Results 101 to 110 of about 102,609 (313)
Sphingosine‐1‐phosphate receptors and innate immunity
Cellular Microbiology, 2018 Sphingosine‐1‐phosphate (S1P) is a signalling lipid that regulates many cellular processes in mammals. One well‐studied role of S1P signalling is to modulate T‐cell trafficking, which has a major impact on adaptive immunity.
Arielle M. Bryan, M. Del Poeta
semanticscholar +1 more source
Sphingosine 1-phosphate signalling [PDF]
Development, 2014 Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival.
Karen, Mendelson +2 more
openaire +2 more sources
Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis
British Journal of Clinical Pharmacology, EarlyView.Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley +1 more source
Frontiers in Molecular BiosciencesIntroduction: Hexavalent chromium [Cr (VI)] has been identified as a human carcinogen and environmental pollutant capable of affecting multiple systems in the human body.
Hongge Tang +4 more
doaj +1 more source
New methods for determining the enantiomeric purity of erythro-sphingosine
Journal of Lipid Research, 1999 The enantiomeric purity of erythro-sphingosine samples can be determined simply, reliably, and accurately from 1H or 19F nuclear magnetic resonance spectra of the α-methoxy-α-(trifluoromethyl)phenylacetate (MTPA) derivative.
Shengrong Li +2 more
doaj +1 more source
Lamellar and inverse micellar structures of skin lipids: Effect of templating [PDF]
, 2014 The outermost layer of skin, the stratum corneum (SC), comprises rigid corneocytes in a layered lipid matrix. Using atomistic simulations we find that the equilibrium phase of the SC lipids is inverse micellar.
Das, Chinmay +2 more
core +1 more source
Sphingosine Kinases/Sphingosine 1-Phosphate Signaling in Hepatic Lipid Metabolism [PDF]
Current Pharmacology Reports, 2017 The ever-increasing prevalence of metabolic diseases such as dyslipidemia and diabetes in the western world continues to be of great public health concern. Biologically active sphingolipids, such as sphingosine 1-phosphate (S1P) and ceramide, are important regulators of lipid metabolism.
Eric K. Kwong +3 more
openaire +2 more sources
Clinical Pharmacology in Drug Development, EarlyView.Abstract Mocravimod, a novel immunomodulator targeting sphingosine‐1‐phosphate receptor (S1PR), is being developed as a maintenance treatment for patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation. Preclinical data suggested that cytochrome (CYP) 3A4 is the primary enzyme involved in mocravimod metabolism.
Dymphy R. Huntjens +2 more
wiley +1 more source
The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease [PDF]
, 2010 The dramatic recent rise in the incidence of allergic or autoimmune inflammatory diseases in the West has been proposed to reflect the lack of appropriate priming of the immune response by infectious agents such as parasitic worms during childhood ...
Al-Riyami +111 more
core +2 more sources
Sphingosine kinase 1 in breast cancer: A new molecular marker and a therapy target [PDF]
, 2020 It is now well-established that sphingosine kinase 1 (SK1) plays a significant role in breast cancer development, progression, and spread, whereas SK1 knockdown can reverse these processes.
Alshaker, Heba +2 more
core +1 more source