Results 201 to 210 of about 30,128 (249)

5-Fluorouracil resistance due to sphingosine kinase 2 overexpression in colorectal cancer is associated with myeloid-derived suppressor cell-mediated immunosuppressive effects. [PDF]

BMC Cancer
Li X, Chen Y, Liang Y, Shi W.
europepmc   +1 more source

Combating Acute Myeloid Leukemia via Sphingosine Kinase 1 Inhibitor-Nanomedicine Combination Therapy with Cytarabine or Venetoclax. [PDF]

Pharmaceutics
Nguyen TM, Joyce P, Ross DM, Bremmell K, Jambhrunkar M, Wong SS, Prestidge CA.   +6 more
europepmc   +1 more source

Combined Antitumor Effect of the Serine Protease Urokinase Inhibitor Upamostat and the Sphingosine Kinase 2 Inhibitor Opaganib on Cholangiocarcinoma Patient-Derived Xenografts. [PDF]

Cancers (Basel)
Asumda FZ, Campbell NA, Hassan MA, Fathi R, Vasquez Rico DF, Kiem M, Vang EV, Kim YH, Luo X, O'Brien DR, Buhrow SA, Reid JM, Moore MJ, Ben-Yair VK, Levitt ML, Leiting JL, Abdelrahman AM, Zhu X, Lucien F, Truty MJ, Roberts LR.   +20 more
europepmc   +1 more source

Expression of Concern: miRNA-103 promotes chondrocyte apoptosis by downregulation of Sphingosine kinase-1 and ameliorates PI3K/AKT pathway in osteoarthritis. [PDF]

Biosci Rep
europepmc   +1 more source

Inhibition of Sphingosine Kinase 1 Reduces Sphingosine-1-Phosphate and Exacerbates Amyloid-Beta-Induced Neuronal Cell Death in Mixed-Glial-Cell Culture. [PDF]

Neurol Int
Minamihata T, Takano-Kawabe K, Moriyama M.   +2 more
europepmc   +1 more source

Assessment of the Effects of Sphingosine Kinase 1/Sphingosine-1-Phosphate on Microangiogenesis at Rat Myofascial Trigger Points Using Contrast-Enhanced Ultrasonography. [PDF]

J Pain Res
Fang X, Yin Y, Lun H, Liu Y, Zhu S.
europepmc   +1 more source

Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model.

Am J Physiol Lung Cell Mol Physiol
Sudhadevi T, Ackerman SJ, Jafri A, Basa P, Ha AW, Natarajan V, Harijith A.   +6 more
europepmc   +1 more source

Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival

British Journal of Pharmacology, 2012
Sphingosine kinase 1 catalyses formation of the bioactive lipid, sphingosine 1-phosphate, which protects cancer cells from apoptosis. Therefore, sphingosine kinase 1 is a novel target for intervention with anti-cancer agents.
Keng Gat Lim, Alexander I Gray, Susan Pyne   +2 more
exaly   +2 more sources

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation [PDF]

EMBO Journal, 2003
Copyright © 2003 European Molecular Biology OrganizationSphingosine kinase 1 is an agonist-activated signalling enzyme that catalyses the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in a number of agonist ...
Stuart M Pitson, Paul A B Moretti, Pu Xia   +2 more
exaly   +2 more sources