Results 41 to 50 of about 8,712 (201)

Exploring Metabolic and Gut Microbiome Responses to Paraquat Administration in Male Wistar Rats: Implications for Oxidative Stress

Antioxidants
In this study, we examined the metabolic and gut microbiome responses to paraquat (PQ) in male Wistar rats, focusing on oxidative stress effects. Rats received a single intraperitoneal injection of PQ at 15 and 30 mg/kg, and various oxidative stress ...
Julia Hernandez-Baixauli, Gertruda Chomiciute, Harry Tracey, Ignasi Mora, Antonio J. Cortés-Espinar, Javier Ávila-Román, Nerea Abasolo, Hector Palacios-Jordan, Elisabet Foguet-Romero, David Suñol, Mar Galofré, Juan María Alcaide-Hidalgo, Laura Baselga-Escudero, Josep M. del Bas, Miquel Mulero   +14 more
doaj   +1 more source

Roux-en-Y Gastric Bypass Surgery Induces Distinct but Frequently Transient Effects on Acylcarnitine, Bile Acid and Phospholipid Levels

Metabolites, 2018
Roux-en-Y gastric bypass (RYGB) is an effective method to achieve sustained weight loss, but the mechanisms responsible for RYGB effects have not yet been fully characterized.
Jarlei Fiamoncini, Carina Fernandes Barbosa, José Rubens Arnoni Junior, José Celestino Araújo Junior, Cinthia Taglieri, Tiago Szego, Barbara Gelhaus, Heraldo Possolo de Souza, Hannelore Daniel, Thais Martins de Lima   +9 more
doaj   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Circulating ceramides and sphingomyelins and the risk of incident cardiovascular disease among people with diabetes: the strong heart study

Cardiovascular Diabetology, 2022
Background Plasma ceramides and sphingomyelins have been independently linked to diabetes risk, glucose and insulin levels, and the risk of several cardiovascular (CVD) outcomes.
Paul N. Jensen, Amanda M. Fretts, Andrew N. Hoofnagle, Barbara McKnight, Barbara V. Howard, Jason G. Umans, Colleen M. Sitlani, David S. Siscovick, Irena B. King, Nona Sotoodehnia, Rozenn N. Lemaitre   +10 more
doaj   +1 more source

Cohort‐Scale Spatial Autocorrelation for Tumor Prediction in Mid‐Infrared Pathology and Spatial Biomarker Discovery Using MALDI Imaging Lipidomics

Advanced Science, EarlyView.
Computational annotation of various tissue types in heterogeneous samples such as colorectal cancer liver metastasis (CRLM) using spatial autocorrelation analysis on non‐destructive mid‐infrared (MIR) imaging data enabled correlative multimodal mass spectrometry imaging (MSI) for spatial investigation of lipid tumor marker candidates. The method can be
Miriam F. Rittel, Nikolas Ebert, Denis Abu Sammour, Sebastian Graf, Björn C. Fröhlich, Emrullah Birgin, Shad A. Mohammed, Nuh N. Rahbari, Axel Wellmann, Oliver Wasenmüller, Cleo‐Aron Weis, Stefan Schmidt, Carsten Hopf   +12 more
wiley   +1 more source

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source

Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity

AGING MEDICINE, EarlyView.
Investigating centenarians who exemplify healthy longevity can aid in formulating preventive strategies aimed at achieving health and extending lifespan in the context of population aging. Hainan longevity model (HLM) plays key roles in promoting healthy longevity and provides scientific evidence for achieving healthy longevity in the older population.
Shihui Fu, Jiacai Lin, Qianshuo Liu, Lianbo Gao, Zhirui Li, Feng Lin, Leixing Xie, Xiong Liu, Wenkai Xiao, Qiwei Zhu, Fan Wang, Jin Zheng, Yali Zhao, Xiaolei Chen, Yao Yao, Long Feng   +15 more
wiley   +1 more source

Partial synthesis and properties of a series of N-acyl sphingomyelins.

Journal of Lipid Research, 1987
A series of sphingomyelins (SM) with different chain length fatty acids (C14:0, C16:0, C18:0, C20:0, C22:0, and C24:0) N-linked to the primary amino group of sphingosine have been synthesized starting with bovine brain SM.
P K Sripada, P R Maulik, J A Hamilton, G G Shipley   +3 more
doaj   +1 more source

Associations among circulating sphingolipids, β-cell function, and risk of developing type 2 diabetes: A population-based cohort study in China.

PLoS Medicine, 2020
BackgroundAnimal studies suggest vital roles of sphingolipids, especially ceramides, in the pathogenesis of type 2 diabetes (T2D) via pathways involved in insulin resistance, β-cell dysfunction, and inflammation, but human studies are limited.
Huan Yun, Liang Sun, Qingqing Wu, Geng Zong, Qibin Qi, Huaixing Li, He Zheng, Rong Zeng, Liming Liang, Xu Lin   +9 more
doaj   +1 more source

High-Density Lipoprotein Lipidomics and Mortality in CKD

Kidney Medicine, 2023
Rationale & Objective: Patients with chronic kidney disease (CKD) have dysfunctional high-density lipoprotein (HDL) particles that lack cardioprotective properties; altered lipid composition may be associated with these changes.
Benjamin Lidgard, Andrew N. Hoofnagle, Leila R. Zelnick, Ian H. de Boer, Amanda M. Fretts, Bryan R. Kestenbaum, Rozenn N. Lemaitre, Cassianne Robinson-Cohen, Nisha Bansal   +8 more
doaj   +1 more source