC) accompanies this acute and chronic injury. These effects are long-lived and extend beyond the time frame over which tumor necrosis factor (TNF)-α and ...
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Interbilayer interactions between sphingomyelin and sphingomyelin/cholesterol bilayers
Biochemistry, 1992Pressure versus fluid spacing relations have been obtained for sphingomyelin bilayers in the gel phase and equimolar sphingomyelin/cholesterol in the liquid-crystalline phase by the use of X-ray diffraction analysis of osmotically stressed aqueous dispersions and oriented multilayers.
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Inhibitors of the sphingomyelin cycle: Sphingomyelin synthases and sphingomyelinases
Chemistry and Physics of Lipids, 2016Sphingolipids are a class of bioactive lipids, which are key modulators of an increasing number of physiologic and pathophysiologic processes that include cell cycle, apoptosis, angiogenesis, stress and inflammatory responses. Sphingomyelin is an important structural component of biological membranes, and one of the end-points in the synthesis of ...
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