Results 151 to 160 of about 30,128 (249)

Synthesis and Analysis of Potential Sphingosine Kinase 1 Inhibitors

, 2018
The sphinogmyelin metabolic pathway is a popular target area of research due to the potential for apoptosis in cancer cells. In the pathway, sphinogmyelin may be converted to the final product of sphingosine-1-phosphate.
Manore, Sara
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Optimizing the Production of Sphingosine Kinase

, 2018
A metabolizing agent known as sphingosine kinase (SphK) phosphorylates the lipid molecule sphingosine, thereby converting it to sphingosine-1-phosphate (S1P).
Jeelani, Faraz Ahmed
core  

S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer

Clinical and Experimental Gastroenterology, 2014
Emilie Degagné, Julie D Saba Children's Hospital Oakland Research Institute, Oakland, CA, USA Abstract: Inflammatory bowel disease (IBD) is a complex disease that involves unpredictable and destructive inflammation in the gastrointestinal ...
Degagné E, Saba JD
doaj  

Targeting sphingosine kinase 1 in p53KO thymic lymphoma. [PDF]

FASEB J, 2023
Velazquez FN, Stith JL, Zhang L, Allam AM, Haley J, Obeid LM, Snider AJ, Hannun YA.   +7 more
europepmc   +1 more source

Integrative roles of sphingosine kinase in liver pathophysiology. [PDF]

Toxicol Res, 2023
Kim KM, Shin EJ, Yang JH, Ki SH.
europepmc   +1 more source

Activation of sphingosine kinase by the bradykinin B2 receptor and its implication in regulation of the ERK/MAP kinase pathway

, 2001
Sphingosine kinase phosphorylates sphingosine to generate sphingosine 1-phosphate, a phospholipid that has been implicated in signaling by a number of transmembrane receptors and was recently shown to act as a ligand for a specific class of G protein ...
Dikic, Ivan,, Blaukat, Andree
core  

Therapeutic potential of the sphingosine kinase 2 inhibitor opaganib. [PDF]

Pharm Sci Adv
Huang F, Zhan P, Shi X, Sun Y, Song X, Sun P, Liu B.   +6 more
europepmc   +1 more source

Vascular Sphingosine Kinase 1 Regulates Angiotensin II-Induced Hypertension. [PDF]

Hypertension
Jozefczuk E, Szczepaniak P, Mikolajczyk TP, Nosalski R, Dziedzic M, Urbanski K, Wojciechowska E, Filip G, Stefanska M, Blyszczuk P, Guzik TJ, Siedlinski M.   +11 more
europepmc   +1 more source

UCHL1 Regulates Radiation Lung Injury via Sphingosine Kinase-1. [PDF]

Cells, 2023
Epshtein Y, Mathew B, Chen W, Jacobson JR.   +3 more
europepmc   +1 more source

The molecular mechanism of sphingosine kinase activation

Many cell processes like growth, death and differentiation are controlled by hormones and other molecules that interact with receptors on the outside of the cell.

core