Results 161 to 170 of about 27,038 (199)

Assessment of the Effects of Sphingosine Kinase 1/Sphingosine-1-Phosphate on Microangiogenesis at Rat Myofascial Trigger Points Using Contrast-Enhanced Ultrasonography. [PDF]

J Pain Res
Fang X, Yin Y, Lun H, Liu Y, Zhu S.
europepmc   +1 more source

Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model.

Am J Physiol Lung Cell Mol Physiol
Sudhadevi T, Ackerman SJ, Jafri A, Basa P, Ha AW, Natarajan V, Harijith A.   +6 more
europepmc   +1 more source

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Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
The sphingolipid metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and cell death. Cer and Sph usually inhibit proliferation and promote apoptosis, while the further metabolite S1P stimulates growth and suppresses apoptosis.
Michael, Maceyka, Shawn G, Payne, Sheldon, Milstien, Sarah, Spiegel   +3 more
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Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics

Prostaglandins & Other Lipid Mediators, 2005
It has become abundantly clear over the past decade that sphingolipids and their metabolites are key signaling molecules. Ceramide, the backbone of all sphingolipids, predominantly inhibits cell growth and induces apoptosis, while its metabolite, sphingosine-1-phosphate promotes growth and survival.
Michael, Maceyka, Sheldon, Milstien, Sarah, Spiegel   +2 more
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A rapid radioassay for sphingosine kinase

Analytical Biochemistry, 2005
A solvent-extraction-based radioassay for measuring sphingosine kinase (SKase) activity has been developed. The assay utilizes [3H]sphingosine substrate and differentially extracts the [3H]sphingosine-1-phosphate product. The extracted radioactivity is demonstrated to be primarily [3H]sphingosine-1-phosphate with less than 1% contamination by [3H ...
Donald A, Vessey, M, Kelley, Joel S, Karliner   +2 more
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Sphingosine Kinases Signalling in Carcinogenesis

Mini-Reviews in Medicinal Chemistry, 2015
Sphingosine kinases (Sphk1 and 2) regulate the prodution of sphingosine-1-phosphate (S1P), that is key molecule in cancer development. SphK1, which is commonly overexpressed in malignant tumours, significantly contributes to the pathogenesis of various types of cancer as well as to resistance to different Tyrosine Kinase inibitors (TKIs).
Gabriella, Marfe, Giovanna, Mirone, Arvind, Shukla, Carla, Di Stefano   +3 more
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Synthesis and Evaluation of Sphingosine Analogues as Inhibitors of Sphingosine Kinases

Journal of Medicinal Chemistry, 2009
Sphingolipid-metabolizing enzymes control the critical balance of the cellular levels of sphingolipids, including the apoptotic inducing ceramide (Cer) and the proliferative inducing sphingosine 1-phosphate (S1P). The production of S1P, catalyzed by the action of sphingosine kinases (SPHKs), is known to be critical for many cellular processes. However,
Wong, L., Tan, S.S.L., Lam, Y., Melendez, A.J.   +3 more
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Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway

2013
Sphingolipids have emerged as pleiotropic signaling molecules with roles in numerous cellular and biological functions. Defining the regulatory mechanisms governing sphingolipid metabolism is crucial in order to develop a complete understanding of the biological functions of sphingolipid metabolites.
K Alexa Orr, Gandy, Lina M, Obeid
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Sphingosine kinases: A novel family of lipid kinases

2002
Sphingosine kinase (SPHK) catalyzes the formation of sphingosine-1-phosphate (S11). S1P plays an important role in regulation of a variety of biological processes through intracellular and extracellular actions. S1P has recently been shown to be the ligand for the EDG-1 family of G-protein-coupled receptors.
Hong, Liu, Debyani, Chakravarty, Michael, Maceyka, Sheldon, Milstien, Sarah, Spiegel   +4 more
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