Results 131 to 140 of about 371,184 (271)

Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo

Scientific Reports, 2017
Sphingosine-1-phospate is a potent bioactive lipid metabolite that regulates cancer progression. Because sphingosine kinase 1 and sphingosine kinase 2 (SPHK 1/2) are both essential for sphingosine-1-phospate production, they could be a therapeutic target
Masaya Funaki, Juria Kitabayashi, Tetsuro Shimakami, N. Nagata, Yuriko Sakai, Kai Takegoshi, Hikari Okada, Kazuhisa Murai, Takayoshi Shirasaki, T. Oyama, T. Yamashita, Tsuguhito Ota, Y. Takuwa, M. Honda, S. Kaneko   +14 more
semanticscholar   +1 more source

Breaking Barriers: Characterization of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 678-687, March 2026.
Vascular leakage and its associated phenomena vasodilation and endothelial activation are pathophysiological features of various diseases. Multiple drug candidates targeting these phenomena are in development, necessitating translational models to demonstrate proof‐of‐pharmacology and proof‐of‐mechanism in early‐phase clinical trials.
Marella Cornelia Elizabeth van Ruissen, Menno van Diemen, Liza Botros, Ingrid Tomljanovic, Hind Achbo, Dimitra Eleftheriou, Paul Willem Schenk, Naomi Bertine Klarenbeek, Derek William Gilroy, Manon Aleida Adriana Jansen, Matthijs Moerland   +10 more
wiley   +1 more source

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants

International Journal of Molecular Sciences, 2017
In its soluble form, the extracellular matrix proteoglycan biglycan triggers the synthesis of the macrophage chemoattractants, chemokine (C-C motif) ligand CCL2 and CCL5 through selective utilization of Toll-like receptors (TLRs) and their adaptor ...
L. T. Hsieh, M. Nastase, Heiko Roedig, Jinyang Zeng-Brouwers, Chiara Poluzzi, S. Schwalm, Christian Fork, Claudia Tredup, R. Brandes, M. Wygrecka, A. Huwiler, J. Pfeilschifter, L. Schaefer   +12 more
semanticscholar   +1 more source

Internalization of Exogenous Myelin by Oligodendroglia Promotes Lineage Progression

Glia, Volume 74, Issue 3, March 2026.
Oligodendroglia internalize extracellular myelin debris in vitro and in vivo. Internalized myelin modulates lipid metabolism and lipid droplet formation. Myelin‐derived signals promote oligodendroglial proliferation and lineage progression. ABSTRACT Oligodendrocytes, traditionally recognized for their role in central nervous system myelination, have ...
Carla Peiró‐Moreno, Juan Carlos Chara, Katy Marshall‐Phelps, Irune Ugarte‐Arakistain, Stefano Calovi, Rafael Gois De Almeida, María Domercq, Carlos Matute   +7 more
wiley   +1 more source

Significance of sphingosine kinase 1 expression in feline mammary tumors

BMC Veterinary Research, 2019
Background Sphingosine kinase 1 (SPHK1) is an enzyme that converts pro-apoptotic ceramide and sphingosine into anti-apoptotic sphingosine-1-phosphate.
Yi-Chih Chang, Hsiao-Li Chuang, Ji-Hang Yin, Jiunn-Wang Liao, Ter-Hsin Chen, Yu-Chih Wang   +5 more
doaj   +1 more source

Combination of RAD001 (everolimus) and docetaxel reduces prostate and breast cancer cell VEGF production and tumour vascularisation independently of sphingosine-kinase-1 [PDF]

, 2017
Resistance to docetaxel is a key problem in current prostate and breast cancer management. We have recently discovered a new molecular mechanism of prostate cancer docetaxel chemoresistance mediated by the mammalian target of rapamycin (mTOR)/sphingosine-
A Datta, AT Oosterom van, B Malavaud, C Hwang, C Ortholan, D Bufalo Del, D Pchejetski, D Pchejetski, D Pchejetski, D Pchejetski, D Pchejetski, H Alshaker, H Alshaker, H Alshaker, H Alshaker, H Zhong, HL Goel, J Dancey, K Heo, L Sauer, M Guba, M Liu, M Nagahashi, MA Khan, N Kozakowski, R Bianco, RA Madan, RJ Motzer, S Murray, S Walsh, SM Pitson, T Weichhart, U Saran, X Zhang   +33 more
core   +1 more source

The role of cytokines in ovarian cancer drug resistance

International Journal of Cancer, Volume 158, Issue 4, Page 821-834, 15 February 2026.
Abstract Ovarian cancer is the leading cause of death among women diagnosed with female reproductive system cancers. While significant advances have been made in treating various types of cancer, progress in ovarian cancer treatment over the past 20 years has been minimal, and the treatment course of ovarian cancer is not linear. Although many patients
Lu Wang, Yunxia Zang, Rebeka Dejenie, Junyuan Bing, Shixia Dong, Yanfei Zhang, Yi Zhu, Jingjing Li   +7 more
wiley   +1 more source

Open field study of some Zea mays hybrids, lipid compounds and fumonisins accumulation [PDF]

, 2015
Lipid molecules are increasingly recognized as signals exchanged by organisms interacting in pathogenic and/or symbiotic ways. Some classes of lipids actively determine the fate of the interactions.
Battilani, Paola, Cirlini, Martin, Dall’Asta, Chiara, Fanelli, Corrado, Galaverna, Gianni, Giorni, Paola, Ludovici, Matteo, Reverberi, Massimo, Scala, Valeria   +8 more
core   +2 more sources

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Sphingosine kinase 1 as an anticancer therapeutic target

Drug Design, Development and Therapy, 2015
Ying Gao,1,* Fei Gao,2,* Kan Chen,3,* Mei-li Tian,1 Dong-li Zhao1 1Department of Radiotherapy Oncology, First Affiliated Hospital of Xi’an Jiaotong University, 2Department of Neurology, First Affiliated Hospital of Xi’an Medical University ...
Gao Y, Gao F, Chen K, Tian ML, Zhao DL
doaj