Results 61 to 70 of about 995,356 (273)

A nuclear-derived proteinaceous matrix embeds the microtubule spindle apparatus during mitosis

Molecular Biology of the Cell, 2012
A live-imaging approach is used to demonstrate that nuclear proteins reorganize during mitosis to form a highly dynamic, viscous spindle matrix that embeds the microtubule spindle apparatus, stretching from pole to pole.
Changfu Yao, Uttama Rath, H. Maiato, D. Sharp, J. Girton, K. Johansen, J. Johansen   +6 more
semanticscholar   +1 more source

Natural products as new antimitotic compounds for anticancer drug development

Clinics, 2018
Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness.
Carlos Roberto Koscky Paier, Sarah Sant’Anna Maranhão, Teiliane Rodrigues Carneiro, Lídia Moreira Lima, Danilo Damasceno Rocha, Renan da Silva Santos, Kaio Moraes de Farias, Manoel Odorico de Moraes-Filho, Claudia Pessoa   +8 more
doaj   +1 more source

Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes. [PDF]

PLoS ONE, 2011
Mammalian oocyte meiotic maturation involves oocyte polarization and a unique asymmetric division, but until now, the underlying mechanisms have been poorly understood.
Shao-Chen Sun, Zhen-Bo Wang, Yong-Nan Xu, Seung-Eun Lee, Xiang-Shun Cui, Nam-Hyung Kim   +5 more
doaj   +1 more source

Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium

Cells, 2021
Aberrant centrosome activities in mutants of Dictyostelium discoideum result in anomalies of mitotic spindles that affect the reliability of chromosome segregation.
Mary Ecke, Jana Prassler, Günther Gerisch   +2 more
doaj   +1 more source

Fig-S3 from Mitotic Spindle Apparatus Abnormalities in Chronic Obstructive Pulmonary Disease Cells: A Potential Pathway to Lung Cancer [PDF]

, 2023
Jose Thaiparambil, Lingyun Dong, Diana Jasso, Jian‐An Huang, Randa El‐Zein   +4 more
openalex   +2 more sources

Establishment and mitotic characterization of new Drosophila acentriolar cell lines from DSas-4 mutant

Biology Open, 2013
Summary In animal cells the centrosome is commonly viewed as the main cellular structure driving microtubule (MT) assembly into the mitotic spindle apparatus.
Nicolas Lecland, Alain Debec, Audrey Delmas, Sara Moutinho-Pereira, Nicolas Malmanche, Anais Bouissou, Clémence Dupré, Aimie Jourdan, Brigitte Raynaud-Messina, Helder Maiato, Antoine Guichet   +10 more
doaj   +1 more source

Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation.

PLoS ONE, 2018
In Drosophila it has recently been demonstrated that a spindle matrix in the form of a membrane-less macromolecular assembly embeds the microtubule-based spindle apparatus.
Changfu Yao, Chao Wang, Yeran Li, Michael Zavortink, Vincent Archambault, Jack Girton, Kristen M Johansen, Jørgen Johansen   +7 more
doaj   +1 more source

Mechanism of spindle pole organization and instability in human oocytes

Science, 2022
Human oocytes are prone to assembling meiotic spindles with unstable poles, which can favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown.
C. So, Katerina Menelaou, Julia Uraji, Katarina Harasimov, A. Steyer, K. B. Seres, J. Bucevičius, G. Lukinavičius, W. Möbius, Claus Sibold, A. Tandler-Schneider, H. Eckel, Rüdiger Moltrecht, M. Blayney, K. Elder, M. Schuh   +15 more
semanticscholar   +1 more source

From Spin to Star: Ultrafast Dual‐Gradient Centrifugal Microfluidics for Scalable High‐Throughput and Combinatorial Nanomaterial Synthesis

Advanced Functional Materials, EarlyView.
A dual‐gradient centrifugal microfluidic platform enables ultrafast, high‐throughput screening of nanomaterials in 90 reaction chambers. Through siphon‐based aliquoting and automated gradient generation, the system achieves combinatorial synthesis of silver nanoparticles with diverse morphologies.
Hiep Van Nguyen, Vu Minh Phan, Tae Seok Seo   +2 more
wiley   +1 more source

A Human Neural Tube Model Using 4D Self‐Folding Smart Scaffolds

Advanced Healthcare Materials, EarlyView.
Induced pluripotent stem cells (iPSCs) exhibit features comparable to the inner cell mass of the human embryo. iPSCs are applied to a novel self‐folding 4D‐Neural Tube (4D‐NT) structure that mimics the neurulation process. This 4D‐NT model recapitulates early events of human neural development and represents a platform to explore neurodevelopmental ...
Claudia Dell'Amico, Irene Chiesa, Angela Toffano, Alessio Esposito, Piera Mancini, Chiara Magliaro, Angeliki Louvi, Carmelo De Maria, Marco Onorati   +8 more
wiley   +1 more source