Results 21 to 30 of about 8,712 (201)

Multi-omics driven predictions of response to acute phase combination antidepressant therapy: a machine learning approach with cross-trial replication

Translational Psychiatry, 2021
Combination antidepressant pharmacotherapies are frequently used to treat major depressive disorder (MDD). However, there is no evidence that machine learning approaches combining multi-omics measures (e.g., genomics and plasma metabolomics) can achieve ...
Jeremiah B. Joyce, Caroline W. Grant, Duan Liu, Siamak MahmoudianDehkordi, Rima Kaddurah-Daouk, Michelle Skime, Joanna Biernacka, Mark A. Frye, Taryn Mayes, Thomas Carmody, Paul E. Croarkin, Liewei Wang, Richard Weinshilboum, William V. Bobo, Madhukar H. Trivedi, Arjun P. Athreya   +15 more
doaj   +1 more source

Presence of unsaturated sphingomyelins and changes in their composition during the life cycle of the moth Manduca sexta

Journal of Lipid Research, 2004
NMR and electrospray ionization tandem mass spectrometry were used to show for the first time the presence of sphingomyelins in extracts of the tobacco hornworm Manduca sexta (Lepidoptera).
D.T.U. Abeytunga, James J. Glick, Nicholas J. Gibson, Lynne A. Oland, Arpad Somogyi, Vicki H. Wysocki, Robin Polt   +6 more
doaj   +1 more source

Effects of Pregnancy on Plasma Sphingolipids Using a Metabolomic and Quantitative Analysis Approach

Metabolites, 2023
Changes in the maternal metabolome, and specifically the maternal lipidome, that occur during pregnancy are relatively unknown. The objective of this investigation was to evaluate the effects of pregnancy on sphingolipid levels using metabolomics ...
Luke F. Enthoven, Yuanyuan Shi, Emily Fay, Agnes Kim, Sue Moreni, Jennie Mao, Nina Isoherranen, Rheem A. Totah, Mary F. Hebert   +8 more
doaj   +1 more source

Liquid chromatography-mass spectrometry-based metabolomic profiling reveals sex differences of lipid metabolism among the elderly from Southwest China

BMC Geriatrics, 2023
Background The sexual dimorphism represents one of the triggers of the metabolic disparities while the identification of sex-specific metabolites in the elderly has not been achieved.
Yuan-Jun Huang, Wei Ke, Ling Hu, You-Dong Wei, Mei-Xue Dong   +4 more
doaj   +1 more source

Raft-based sphingomyelin interactions revealed by new fluorescent sphingomyelin analogs [PDF]

Journal of Cell Biology, 2017
Sphingomyelin (SM) has been proposed to form cholesterol-dependent raft domains and sphingolipid domains in the plasma membrane (PM). How SM contributes to the formation and function of these domains remains unknown, primarily because of the scarcity of suitable fluorescent SM analogs.
Masanao Kinoshita, Kenichi G.N. Suzuki, Nobuaki Matsumori, Misa Takada, Hikaru Ano, Kenichi Morigaki, Mitsuhiro Abe, Asami Makino, Toshihide Kobayashi, Koichiro M. Hirosawa, Takahiro K. Fujiwara, Akihiro Kusumi, Michio Murata   +12 more
openaire   +2 more sources

Fatty acid composition of human brain sphingomyelins: normal variation with age and changes during myelin disorders

Journal of Lipid Research, 1965
Sphingomyelins have been isolated in almost quantitative yield from normal and pathological human nervous tissues, and their fatty acid compositions determined by gas–liquid chromatography.
Stina Ställberg-Stenhagen, Lars Svennerholm   +1 more
doaj   +1 more source

The Multigenic Sphingomyelin Synthase Family [PDF]

Journal of Biological Chemistry, 2006
Sphingomyelin (SM)3 is a vital component of cellular membranes in organisms ranging from mammals to protozoa. Its production involves the enzymatic transfer of a phosphocholine head group fromphosphatidylcholine to ceramide, yielding diacylglycerol in the process.
Geta Tafesse, F., Ternes, P.G., Holthuis, J.C.M.   +2 more
openaire   +4 more sources

Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation[S]

Journal of Lipid Research, 2009
Molecular events involved in successful embryo implantation are not well understood. In this study, we used MALDI imaging mass spectrometry (IMS) technologies to characterize the spatial and temporal distribution of phospholipid species associated with ...
Kristin E. Burnum, Dale S. Cornett, Satu M. Puolitaival, Stephen B. Milne, David S. Myers, Susanne Tranguch, H. Alex Brown, Sudhansu K. Dey, Richard M. Caprioli   +8 more
doaj   +1 more source

Altered Sphingolipids, Glycerophospholipids, and Lysophospholipids Reflect Disease Status in Idiopathic Steroid-Sensitive Nephrotic Syndrome in Children: A Non-Targeted Metabolomic Study

Cells
Idiopathic steroid-sensitive nephrotic syndrome (ISSNS) is the most common glomerular disease in children, yet its molecular mechanisms and lipid-mediated pathophysiology remain poorly understood.
Takahiro Kanai, Hideo Ogiso, Jun Aoyagi, Masanori Kurosaki, Tomomi Maru, Marika Ishii, Kazuya Tanimoto, Mitsuaki Yoshino, Yuri Yamashita, Toshihiro Tajima, Ryozo Nagai, Kenichi Aizawa   +11 more
doaj   +1 more source

Plasma Ceramides and Sphingomyelins in Relation to Atrial Fibrillation Risk: The Cardiovascular Health Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Ceramides exhibit multiple biological activities that may influence the pathophysiological characteristics of atrial fibrillation (AF). Whether the length of the saturated fatty acid carried by the ceramide or their sphingomyelin precursors ...
Paul N. Jensen, Amanda M. Fretts, Andrew N. Hoofnagle, Colleen M. Sitlani, Barbara McKnight, Irena B. King, David S. Siscovick, Bruce M. Psaty, Susan R. Heckbert, Dariush Mozaffarian, Nona Sotoodehnia, Rozenn N. Lemaitre   +11 more
doaj   +1 more source