Results 141 to 150 of about 30,128 (249)

Second‐generation prokineticin PKR1 receptor agonists: Advancing cardioprotection against chemotherapy‐induced toxicity

British Journal of Pharmacology, Volume 183, Issue 12, Page 3377-3394, June 2026.
IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand, Simone Brogi, Mustafa Tezeren, Andrea Tafi, Omer H. Ocak, Hasan Koyuncu, Igor Tetko, Laurent Désaubry, Canan G. Nebigil   +8 more
wiley   +1 more source

Regulation of arginase II expression in macrophages by supernatants of apoptotic cells

, 2010
Apoptotic cell (AC)-derived factors alter the physiology of macrophages (M Phi s) towards a regulatory phenotype that is characterized by enhanced production of anti-inflammatory mediators, an attenuated pro-inflammatory cytokine profile and reduced ...
Barra, Vera
core  

Stopping Sepsis by Targeting Sphingosine Kinase 1

, 2010
A recent study suggests that inhibiting the enzyme sphingosine kinase 1 might have great potential as a therapy for sepsis.
Luke A. J. O’Neill
core   +1 more source

Evaluation of Zone-4 Inhibitors Using Sphingosine Kinase Activity Assay

, 2017
Sphingosine kinase 1 is an enzyme that catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate, which is known to induce cell proliferation.
Smith, Mikala R.
core  

Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2

, 2007
In yeast, the long-chain sphingoid base phosphate phosphohydrolase Lcb3p is required for efficient ceramide synthesis from exogenous sphingoid bases.
H. Le Stunff, P. Giussani, S. Milstien, M. Maceyka, S. Spiegel, S. Lépine   +5 more
core   +1 more source

Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase.

The Journal of biological chemistry, 2000
Sphingosine kinase (SK) catalyzes the formation of sphingosine 1-phosphate (S1P), a lipid messenger that plays an important role in a variety of mammalian cell processes, including inhibition of apoptosis and stimulation of cell proliferation. Basal levels of S1P in cells are generally low but can increase rapidly when cells are exposed to various ...
S M, Pitson, P A, Moretti, J R, Zebol, P, Xia, J R, Gamble, M A, Vadas, R J, D'Andrea, B W, Wattenberg   +7 more
openaire   +1 more source

Roles of sphingosine 1-phosphate on tumorigenesis

, 2011
[[abstract]]Roles of sphingosine 1-phosphate on ...
黃元勵;Huang, Yuan-Li, Yuan-Li Huang
core   +1 more source

Use of a decoy peptide to purify p21 activated kinase-1 in cardiac muscle and identification of ceramide-related activation

Biologics: Targets & Therapy, 2008
Yunbo Ke, R John SolaroDepartment of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USAAbstract: The p21 activated kinase-1 (Pak1) is a serine-threonine protein kinase directly activated by ...
Yunbo Ke, R John Solaro
doaj  

Effect of sphingosine and phorbol-12-myristate-13-acetate on the growth and dimethylsulfoxide-induced differentiation in the insect trypanosomatid Herpetomonas samuelpessoai

Memorias do Instituto Oswaldo Cruz, 2007
We investigated the effect of two modulators of protein kinase C, sphingosine and phorbol-12-myristate-13-acetate (PMA), on the growth and dimethylsulfoxide (DMSO)-induced differentiation in Herpetomonas samuelpessoai.
André Luis Souza dos Santos, Rosangela Maria de Araújo Soares   +1 more
doaj  

Engineering of Saccharomyces cerevisiae as a platform strain for microbial production of sphingosine-1-phosphate

Microbial Cell Factories
Background Sphingosine-1-phosphate (S1P) is a multifunctional sphingolipid that has been implicated in regulating cellular activities in mammalian cells.
In-Seung Jang, Sung Jin Lee, Yong-Sun Bahn, Seung-Ho Baek, Byung Jo Yu   +4 more
doaj   +1 more source