Results 91 to 100 of about 30,128 (249)

Role of sphingosine kinase and sphingosine-1-phosphate in inflammatory arthritis

World Journal of Biological Chemistry, 2010
The importance of sphingosine kinase (SphK) and sphingosine-1-phosphate (S1P) in inflammation has been extensively demonstrated. As an intracellular second messenger, S1P plays an important role in calcium signaling and mobilization, and cell proliferation and survival.
Wen-Qi, Lai, Alirio J, Melendez, Bernard P, Leung   +2 more
openaire   +2 more sources

Darier disease—A review highlighting new insights from the Darier Disease International Task Force

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review provides a global, clinically focused overview of DD, detailing cutaneous and extracutaneous manifestations, disease classification and severity scoring. It emphasizes early recognition, multidisciplinary management and practical guidance for dermatologists to apply evidence‐based care in diverse skin phototypes. Abstract Darier disease (DD)
Sofia Labbouz, Alain Hovnanian, Grace Xiong, Dedee Frances Murrell, Simon M. Mueller, Khaled Ezzedine, Nessa Aghazadeh Mohandesi, Ahmed Salem Aldhaheri, Nissim Asayag, Eulalia Baselga, Chen Nadler, Keith Choate, Chia‐Yu Chu, John Robert Edminister, Emmanuella Guenova, Melis Gönülal, Antoni Gostynski, Ankan Gupta, Lalit Kumar Gupta, Juliette Mazereeuw‐Hautier, Wolfram Hoetzenecker, Peter Itin, Marek Jankowski, Akiharu Kubo, Haur Yueh Lee, Julia Scott Lehman, Anfisa Lepekhova, Márta Medvecz, Jemima E. Mellerio, Verena Moosbrugger‐Martinz, Amy S. Paller, Dóra Plázár, Amadeu José Rodrigues Queiróz, Josep Riera‐Monroig, Ralph Rosa, Matthias Schmuth, Maella Severino Freire, Itzhak Shabat, Jonathan Shapiro, Cory L. Simpson, Diego Soto‐García, Alexander J. Stratigos, Gianluca Abel Tadini, Takuya Takeichi, Kaushal K. Verma, Jakob D. Wikström, Alexander Zink, Michael Ziv, Alexander Navarini, Roni Pircha Dodiuk‐Gad   +49 more
wiley   +1 more source

Sphingosine kinase localization in the control of sphingolipid metabolism

, 2011
Link to a related website: http://europepmc.org/articles/pmc3079002?pdf=render, Open Access via UnpaywallThe sphingosine kinases (sphingosine kinase-1 and -2) have been implicated in a variety of physiological functions.
Pitson, S., Skobeleva, A., Anderson, C., Anastasia Skobeleva, Viswanathan Natarajan, Siow, D., Deanna L. Siow, Natarajan, V., Evgeny V. Berdyshev, Charles D. Anderson, Wattenberg, B., Stuart M. Pitson, Binks W. Wattenberg, Berdyshev, E.   +13 more
core   +1 more source

Asian Pacific Association of Gastroenterology (APAGE) Clinical Practice Guidelines on the Use of Small Molecules and IL‐23 p19 Inhibitors in Ulcerative Colitis and Crohn's Disease

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Ulcerative colitis (UC) and Crohn's disease (CD) are increasingly prevalent in the Asia Pacific region, necessitating updated, region‐specific guidance on advanced therapies. Targeted small molecule agents, such as filgotinib, tofacitinib, upadacitinib, etrasimod, and ozanimod; and the IL‐23 p19 inhibitors (guselkumab, mirikizumab ...
Choon Jin Ooi, Khoon Lin Ling, Julajak Limsrivilai, Shu‐Chen Wei, Joyce Wing Yan Mak, Taku Kobayashi, Luan Minh Dang, Rupert W. Leong, Huiyu Lin, Meng‐Tzu Weng, Wan Chee Ong, Vineet Ahuja, Satimai Aniwan, Ryota Hokari, Wei Jie Jonathan Lee, Alex Hwong‐Ruey Leow, Wai‐Keung Leung, Wee‐Chian Lim, Govind Makharia, Katsuyoshi Matsuoka, Nazri Mustaffa, Siew‐Chien Ng, Mathew Philip, Pises Pisespongsa, Raja Affendi Raja Ali, Zhi Hua Ran, Marcellus Simadibrata, Jose Sollano, Malcolm Tan, Hang Dao Viet, Nik Razima Wan Ibrahim, Kai Chun Wu, Byong Duk Ye, Ida Hilmi, Asian Pacific Association of Gastroenterology (APAGE) Inflammatory Bowel Disease Committee and Asian Education Network in IBD (AEN‐IBD)   +34 more
wiley   +1 more source

An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes

, 2004
Sphingosine kinase catalyses the phosphorylation of sphingosine to generate sphingosine 1-phosphate, a lipid signaling molecule implicated in roles in a diverse range of mammalian cell processes through its action as both a ligand for G-protein-coupled ...
Pitson, S., Darrow, A., Moretti, P., Derian, C., Roberts, J., Vadas, M.   +5 more
core   +1 more source

Sphingosine Kinase 2, an Evil Kinase?

The FASEB Journal, 2008
Sphingosine 1‐phosphate (S1P) is a potent lipid mediator that regulates a variety of biological responses important for cancer progression. Two sphingosine kinase isozymes SphK1 and SphK2 control S1P levels. While SphK1 promotes growth and survival and has been linked to cancer progression, much less is known about the functions of SphK2.
Sarah Spiegel, Nitai C. Hait
openaire   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Rôle de la sphingosine 1-phosphate dans les interactions mélanome-stroma

, 2012
Le mélanome métastatique demeure un cancer au sombre pronostic, et aucune des thérapies conventionnelles n'a pu apporter de bénéfice sur la survie globale.
Albinet, Virginie
core  

La sphingosine kinase 1 : rôle dans la stéatose hépatique

, 2017
Sphingosine kinase-1: role in non alcoholic fatty liver disease Implication of enzyme as sphingosine 1 kinase, sphingosine 1 phosphate and PPAR gamma in hepatic ...
Pruvost, R (via Mendeley Data)
core   +1 more source