Ubiquitin in regulation of spindle apparatus and its positioning: implications in development and disease [PDF]
Biochemistry and Cell Biology, 2015 Emerging data implicates ubiquitination, a post-translational modification, in regulating essential cellular events, one of them being mitosis. In this review we discuss how various E3 ligases modulate the cortical proteins such as dynein, LGN, NuMa, Gα, along with polymerization, stability, and integrity of spindles.
Srivastava, Devika, Chakrabarti, Oishee
openaire +3 more sources
A comparison of the distribution of actin and tubulin in the mammalian mitotic spindle as seen by indirect immunofluorescence [PDF]
, 1977 Rabbit antibodies against actin and tubulin were used in an indirect immunofluorescence study of the structure of the mitotic spindle of PtK1 cells after lysis under conditions that preserve anaphase chromosome movement. During early prophase there is no
Cande, W. Zacheus +2 more
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Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation.
PLoS ONE, 2018 In Drosophila it has recently been demonstrated that a spindle matrix in the form of a membrane-less macromolecular assembly embeds the microtubule-based spindle apparatus.
Changfu Yao +7 more
doaj +1 more source
A Mathematical Framework for Kinetochore-Driven Activation Feedback in the Mitotic Checkpoint [PDF]
, 2017 Proliferating cells properly divide into their daughter cells through a process that is mediated by kinetochores, protein-complexes that assemble at the centromere of each sister chromatid. Each kinetochore has to establish a tight bipolar attachment to the spindle apparatus before sister-chromatid separation is initiated.
arxiv +1 more source
Long-Range Repulsion Between Chromosomes in Mammalian Oocyte Spindles [PDF]
arXiv, 2022 During eukaryotic cell division, a microtubule-based structure called the spindle exerts forces on chromosomes, thereby organizing and segregating them Extensive work demonstrates that the forces acting parallel to the spindle axis, including those responsible for separating sister chromatids, are generated by microtubule polymerization and ...
arxiv
Illuminating spindle convex bodies and minimizing the volume of spherical sets of constant width [PDF]
Discrete and Computational Geometry 47/2 (2012), 275-287, 2011 A subset of the d-dimensional Euclidean space having nonempty interior is called a spindle convex body if it is the intersection of (finitely or infinitely many) congruent d-dimensional closed balls. The spindle convex body is called a "fat" one, if it contains the centers of its generating balls.
arxiv +1 more source
Perturbing Microtubule Integrity Blocks AMP-Activated Protein Kinase-Induced Meiotic Resumption in Cultured Mouse Oocytes [PDF]
, 2012 The oocyte meiotic spindle is comprised of microtubules (MT) that bind chromatin and regulate both metaphase plate formation and karyokinesis during meiotic maturation; however, little information is known about their role in meiosis reinitiation.
Downs, Stephen, Ya, Ru
core +2 more sources
Spindle configurations of skew lines [PDF]
Geom. Topol. 11 (2007) 1049-1081, 2002 We prove a conjecture of Crapo and Penne which characterizes isotopy classes of skew configurations with spindle-structure. We use this result in order to define an invariant, spindle-genus, for spindle-configurations. We also slightly simplify the exposition of some known invariants for configurations of skew lines and use them to define a natural ...
arxiv +1 more source
Microtubule organization within mitotic spindles revealed by serial block face scanning electron microscopy and image analysis [PDF]
, 2017 Serial block face scanning electron microscopy (SBF-SEM) is a powerful method to analyze cells in 3D. Here, working at the resolution limit of the method, we describe a correlative light-SBF-SEM workflow to resolve microtubules of the mitotic spindle in ...
Beckett, AJ +8 more
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Frontiers in Plant ScienceThe significance of heat stress in agriculture is ever-increasing with the progress of global climate changes. Due to a negative effect on the yield of staple crops, including wheat, the impairment of plant reproductive development triggered by high ...
Attila Fábián +6 more
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