Results 181 to 190 of about 526,512 (229)

Combined Antitumor Effect of the Serine Protease Urokinase Inhibitor Upamostat and the Sphingosine Kinase 2 Inhibitor Opaganib on Cholangiocarcinoma Patient-Derived Xenografts. [PDF]

Cancers (Basel)
Asumda FZ, Campbell NA, Hassan MA, Fathi R, Vasquez Rico DF, Kiem M, Vang EV, Kim YH, Luo X, O'Brien DR, Buhrow SA, Reid JM, Moore MJ, Ben-Yair VK, Levitt ML, Leiting JL, Abdelrahman AM, Zhu X, Lucien F, Truty MJ, Roberts LR.   +20 more
europepmc   +1 more source

Expression of Concern: miRNA-103 promotes chondrocyte apoptosis by downregulation of Sphingosine kinase-1 and ameliorates PI3K/AKT pathway in osteoarthritis. [PDF]

Biosci Rep
europepmc   +1 more source

Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model.

Am J Physiol Lung Cell Mol Physiol
Sudhadevi T, Ackerman SJ, Jafri A, Basa P, Ha AW, Natarajan V, Harijith A.   +6 more
europepmc   +1 more source

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Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2002
The sphingolipid metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and cell death. Cer and Sph usually inhibit proliferation and promote apoptosis, while the further metabolite S1P stimulates growth and suppresses apoptosis.
Sarah Spiegel, Shawn G Payne
exaly   +3 more sources

Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival

British Journal of Pharmacology, 2012
Sphingosine kinase 1 catalyses formation of the bioactive lipid, sphingosine 1-phosphate, which protects cancer cells from apoptosis. Therefore, sphingosine kinase 1 is a novel target for intervention with anti-cancer agents.
Nigel J Pyne, Susan Pyne, Keng Gat Lim
exaly   +5 more sources

Activation of sphingosine kinase 1 by ERK1/2‐mediated phosphorylation [PDF]

EMBO Journal, 2003
Copyright © 2003 European Molecular Biology OrganizationSphingosine kinase 1 is an agonist-activated signalling enzyme that catalyses the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in a number of agonist ...
Stuart M Pitson, Pu Xia, Paul Moretti
exaly   +2 more sources

Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics

Prostaglandins & Other Lipid Mediators, 2005
It has become abundantly clear over the past decade that sphingolipids and their metabolites are key signaling molecules. Ceramide, the backbone of all sphingolipids, predominantly inhibits cell growth and induces apoptosis, while its metabolite, sphingosine-1-phosphate promotes growth and survival.
Michael, Maceyka, Sheldon, Milstien, Sarah, Spiegel   +2 more
openaire   +2 more sources

Functional characterization of human sphingosine kinase-1 [PDF]

FEBS Letters, 2000
Sphingosine kinase catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a novel lipid mediator with both intra- and extracellular functions.
Sarah Spiegel, Víctor E Nava, Takafumi Kohama   +2 more
exaly   +2 more sources

A rapid radioassay for sphingosine kinase

Analytical Biochemistry, 2005
A solvent-extraction-based radioassay for measuring sphingosine kinase (SKase) activity has been developed. The assay utilizes [3H]sphingosine substrate and differentially extracts the [3H]sphingosine-1-phosphate product. The extracted radioactivity is demonstrated to be primarily [3H]sphingosine-1-phosphate with less than 1% contamination by [3H ...
Donald A, Vessey, M, Kelley, Joel S, Karliner   +2 more
openaire   +2 more sources