Results 131 to 140 of about 58,631 (285)

SnapShot: Nonmotor Proteins in Spindle Assembly

Cell, 2008
Chromosome segregation during cell division depends on the highly ordered bipolar microtubule structure known as the mitotic spindle. Organization of microtubules into this highly ordered structure relies on both motor and nonmotor proteins. Nonmotor spindle proteins fulfill diverse roles including nucleation and organization of microtubules ...
Manning, Amity L., Compton, Duane A.
openaire   +2 more sources

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation [PDF]

, 2015
The interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved.
Cristina Gutiérrez-Caballero, Stephen J. Royle, Royle, Stephen J., Bayliss, Richard, Stephen J. Royle (4352794), Burgess, Selena G., C. Gutiérrez-Caballero (7673825), Selena G. Burgess (764360), Gutierrez-Caballero, Cristina, Selena G. Burgess, Richard Bayliss, Richard Bayliss (610319)   +11 more
core   +1 more source

Towards Advanced Intelligent and Perceptive Soft Grippers

Advanced Intelligent Systems, EarlyView.
Implementing soft yet strong and intelligent soft grippers request innovative and creative solutions in designing soft bodies and seamlessly integrating actuated systems with hierarchical sensing. This review systematically analyses soft grippers with a deep understanding of core components, from fundamental design principles to actuation and sensing ...
Haneul Kim, Hayeon Shin, Seik Park, Changbeom Shim, Seonggun Joe   +4 more
wiley   +1 more source

Mitotic centromere-associated kinesin (MCAK) : a potential cancer drug target [PDF]

, 2011
The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability.
Yuan, Juping, Louwen, Frank, Sanhaji, Mourad, Friel, Claire T., Wordeman, Linda   +4 more
core   +2 more sources

Compliant hydrogel cuff coating with real‐time pressure monitoring and antibiofilm capabilities for ventilator‐associated pneumonia prophylaxis

BMEMat, EarlyView.
A soft‐compliant hydrogel cuff coating combines real‐time pressure monitoring with intrinsic antibacterial activity for prophylaxis of ventilator‐associated pneumonia. A flexible pressure‐sensing patch is embedded in the coating to enable wireless dynamic monitoring of endotracheal cuff pressure through Bluetooth.
Jin Chai, Yifu Tan, Jiaheng Liang, Shen Liu, Jiabin Zhao, Shanbo Ma, Chunxin Liu, Minghua Du, Mark Selvan, Xiaopeng Shi, Liqiang Song, Peng Li   +11 more
wiley   +1 more source

Spindle Assembly: More Than Just Microtubules [PDF]

, 2010
SummaryDo actin dynamics play an active role in mitotic spindle assembly? A new study demonstrates that cortical actin polymerization assists with the earliest phase of spindle pole ...
Rogers, Gregory C.
core   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Regulation der humanen Aurora-A Kinase und Identifikation potentieller Interaktionspartner [PDF]

, 2004
The error-free segregation of duplicated chromosomes during cell division is essential for the maintenance of an intact genome. This process is brought about by a highly dynamic bipolar array of microtubules, the mitotic spindle.
Kufer, Thomas
core  

Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment [PDF]

, 2010
Transforming acidic coiled-coil-containing protein 3 (TACC3) has been implicated in mitotic spindle assembly, although the mechanisms involved are largely unknown.
Tao, Wei, Jiang, Qing, Paul R. Clarke, Minglei Bian, Fu, Wenxiang, Zhang, Chuanmao, Zheng, Puwei, Fu, Jingyan, Wei Tao, Jingyan Fu, Puwei Zheng, Qing Jiang, Chuanmao Zhang, Bian, Minglei, Clarke, Paul R., Wenxiang Fu   +15 more
core   +1 more source