Results 131 to 140 of about 102,609 (313)
Frontiers in Immunology, 2018 Background: The pathophysiology of non-alcoholic steatohepatitis involves hepatocyte lipotoxicity due to excess saturated free fatty acids and concomitant proinflammatory macrophage effector responses.
Chieh-Yu Liao +5 more
semanticscholar +1 more source
Advancements in Mass Spectrometry‐Based Glycomics in Food and Nutritional Science
Mass Spectrometry Reviews, EarlyView.ABSTRACT This review highlights advancements in mass spectrometry (MS)‐based glycomics in food and nutritional science. Carbohydrates, which are vital for human health, exhibit complex structures, making their analysis challenging. MS has become an indispensable tool for elucidating the structures of carbohydrates, including glycans, through soft ...
JaeHui Song +3 more
wiley +1 more source
Acta Dermato-Venereologica, 2019 Sphingosine-1-phosphate (S1P) is a signalling sphingolipid metabolite that regulates important cell processes, including cell proliferation and apoptosis.
S. Shin +8 more
semanticscholar +1 more source
Studies on Sphingosines. 9. C19-Sphingosines, hitherto Unknown Sphingosines. [PDF]
Acta Chemica Scandinavica, 1965 Karl-Anders Karlsson +5 more
openaire +2 more sources
Med Research, EarlyView.ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang +22 more
wiley +1 more source
The role of sphingosine-1-phosphate in the tumor microenvironment and its clinical implications
Tumor Biology, 2017 Elucidating the interaction between cancer and non-cancer cells, such as blood vessels, immune cells, and other stromal cells, in the tumor microenvironment is imperative in understanding the mechanisms underlying cancer progression and metastasis, which
Masato Nakajima +4 more
doaj +1 more source
Serine-Dependent Sphingolipid Synthesis Is a Metabolic Liability of Aneuploid Cells
Cell Reports, 2017 Aneuploidy disrupts cellular homeostasis. However, the molecular mechanisms underlying the physiological responses and adaptation to aneuploidy are not well understood.
Sunyoung Hwang +10 more
doaj +1 more source
Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids
Movement Disorders, EarlyView.Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley +1 more source
Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases
Journal of Lipid Research, 2019 Sphingolipids contribute to the regulation of cell and tissue homeostasis, and disorders of sphingolipid metabolism lead to diseases such as inflammation, stroke, diabetes, and cancer.
Wataru Sakamoto +7 more
doaj +1 more source
Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia
Journal of molecular medicine, 2019 Ventilator-associated pneumonia (VAP) is a major cause of morbidity and mortality in critically ill patients. Here, we employed the broad antibacterial effects of sphingosine to prevent VAP by developing a novel method of coating surfaces of endotracheal
A. Seitz +12 more
semanticscholar +1 more source