Results 71 to 80 of about 30,128 (249)

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, EarlyView.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Sphingosine kinase 2 deficiency increases proliferation and migration of renal mouse mesangial cells and fibroblasts [PDF]

, 2015
Both of the sphingosine kinase (SK) subtypes SK-1 and SK-2 catalyze the production of the bioactive lipid molecule sphingosine 1-phosphate (S1P). However, the subtype-specific cellular functions are largely unknown.
Zangemeister-Wittke, Uwe, Hofmann, Lotte P, Ebadi, Mahsa, Filipenko, Iuliia, Pfeilschifter, Josef, Huwiler, Andrea, Maneva Timcheva, Tankica, Schwalm, Stephanie   +7 more
core   +1 more source

Role of Sphingosine-1-Phosphate in Mast Cell Functions and Asthma and Its Regulation by Non-Coding RNA

Frontiers in Immunology, 2017
Sphingolipid metabolites are emerging as important signaling molecules in allergic diseases specifically asthma. One of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), is involved in cell differentiation, proliferation, survival, migration ...
Rohit Saluja, Ashok Kumar, Manju Jain, Sudhir K. Goel, Aklank Jain   +4 more
doaj   +1 more source

Sphingosine Kinase: A Closer Look at Last [PDF]

Structure, 2013
Sphingosine-1-phosphate is a potent sphingolipid mediator, and the kinase that produces it, sphingosine kinase 1 (SphK1), has been implicated in cancer progression, inflammation, and cardiovascular diseases. In this issue of Structure, Wang and colleagues provide the scientific community with the long awaited structure of SphK1.
Lima, Santiago, Spiegel, Sarah
openaire   +2 more sources

Reconceptualizing Aplastic Anemia—Seed, Worm, Soil

Journal of Clinical Laboratory Analysis, EarlyView.
Aplastic anemia (AA) encompasses a group of hematological syndromes often misdiagnosed, resulting in a decrease in the overall blood cell count and representing a form of bone marrow failure. We reinterpret AA based on the “seed, worm, and soil” doctrine.
Xintong Xu, Zining Wang, Jiaming Hu, Chunyan Liu, Rong Fu   +4 more
wiley   +1 more source

The Inhibition of Sphingosine Kinase Using Modified Variants of Zone 2 of Sphingosine Kinase Inhibitor 1

, 2022
Sphingosine-1-phosphate is a bioactive lipid mediator that has been shown to play a critical role in cell migration, survival, and proliferation. It is phosphorylated from sphingosine, which has the opposite effect on cells.
Lewis, Jomar
core  

Regulation and function of sphingosine kinase 2 in diseases [PDF]

, 2018
Sphingosine kinase functions to phosphorylate sphingosine to sphingosine 1-phosphate (S1P) to keep balance in the metabolites of sphingolipids. There are two isoforms of sphingosine kinase, sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2).
Zhou, Jun Hao, Sheng, Rui, Song, Dan Dan
core   +1 more source

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells

, 2012
PPARγ agonists [thiazolidinediones (TZDs)] are known to exert anti-fibrotic effects in the kidney. In addition, we previously demonstrated that sphingosine kinase 1 (SK-1) and intracellular sphingosine-1-phosphate (S1P), by reducing the expression of ...
Wünsche, C, Koch, A, Völzke, A, Huwiler, A, Pfeilschifter, J, Meyer zu Heringdorf, D   +5 more
core   +1 more source

Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis [PDF]

, 2013
PMCID: PMC3539993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
I. Mavrommati, Piñeiro R, Chiozzotto, D, Tania Maffucci, G. Tibolla, Pineiro, R, Wheeler Ann P., Giuseppe Danilo Norata (104795), Wheeler, A., Ioanna Mavrommati, Maffucci Tania, Norata, G., Chiozzotto Daniela, Ioanna Mavrommati (104788), Tibolla Gianpaolo, Mavrommati, I, Maffucci, T, D. Chiozzotto, Falasca, M, Mavrommati Ioanna, Alberico Luigi Catapano, Roberto Piñeiro (104782), Mavrommati, I., Daniela Chiozzotto, Ann P Wheeler, R. Piñeiro, Gianpaolo Tibolla (104779), Norata GD, G.D. Norata, Norata Giuseppe Danilo, M. Falasca, Giuseppe Danilo Norata, Daniela Chiozzotto (104784), T. Maffucci, Catapano AL, Ann P. Wheeler (104791), Falasca Marco, Piñeiro Roberto, A.L. Catapano, Marco Falasca (104805), Chiozzotto D, Alberico Luigi Catapano (104799), Falasca, Marco, Wheeler AP, Falasca M, Maffucci T, Catapano, A., Mavrommati I, Norata, GD, Tibolla G, Piñeiro, R., Chiozzotto, D., Marco Falasca, Maffucci, T., Tibolla, G., Tibolla, G, Wheeler, AP, Roberto Piñeiro, Catapano Alberico Luigi, A. P. Wheeler, Gianpaolo Tibolla, Catapano, AL, Tania Maffucci (104802)   +62 more
core   +1 more source