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Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2
Bioorganic & Medicinal Chemistry Letters, 2004Fluorescently labeled d-erythro-sphingosines have been successfully synthesized in 9 and 12 steps starting from commercially available Garner aldehyde. Determining the influence of the nature, position and linkage of the label on the in vitro phosphorylation rate by sphingosine kinases 1 and 2 resulted in the identification of a pyrene- and a NBD ...
Peter, Ettmayer +5 more
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Chemistry and Physics of Lipids, 2016
Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. Among them, sphingosine 1 phosphate (S1P) is a recognized promoter of cell survival, also involved, inter alia, in inflammation and tumorigenesis processes. The knowledge and modulation of the enzymes implicated in the biosynthesis and degradation of S1P are ...
Pol, Sanllehí +3 more
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Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. Among them, sphingosine 1 phosphate (S1P) is a recognized promoter of cell survival, also involved, inter alia, in inflammation and tumorigenesis processes. The knowledge and modulation of the enzymes implicated in the biosynthesis and degradation of S1P are ...
Pol, Sanllehí +3 more
openaire +2 more sources
Sphingosine Kinase in Blood Platelets
Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1973W, Stoffel, G, Heimann, B, Hellenbroich
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Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation
EMBO Journal, 2003Stuart Pitson, Pu Xia, Paul Moretti
exaly