Results 1 to 10 of about 534,301 (305)
New Journal of Physics, 2018 Spindles are self-organized microtubule-based structures that segregate chromosomes during cell division. The mass of the spindle is controlled by the balance between microtubule turnover and nucleation. The mechanisms that control the spatial regulation
Bryan Kaye +5 more
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Three-dimensional structure of kinetochore-fibers in human mitotic spindles
eLife, 2022 During cell division, kinetochore microtubules (KMTs) provide a physical linkage between the chromosomes and the rest of the spindle. KMTs in mammalian cells are organized into bundles, so-called kinetochore-fibers (k-fibers), but the ultrastructure of ...
Robert Kiewisz +5 more
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Frontiers in Neurology, 2022 PurposeInterictal epileptic discharges (IEDs) are known to affect cognitive function in patients with epilepsy, but the mechanism has not been elucidated.
Toshiki Okadome +8 more
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Coupling between motor cortex and striatum increases during sleep over long-term skill learning
eLife, 2021 The strength of cortical connectivity to the striatum influences the balance between behavioral variability and stability. Learning to consistently produce a skilled action requires plasticity in corticostriatal connectivity associated with repeated ...
Stefan M Lemke +5 more
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eLife, 2022 During anaphase B, molecular motors slide interpolar microtubules to elongate the mitotic spindle, contributing to the separation of chromosomes. However, sliding of antiparallel microtubules reduces their overlap, which may lead to spindle breakage ...
Manuel Lera-Ramirez +2 more
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eLife, 2020 The spindle generates force to segregate chromosomes at cell division. In mammalian cells, kinetochore-fibers connect chromosomes to the spindle. The dynamic spindle anchors kinetochore-fibers in space and time to move chromosomes.
Pooja Suresh +2 more
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Frontiers in Cell and Developmental Biology, 2021 RBM14 is an RNA-binding protein that regulates spindle integrity in mitosis; however, its functions during meiosis are still unclear. In this study, we discovered that RBM14 expression was down-regulated in oocytes from old mice.
Hao Qin +20 more
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Loss of PDK1 Induces Meiotic Defects in Oocytes From Diabetic Mice
Frontiers in Cell and Developmental Biology, 2021 Maternal diabetes has been shown to impair oocyte quality; however, the underlying mechanisms remain unclear. Here, using a streptozotocin (STZ)-induced diabetic mouse model, we first detected and reduced expression of pyruvate dehydrogenase kinase 1 ...
Juan Ge +8 more
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Strong static magnetic field delayed the early development of zebrafish [PDF]
Open Biology, 2019 One of the major topics in magnetobiology is the biological effects of strong static magnetic field (SMF) on living organisms. However, there has been a paucity of the comprehensive study of the long-term effects of strong SMF on an animal's development.
Shuchao Ge +6 more
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A Role of PI3K/Akt Signaling in Oocyte Maturation and Early Embryo Development
Cells, 2023 A serine/threonine-specific protein kinase B (PKB), also known as Akt, is a key factor in the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway that regulates cell survival, metabolism and proliferation.
Jaroslav Kalous +2 more
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