A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells. [PDF]
, 2014 Dynamic instability, polarity, and spatiotemporal organization are hallmarks of the microtubule cytoskeleton that allow formation of complex structures such as the eukaryotic spindle. No similar structure has been identified in prokaryotes.
Agard, David A +6 more
core +2 more sources
DSK1, a novel kinesin-related protein from the diatom Cylindrotheca fusiformis that is involved in anaphase spindle elongation. [PDF]
, 1996 We have identified an 80-kD protein that is involved in mitotic spindle elongation in the diatom Cylindrotheca fusiformis. DSK1 (Diatom Spindle Kinesin 1) was isolated using a peptide antibody raised against a conserved region in the motor domain of the ...
Brady, B +3 more
core +2 more sources
iScience, 2021 Summary: Here we identify human Kinesin-5, Kif11/HsEg5, as a cellular target of Zika protease. We show that Zika NS2B-NS3 protease targets several sites within the motor domain of HsEg5 irrespective of motor binding to microtubules.
Liqiong Liu +3 more
doaj +1 more source
The novel BTB-kelch protein, KBTBD8, is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis [PDF]
Cell Division, 2013 Abstract Proteins of the BTB-kelch family are known to be involved in multiple biological processes such as migration, cytoskeleton arrangement, regulation of cell morphology, protein ubiquitination and gene expression. KBTBD8 is a new member of this family.
Luehrig, Sandra +3 more
openaire +4 more sources
Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes. [PDF]
PLoS ONE, 2011 Mammalian oocyte meiotic maturation involves oocyte polarization and a unique asymmetric division, but until now, the underlying mechanisms have been poorly understood.
Shao-Chen Sun +5 more
doaj +1 more source
Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium
Cells, 2021 Aberrant centrosome activities in mutants of Dictyostelium discoideum result in anomalies of mitotic spindles that affect the reliability of chromosome segregation.
Mary Ecke +2 more
doaj +1 more source
Segregation of a microsporidian parasite during host cell mitosis [PDF]
, 1999 We investigated the segregation of an intracellular microsporidian parasite during host cell division. A time-course experiment was carried out to examine the distribution of parasites relative to host chromosomal DNA via light and electron microscopy.
Dunn, A.M., Smith, J.E., Terry, R.S.
core +1 more source
Exotic mitotic mechanisms [PDF]
, 2012 The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope.
Drechsler, Hauke, McAinsh, Andrew D.
core +1 more source
Ubiquitin in regulation of spindle apparatus and its positioning: implications in development and disease [PDF]
Biochemistry and Cell Biology, 2015 Emerging data implicates ubiquitination, a post-translational modification, in regulating essential cellular events, one of them being mitosis. In this review we discuss how various E3 ligases modulate the cortical proteins such as dynein, LGN, NuMa, Gα, along with polymerization, stability, and integrity of spindles.
Srivastava, Devika, Chakrabarti, Oishee
openaire +3 more sources
Natural products as new antimitotic compounds for anticancer drug development
Clinics, 2018 Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness.
Carlos Roberto Koscky Paier +8 more
doaj +1 more source