Results 131 to 140 of about 66,817 (240)

Internalization of Exogenous Myelin by Oligodendroglia Promotes Lineage Progression

Glia, Volume 74, Issue 3, March 2026.
Oligodendroglia internalize extracellular myelin debris in vitro and in vivo. Internalized myelin modulates lipid metabolism and lipid droplet formation. Myelin‐derived signals promote oligodendroglial proliferation and lineage progression. ABSTRACT Oligodendrocytes, traditionally recognized for their role in central nervous system myelination, have ...
Carla Peiró‐Moreno, Juan Carlos Chara, Katy Marshall‐Phelps, Irune Ugarte‐Arakistain, Stefano Calovi, Rafael Gois De Almeida, María Domercq, Carlos Matute   +7 more
wiley   +1 more source

A Role of the ABCC4 Gene Polymorphism in Airway Inflammation of Asthmatics

Mediators of Inflammation, 2017
The ATP-binding cassette subfamily C member 4 gene encodes a transmembrane protein involved in the export of proinflammatory molecules, including leukotriene, prostaglandin, and sphingosine-1-phosphate across the plasma membrane.
Sailesh Palikhe, Udval Uuganbayar, Hoang Kim Tu Trinh, Ga-Young Ban, Eun-Mi Yang, Hae-Sim Park, Seung-Hyun Kim   +6 more
doaj   +1 more source

Functional Training Mitigates Reduced Circulating Indole‐3‐Lactate Levels in Persons With Relapsing–Remitting Multiple Sclerosis

Acta Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Aim Indoles are tryptophan (Trp)‐derived metabolites that are produced by the gut microbiota and may influence the gut‐microbiota‐brain axis in multiple sclerosis (MS). Indole‐3‐lactate (ILA) is reduced in persons with MS and improves MS clinical scores in animal models via its anti‐inflammatory remyelinating properties.
Tiffany Wences Chirino, Frederike Adammek, Sergen Belen, Matteo Winker, Sebastian Proschinger, Annette Rademacher, Marit L. Schlagheck, Alexander Schenk, Marie Kupjetz, David Walzik, Clemens Warnke, Marcel Reuter, Friederike Rosenberger, Tim Meyer, Adrian McCann, Per Magne Ueland, Niklas Joisten, Philipp Zimmer   +17 more
wiley   +1 more source

Defective high‐density lipoprotein lipoprotection in type 2 diabetes during acute myocardial infarction is rescued by apolipoprotein M/sphingosine‐1‐phosphate loading

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 2175-2182, March 2026.
Abstract Aims Mortality of patients with type 2 diabetes (T2D) after acute myocardial infarction (AMI) is tremendous and massively increased compared to non‐T2D individuals. The reasons are unclear. High‐density lipoprotein (HDL) conducts lipoprotection during AMI, leading to improved outcomes.
Jens Vogt, Marcel Benkhoff, Nathalie H. Schröder, Hao Hu, Lisa Dannenberg, Petra Keul, Theresia Sarabhai, Kálmán Benedikt Bódis, Tobias Zeus, Philipp Wollnitzke, Malte Kelm, Amin Polzin, Bodo Levkau   +12 more
wiley   +1 more source

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Although it has become clear that alterations in lipid metabolism are associated with Alzheimer's disease (AD), it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. METHODS Lipidomics and activity‐based protein profiling (ABPP) were performed in the frontal cortex of control, AD and resilient ...
Daan van der Vliet, Luuk E. de Vries, Xinyu Di, Dennis Wever, Brechtje de Jong, Marc T. C. van der Meij, Marielle van der Peet, Amy C. Harms, Thomas Hankemeier, Dick F. Swaab, Inge Huitinga, Joost Verhaagen, Mario van der Stelt   +12 more
wiley   +1 more source

The G protein-coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination. [PDF]

, 2015
The orphan Gα13-coupled receptor P2RY8 is mutated in human germinal center (GC)-derived lymphomas and was recently found to promote B cell association with GCs in a mouse model. Here we establish that P2RY8 promotes clustering of activated B cells within
Cyster, Jason G, Lu, Erick, Muppidi, Jagan R   +2 more
core  

Comorbidities at MS Diagnosis and Their Association With Treatment Persistence: Real‐World Clinical Data

Brain and Behavior, Volume 16, Issue 2, February 2026.
Comorbidity was present in approximately half of the patients with relapsing‐remitting multiple sclerosis in this Finnish cross‐sectional cohort. Comorbidities, especially psychiatric diseases, were associated with lower persistence on injectable disease‐modifying treatments.
Henrik Ahvenjärvi, Ida Lund, Anne M. Portaankorva, Johanna Krüger, Mervi Ryytty   +4 more
wiley   +1 more source

Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence. [PDF]

, 2019
Although aging is considered to be an unavoidable event, recent experimental evidence suggests that the process can be counteracted. Intracellular calcium (Ca2+i) dyshomeostasis, mitochondrial dysfunction, oxidative stress, and lipid dysregulation are ...
Bomba, Manuela, Castelli, Vanessa, Cicalini, Ilaria, Cimini, Annamaria, d'Aurora, Marco, Del Boccio, Piero, Gatta, Valentina, Granzotto, Alberto, Massetti, Noemi, Navarra, Riccardo, Onofrj, Marco, Piomelli, Daniele, Sensi, Stefano L   +12 more
core  

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Exocarpium Citri Grandis‐Derived Extracellular Vesicle‐Like Particles for Accelerating Wound Healing via Regulating the Protein Expression on the VEGF/AKT Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Our findings indicate that ECG‐EVLP can effectively promote wound healing and the activation of the VEGF/AKT signaling pathway in vitro and in vivo, coupled with the inhibition of the mitochondrial apoptosis pathway in cells following ECG‐EVLP stimulation might be its underlying mechanism.
Yingjie Xiong, Zanxiang Luo, Jingxiu Zhao, Chengshi Fu, Yujia Song, Jinyong He, Jiahui Gao, Zejie Su, Lie Liu, Xiangyun Teng, Jianhua Xu   +10 more
wiley   +1 more source