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Spindle Starshaped Sets [PDF]

open access: yesAequationes mathematicae, 2014
In this paper, spindle starshaped sets are introduced and investigated, which apart from normalization form an everywhere dense subfamily within the family of starshaped sets. We focus on proving spindle starshaped analogues of recent theorems of Bobylev,
Bezdek, Karoly, Naszodi, Marton
core   +6 more sources

Human spindle variability [PDF]

open access: yesThe Journal of Neuroscience, 2021
AbstractIn humans, sleep spindles are 10-16 Hz oscillations lasting approximately 0.5-2 s. Spindles, along with cortical slow oscillations, facilitate memory consolidation by enabling synaptic plasticity. Early recordings of spindles at the scalp found anterior channels had overall slower frequency than central-posterior channels.
Christopher Gonzalez   +3 more
openaire   +4 more sources

Multiple motors cooperate to establish and maintain acentrosomal spindle bipolarity in C. elegans oocyte meiosis

open access: yeseLife, 2022
While centrosomes organize spindle poles during mitosis, oocyte meiosis can occur in their absence. Spindles in human oocytes frequently fail to maintain bipolarity and consequently undergo chromosome segregation errors, making it important to understand
Gabriel Cavin-Meza   +2 more
doaj   +1 more source

CtIP Regulates Mitotic Spindle Assembly by Modulating the TPX2-Aurora A Signaling Axis

open access: yesCells, 2022
CtBP-interacting protein (CtIP) plays a critical role in controlling the homologous recombination-mediated DNA double-stranded break (DSB) repair pathway through DNA end resection, and recent studies suggest that it also plays a role in mitosis. However,
Wonkyung Oh   +4 more
doaj   +1 more source

Sleep spindles [PDF]

open access: yesCurrent Biology, 2018
Schönauer and Pöhlchen introduce the reader to sleep spindles, brain oscillations that occur during nREM sleep that are thought to function in the stabilization of memories.
Schönauer, Monika, Pöhlchen, Dorothee
openaire   +3 more sources

Orderly assembly underpinning built-in asymmetry in the yeast centrosome duplication cycle requires cyclin-dependent kinase

open access: yeseLife, 2020
Asymmetric astral microtubule organization drives the polarized orientation of the S. cerevisiae mitotic spindle and primes the invariant inheritance of the old spindle pole body (SPB, the yeast centrosome) by the bud.
Marco Geymonat   +6 more
doaj   +1 more source

The evolutionary history of human spindle genes includes back-and-forth gene flow with Neandertals

open access: yeseLife, 2022
Proteins associated with the spindle apparatus, a cytoskeletal structure that ensures the proper segregation of chromosomes during cell division, experienced an unusual number of amino acid substitutions in modern humans after the split from the ...
Stéphane Peyrégne   +3 more
doaj   +1 more source

Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle

open access: yeseLife, 2022
During cell division, the spindle generates force to move chromosomes. In mammals, microtubule bundles called kinetochore-fibers (k-fibers) attach to and segregate chromosomes. To do so, k-fibers must be robustly anchored to the dynamic spindle.
Pooja Suresh   +3 more
doaj   +1 more source

Excess TPX2 Interferes with Microtubule Disassembly and Nuclei Reformation at Mitotic Exit

open access: yesCells, 2020
The microtubule-associated protein TPX2 is a key mitotic regulator that contributes through distinct pathways to spindle assembly. A well-characterised function of TPX2 is the activation, stabilisation and spindle localisation of the Aurora-A kinase ...
Francesco D. Naso   +9 more
doaj   +1 more source

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