Results 1 to 10 of about 50,711 (247)

The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis [PDF]

Cells, 2023
Psoriasis is a long-lasting skin condition characterized by redness and thick silver scales on the skin’s surface. It involves various skin cells, including keratinocytes, dendritic cells, T lymphocytes, and neutrophils.
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Anna Di Nardo   +2 more
doaj   +6 more sources

Fingolimod modulates microglial activation to augment markers of remyelination [PDF]

Journal of Neuroinflammation, 2011
Introduction Microglial activation in multiple sclerosis has been postulated to contribute to long-term neurodegeneration during disease. Fingolimod has been shown to impact on the relapsing remitting phase of disease by modulating autoreactive T-cell ...
Baker David, Giovannoni Gavin, Jackson Samuel J   +2 more
doaj   +5 more sources

Sphingosine 1-phosphate receptor 2 in keratinocytes plays a key role in reducing inflammation in psoriasis [PDF]

Frontiers in Immunology
BackgroundPsoriasis is an inflammatory skin condition where immune cells play a significant role. The importance of the cross-talk between keratinocytes and immune cells in the pathogenesis of psoriasis has recently been reaffirmed.
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Samantha Lowry, Anna Di Nardo   +3 more
doaj   +2 more sources

Sphingosine-1-phosphate receptor 1/5 selective agonist alleviates ocular vascular pathologies [PDF]

Scientific Reports
Ocular abnormal angiogenesis and edema are featured in several ocular diseases. S1P signaling via S1P1 likely is part of the negative feedback mechanism necessary to maintain vascular health.
Shinsuke Nakamura, Rie Yamamoto, Takaya Matsuda, Hiroto Yasuda, Anri Nishinaka, Kei Takahashi, Yuki Inoue, Sadao Kuromitsu, Masamitsu Shimazawa, Masahide Goto, Shuh Narumiya, Hideaki Hara   +11 more
doaj   +2 more sources

Sphingosine 1-phosphate modulates antigen capture by murine langerhans cells via the S1P2 receptor subtype [PDF]

, 2012
Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and present it to T lymphocytes in the lymphoid organs.
A Kihara, A Kissenpfennig, A Kumar, A Martino, A Olivera, A Weigert, AD Christensen, Burkhard Kleuser, C Ocana-Morgner, C Ruedl, CC Norbury, CL Bennett, CL Bennett, DH Kaplan, DH Kaplan, E Guaguere, ES Trombetta, EY Seo, F Sparber, G Gollmann, G Schuhmachers, H Hackstein, H Liu, Heinfried H. Radeke, HH Radeke, I Reines, J Chun, Jagadeesh Bayry, JH Hong, K Kabashima, K Sarkar, K Takabe, Katrin Schaper, L Japtok, L Rose, L Ruwisch, LS Bursch, Lukasz Japtok, M Hara-Chikuma, M Matloubian, M Schröder, M Schuppel, MB Lutz, MC Kerr, ML Allende, ML Allende, N Romani, P Mitra, P Monti, R van de Ven, RH Kim, RM Steinman, S Spiegel, S Sullivan, S Xu, Se Kyoo Jeong, SH Wood, SP Zahner, T Hla, T Kitajima, T Walzer, V Brinkmann, W Baumer, W Baumer, W Baumer, Wolfgang Bäumer, Y Maeda, Y Yanagawa, YY Lan   +68 more
core   +12 more sources

Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. [PDF]

PLoS ONE, 2011
Ovarian transplantation is one of the key approaches to restoring fertility in women who became menopausal as a result of cancer treatments. A major limitation of human ovarian transplants is massive follicular loss during revascularization.
Reza Soleimani, Elke Heytens, Kutluk Oktay   +2 more
doaj   +1 more source

Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1

ESC Heart Failure, 2023
Aims Therapeutic options targeting post‐ischaemic cardiac remodelling are sparse. The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) reduces ischaemia/reperfusion injury.
Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, Maike Barcik, Petra Keul, Aysel Ayhan, Sarah Weske, Samantha Ahlbrecht, Kajetan Trojovsky, Carolin Helten, Sebastian Haberkorn, Ulrich Flögel, Tobias Zeus, Tina Müller, Markus H. Gräler, Malte Kelm, Bodo Levkau   +16 more
doaj   +1 more source

Sphingosine-1-Phosphate Signaling in Cardiovascular Diseases

Biomolecules, 2023
Sphingosine-1-phosphate (S1P) is an important sphingolipid molecule involved in regulating cardiovascular functions in physiological and pathological conditions by binding and activating the three G protein-coupled receptors (S1PR1, S1PR2, and S1PR3 ...
Na Wang, Jing-Yi Li, Bo Zeng, Gui-Lan Chen   +3 more
doaj   +1 more source

Insulin protects apoptotic cardiomyocytes from hypoxia/reoxygenation injury through the sphingosine kinase/sphingosine 1-phosphate axis. [PDF]

PLoS ONE, 2013
OBJECTIVE: Experimental and clinical studies have shown that administration of insulin during reperfusion is cardioprotective, but the mechanisms underlying this effect are still unknown.
Huan Yu, Xiangxin Che, Xiaoyuan Xu, Meirong Zheng, Yong Zhao, Wei He, Jingmou Yu, Jianjun Xiong, Weidong Li   +8 more
doaj   +1 more source

Does Siponimod Exert Direct Effects in the Central Nervous System?

Cells, 2020
The modulation of the sphingosine 1-phosphate receptor is an approved treatment for relapsing multiple sclerosis because of its anti-inflammatory effect of retaining lymphocytes in lymph nodes.
Markus Kipp
doaj   +1 more source