Results 111 to 120 of about 51,274 (213)

Directed Evolution Improves the Catalytic Efficiency of APEX2‐Mediated Proximity‐Dependent RNA Labeling

Advanced Science, Volume 13, Issue 32, 9 June 2026.
ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley   +1 more source

GATAD2B regulates spindle assembly by affecting protein deacetylation during oocyte meiotic maturation. [PDF]

Anim Biosci
Xu Q, Yu L, Lin Y, Guo A, Zhang Y, Zhang Z, Yan G, Sun H, Cao G.   +8 more
europepmc   +1 more source

Quantum Dots for Biomedical Biosensing, NIR‐II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This review outlines bottom‐up and biomimetic fabrication strategies of quantum dots, and highlights their emerging applications in biosensing, multimodal bioimaging, and intelligent cancer theranostics. It further discusses key translational barriers and future perspectives for advancing QD‐based nanomedicine toward clinical implementation.
Jie Ju, Zhifang Liu, Xinran Gao, Wen Sun, Wei Fu, Yanfei Wang   +5 more
wiley   +1 more source

Role of spindle assembly checkpoint proteins in gametogenesis and embryogenesis. [PDF]

Front Cell Dev Biol
Pun R, North BJ.
europepmc   +1 more source

Wave Mechanics of Ciliary Proteins: Quantum‐Enabled Sensing and Energy Transfer in the “Cellular Antenna”

Aggregate, Volume 7, Issue 6, June 2026.
This review surveys eukaryotic cilia as putative quantum‐enabled sensory and regulatory centers. It highlights their multifaceted roles in the cell, focuses on the nontrivial roles of quantum mechanics in their membrane and cytoskeletal proteins, and introduces the essential building blocks enabling quantum properties to survive in the warm, wet, and ...
Daniel L. Bilezikian, Dylan Davidoff, Justin R. Caram, Thomas P. Fay, Aarat P. Kalra, Paul S. Weiss   +5 more
wiley   +1 more source

C. elegans SSNA-1 is required for the structural integrity of centrioles and bipolar spindle assembly. [PDF]

Nat Commun
Pfister JA, Agostini L, Bournonville L, Perrier A, Sankaralingam P, Bell ZG, Hamel V, Guichard P, Biertümpfel C, Mizuno N, O'Connell KF.   +10 more
europepmc   +1 more source

The E3 ubiquitin ligase SPRYD3-MYCBP2(PAM) regulates mitotic cell fate and ubiquitination of USP11 to control spindle assembly. [PDF]

J Biol Chem
Turi da Fonte Dias AR, Hoffmann I.
europepmc   +1 more source

AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation. [PDF]

Life Sci Alliance
Blengini CS, Tang S, Mendola RJ, Garrisi GJ, Swain JE, Schindler K.   +5 more
europepmc   +1 more source

Kv7 and K2P Potassium Channels in Thalamocortical Function and Their Therapeutic Potential in Childhood Absence Epilepsy

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Modulation of K2P and Kv7 channels has the potential to reduce hyperexcitability and hypersynchronicity within the thalamocortical system. This offers a new avenue to suppress spike and wave discharges, the electrophysiological hallmark of absence epilepsy.
Anushka Takhi, Guiscard Seebohm, Thomas Budde, Annika Lüttjohann   +3 more
wiley   +1 more source

MoMad2 With a Conserved Function in the Spindle Assembly Checkpoint Is Required for Maintaining Appressorial Turgor Pressure and Pathogenicity of Rice Blast Fungus. [PDF]

Mol Plant Pathol
Shen T, Chen Q, Leontiou I, Wang R, Su M, Luo Q, Lu G, Wang Z, Li Y, Hardwick KG, Wang M.   +10 more
europepmc   +1 more source