Results 111 to 120 of about 526,512 (229)
Obesity Modifies Sphingolipid Signatures in Childhood Asthma
Clinical &Experimental Allergy, EarlyView.
Harshita Shailesh +7 more
wiley +1 more source
MedComm, Volume 7, Issue 10, October 2026.Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna +3 more
wiley +1 more source
Sphingosine-1-Phosphate and Macrophage Biology—How the Sphinx Tames the Big Eater
Frontiers in Immunology, 2019 The sphingolipid sphingosine-1-phosphate (S1P) is produced by sphingosine kinases to either signal through intracellular targets or to activate a family of specific G-protein-coupled receptors (S1PR).
Andreas Weigert +5 more
doaj +1 more source
MedComm, Volume 7, Issue 10, October 2026.High‐altitude hypobaric hypoxia activates multiorgan GPCR signaling networks that regulate ventilatory responses, cerebral endothelial barrier integrity, erythropoiesis and red blood cell metabolism, pulmonary vascular remodeling, and cardiac adaptation. Dysregulated GPCR pathways contribute to acute and chronic high‐altitude diseases, while clinically
Qing Zhao +13 more
wiley +1 more source
Immune‐Cell Dynamics in the Tumor Microenvironment: Implications for Cancer Therapy
MedComm, Volume 7, Issue 10, October 2026.Immune‐cell dynamics in the tumor microenvironment converge on four major barriers to effective therapy: failed immune access, defective antigen visibility and priming, loss of effector maintenance, and suppressive tissue remodeling. These barriers emerge from local hypoxic, cytokine, metabolic, and stromal signals.
Pin Guo +8 more
wiley +1 more source
La sphingosine kinase 1 : rôle dans la stéatose hépatique
, 2017 Sphingosine kinase-1: role in non alcoholic fatty liver disease Implication of enzyme as sphingosine 1 kinase, sphingosine 1 phosphate and PPAR gamma in hepatic ...
Pruvost, R (via Mendeley Data)
core +1 more source
FASEB BioAdvances, Volume 8, Issue 10, October 2026.In salt‐loaded, hypertensive diabetic db/db mice with diabetic kidney disease, dapagliflozin lowered blood pressure and reduced tubular and glomerular injury. Mechanistically, dapagliflozin increased cullin E3 ligase abundance, promoting degradation of NKCC2.
Zenab Shahzad +5 more
wiley +1 more source
Role of Extracellular Vesicles in Shaping Immune Responses in the Lymph Node Microenvironment
Biology of the Cell, Volume 118, Issue 10, October 2026.Functional alliances of stromal, innate and adaptive immune cells in EV immunity in the lymph node. EV reflect the phenotype of their mother cell and cluster material from their surroundings. In the lymph node, EV preserve valuable context information between multiple cellular effectors to coordinate immunity in adaption to change.
Alicia Charrier +4 more
wiley +1 more source
International Endodontic Journal, Volume 59, Issue 10, Page 2211-2222, October 2026.ABSTRACT Aim The aim was to characterize the taxonomic and functional composition of the microbiome involved in primary endodontic infections and to evaluate their association with the periapical lesion size using shotgun metagenomic sequencing. Methodology Samples from primary root canal infections diagnosed with apical periodontitis were analysed ...
Virginia Pérez‐Carrasco +5 more
wiley +1 more source
Acid ceramidase-1 (ASAH1/aCDase) an important for anticancer drug discovery: a review
Future Journal of Pharmaceutical SciencesBackground Dysregulated sphingolipid metabolism has emerged as a major pathway in multiple human cancers. Sphingolipids are major structural components of cell membranes, playing key roles in maintaining structural integrity, fluidity, and barrier ...
Seemarani M. Pawar +2 more
doaj +1 more source