Results 101 to 110 of about 526,512 (229)

Sphingosine kinase and sphingosine 1-phosphate in the heart: A decade of progress [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013
Activation of sphingosine kinase/sphingosine 1-phosphate (SK/S1P)-mediated signaling has emerged as a critical cardioprotective pathway in response to acute ischemia/reperfusion injury. S1P is released in both ischemic pre- and post-conditioning. Application of exogenous S1P to cultured cardiac myocytes subjected to hypoxia or treatment of isolated ...
openaire   +4 more sources

Tripartite Interplay of Epithelial, Immune, and Microbiota Dysregulation in Crohn's Disease: Mechanisms and Translational Strategies

Immunity, Inflammation and Disease, Volume 14, Issue 10, October 2026.
ABSTRACT Background Crohn's disease (CD) is a multifactorial inflammatory bowel disease (IBD) characterized by impaired epithelial barrier integrity, excessive immune hyperactivation, and gut microbiota perturbations. Cumulative evidence supports the role of the intestinal epithelial barrier, immune system and gut microbiota in the progression of CD ...
Qing Lai, Qing‐Yun Zhang, Wei‐Peng Yang, Chun‐Ying Luo   +3 more
wiley   +1 more source

Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity[S]

Journal of Lipid Research, 2009
Studies in skeletal muscle demonstrate that elevation of plasma FFAs increases the sphingolipid ceramide. We aimed to determine the impact of FFA oversupply on total sphingolipid profiles in a skeletal muscle model.
Wei Hu, Jacek Bielawski, Fahumiya Samad, Alfred H. Merrill, Jr., L. Ashley Cowart   +4 more
doaj   +1 more source

Role of sphingosine kinase and sphingosine-1-phosphate in inflammatory arthritis

World Journal of Biological Chemistry, 2010
The importance of sphingosine kinase (SphK) and sphingosine-1-phosphate (S1P) in inflammation has been extensively demonstrated. As an intracellular second messenger, S1P plays an important role in calcium signaling and mobilization, and cell proliferation and survival.
Wen-Qi, Lai, Alirio J, Melendez, Bernard P, Leung   +2 more
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Estradiol Promotes Tumor Progression in ERα‐Low Endometrial Cancer via the GPER/SphK1 Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Estradiol (E2) promotes tumor progression in ERα‐low endometrial cancer through the GPER/SphK1/ERK1/2 signaling axis. E2 binding to GPER activates SphK1 and downstream ERK1/2, upregulating Cyclin D1, Cyclin E1, and MMP‐9 to drive cell proliferation, migration, and invasion.
Xiuwen Wang, Haofei Sun, Xin Wen, Weiwei Xin, Zhandong Hu, Zhongwei Zhao, Lizhi Zhang   +6 more
wiley   +1 more source

Sphingosine kinase localization in the control of sphingolipid metabolism

, 2011
Link to a related website: http://europepmc.org/articles/pmc3079002?pdf=render, Open Access via UnpaywallThe sphingosine kinases (sphingosine kinase-1 and -2) have been implicated in a variety of physiological functions.
Pitson, S., Skobeleva, A., Anderson, C., Anastasia Skobeleva, Viswanathan Natarajan, Siow, D., Deanna L. Siow, Natarajan, V., Evgeny V. Berdyshev, Charles D. Anderson, Wattenberg, B., Stuart M. Pitson, Binks W. Wattenberg, Berdyshev, E.   +13 more
core   +1 more source

Sphingosine kinase 1 deficiency exacerbates LPS-induced neuroinflammation.

PLoS ONE, 2012
The pathogenesis of inflammation in the central nervous system (CNS), which contributes to numerous neurodegenerative diseases and results in encephalopathy and neuroinflammation, is poorly understood.
Natalia M Grin'kina, Eddy E Karnabi, Dushyant Damania, Sunil Wadgaonkar, Ilham A Muslimov, Raj Wadgaonkar   +5 more
doaj   +1 more source

The Microbiome in Glioblastoma: Mechanisms, Tumor–Immune Interactions, and Translational Perspectives

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Proposed microbiome‐related pathways and translational landscape in glioblastoma. Gut dysbiosis may alter microbial metabolites, inflammatory mediators, barrier integrity, immune signaling, and vagal communication, thereby influencing the GBM neuroimmune microenvironment.
Tareq Nayef AlRamadneh, Renuka Jyothi‐S, Priya Priyadarshini‐Nayak, Anima Nanda, Shaker Al‐Hasnaawei, Akanksha Bhatt, Ashish Singh‐Chauhan, Siya Singla, Manoj Kumar Mishra   +8 more
wiley   +1 more source

An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes

, 2004
Sphingosine kinase catalyses the phosphorylation of sphingosine to generate sphingosine 1-phosphate, a lipid signaling molecule implicated in roles in a diverse range of mammalian cell processes through its action as both a ligand for G-protein-coupled ...
Pitson, S., Darrow, A., Moretti, P., Derian, C., Roberts, J., Vadas, M.   +5 more
core   +1 more source

Sphingosine Kinase 2, an Evil Kinase?

The FASEB Journal, 2008
Sphingosine 1‐phosphate (S1P) is a potent lipid mediator that regulates a variety of biological responses important for cancer progression. Two sphingosine kinase isozymes SphK1 and SphK2 control S1P levels. While SphK1 promotes growth and survival and has been linked to cancer progression, much less is known about the functions of SphK2.
Sarah Spiegel, Nitai C. Hait
openaire   +1 more source