Results 121 to 130 of about 102,609 (313)

The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer

Mediators of Inflammation, 2017
Inflammation is part of our body's response to tissue injury and pathogens. It helps to recruit various immune cells to the site of inflammation and activates the production of mediators to mobilize systemic protective processes.
N. Hait, A. Maiti
semanticscholar   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery

Biomolecules & Therapeutics, 2017
Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G protein-coupled receptors, S1P1–5.
Soojin Park, D. Im
semanticscholar   +1 more source

Lymph‐based liquid biopsy: Current progress and future potential

Interdisciplinary Medicine, EarlyView.
Recent evidence under the revised Starling principle indicates that lymph‐based liquid biopsies may offer superior diagnostic performance over blood‐based counterparts in certain clinical scenarios, such as early‐stage solid tumor detection. Currently, various biomarkers within the lymphatic system show significant diagnostic potential for a range of ...
Dongdong Liu, Leheng Cheng, Xiaolin Hu, Sergio Bernardini, Hong Zhang, Ling Zhu, Yang Luo   +6 more
wiley   +1 more source

Changes in Plasma Sphingolipid Metabolites Following Roux‐En‐Y Gastric Bypass in Women With Obesity and Type 2 Diabetes: A Pilot Metabolomic Cohort Study

Lipids, EarlyView.
ABSTRACT Although sphingolipids are key players in lipotoxicity and metabolic diseases, their response to bariatric surgery and their relation to metabolic improvement remain unclear. This pilot study investigated plasma sphingolipid remodeling after Roux‐en‐Y gastric bypass (RYGB) and its associations with clinical and biochemical markers of ...
Gabriela de Oliveira Lemos, Raquel Susana Torrinhas, Natasha Mendonça Machado, Dan Linetzky Waitzberg   +3 more
wiley   +1 more source

Regulation of Cytoskeleton Organization by Sphingosine in a Mouse Cell Model of Progressive Ovarian Cancer

Biomolecules, 2013
Ovarian cancer is a multigenic disease and molecular events driving ovarian cancer progression are not well established. We have previously reported the dysregulation of the cytoskeleton during ovarian cancer progression in a syngeneic mouse cell model ...
Eva M. Schmelz, Paul C. Roberts, Bradley P. Brayfield, Amy L. Creekmore, C. Lynn Heffron   +4 more
doaj   +1 more source

Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin. [PDF]

, 2019
Maintenance of a population of IL-17-committed γδ T cells in the dermis is important in promoting tissue immunity. However, the signals facilitating γδ T cell retention within the dermis remain poorly understood.
Cyster, Jason G, Gray, Elizabeth E, Laidlaw, Brian J, Ramírez-Valle, Francisco, Zhang, Yang   +4 more
core   +1 more source

Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome

Journal of Clinical Investigation, 2017
Primary adrenal insufficiency is life threatening and can present alone or in combination with other comorbidities. Here, we have described a primary adrenal insufficiency syndrome and steroid-resistant nephrotic syndrome caused by loss-of-function ...
R. Prasad, Irene Hadjidemetriou, A. Maharaj, Eirini Meimaridou, Federica Buonocore, Moin A. Saleem, Jenny Hurcombe, A. Bierzynska, Eliana Barbagelata, I. Bergadá, H. Cassinelli, Urmi Das, R. Krone, B. Hacıhamdioğlu, E. Sarı, E. Yeşilkaya, H. Storr, María Clemente, M. Fernández-Cancio, N. Camats, Nanik Ram, J. Achermann, Paul P. Van Veldhoven, L. Guasti, D. Braslavsky, T. Guran, Louise A Metherell   +26 more
semanticscholar   +1 more source

Peripheral versus Marrow Lipidomics in Patients with Severe Aplastic Anemia: Potential Indicators for Early Immunosuppressive Treatment Response

Lipids, EarlyView.
ABSTRACT This study aimed to explore the differences of peripheral blood (PB) and bone marrow serum lipidomic profiles in severe aplastic anemia (SAA) patients and their significance in predicting earlier immunosuppressive therapy (IST) response. A cohort of 11 newly diagnosed SAA patients and 15 healthy controls were enrolled between June 2020 and ...
Zexing Sun, Yilei Hong, Yaonan Hong, Chuanao Xin, Qi Liu, Huijin Hu, Yingying Shen, Ying Chen, Shan Liu, Yiping Shen, Yuhong Zhou, Dijiong Wu   +11 more
wiley   +1 more source

Identification of a xylose-containing cerebroside in the salt gland of the herring gull

Journal of Lipid Research, 1972
A pentose-containing cerebroside has been identified in the salt gland of the herring gull, using mass spectrometry of acetyl and trimethylsilyl derivatives.
Karl-Anders Karlsson, Bo E. Samuelsson, Göran O. Steen   +2 more
doaj   +1 more source