Results 71 to 80 of about 17,463 (177)

Cellular response upon proliferation in the presence of an active mitotic checkpoint

Life Science Alliance, 2019
Cells that replicate with an active mitotic checkpoint remain capable to mount multiple times an efficient arrest, are bigger than unperturbed cells, rely more heavily on Cdh1, and have an altered protein expression profile. Eukaryotic cells treated with
Andrea Corno, Elena Chiroli, Fridolin Gross, Claudio Vernieri, Vittoria Matafora, Stefano Maffini, Marco Cosentino Lagomarsino, Angela Bachi, Andrea Ciliberto   +8 more
doaj   +1 more source

Biomimetic Iridium‐Based Photothermal Nanozyme to Trigger Ferroptosis and Pyroptosis and Activate the cGAS‐STING Pathway for Improved Tumor Immunotherapy

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study develops an iridium‐based nanozyme (IIN@M) with superior enzyme‐like activity and photothermal performance. It disrupts intracellular redox balance by generating reactive oxygen species and depleting glutathione, which synergistically induces ferroptosis, pyroptosis, and immunogenic cell death.
Lijun Ding, Zhongxiong Fan, Guoyu Xia, Fukai Zhu, Nan Yang, Shujie Yu, Longlong Yuan, Jinyao Li   +7 more
wiley   +1 more source

Establishment and mitotic characterization of new Drosophila acentriolar cell lines from DSas-4 mutant

Biology Open, 2013
Summary In animal cells the centrosome is commonly viewed as the main cellular structure driving microtubule (MT) assembly into the mitotic spindle apparatus.
Nicolas Lecland, Alain Debec, Audrey Delmas, Sara Moutinho-Pereira, Nicolas Malmanche, Anais Bouissou, Clémence Dupré, Aimie Jourdan, Brigitte Raynaud-Messina, Helder Maiato, Antoine Guichet   +10 more
doaj   +1 more source

Co‐Treatment With rhBMP‐2 and Rapamycin Modulates Osteogenesis–Adipogenesis Balance to Enhance Aged Bone Regeneration

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study demonstrates that the imbalance between osteogenic and adipogenic differentiation in senescent BMSCs, leading to excessive adipocyte accumulation, which subsequently impairs bone regeneration in aged mice. To address this pathological dysregulation, a novel energy‐supplying hydrogel system (PBR) has been developed to restore balanced ...
Zirui He, Xiaoqiao Bai, Fangru Xie, Xuan Wang, Fan Zhang, Yuanman Yu, Yuan Yuan, Changsheng Liu   +7 more
wiley   +1 more source

Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C

Nature Communications, 2019
During the spindle assembly checkpoint, the activity of the anaphase promoting complex/cyclosome (APC/C) is repressed, yet cyclin A2 evades the checkpoint and is targeted for degradation.
Suyang Zhang, Thomas Tischer, David Barford   +2 more
doaj   +1 more source

Morphogen Gradients as Drivers of Mosaicism During Early Human Development

BioEssays, Volume 48, Issue 3, March 2026.
We hypothesise that the antero‐posterior (A–P) signalling gradients created by the embryonic and extraembryonic interface during human gastrulation generate overlapping patterns of genomic mosaicism, with possible links to embryonic lethality and lineage‐specific developmental disorders.
Sergio P. Acebrón, Janina Hattemer, Tobias Rausch, Anchel De Jaime‐Soguero   +3 more
wiley   +1 more source

A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling

eLife, 2017
The master spindle checkpoint kinase Mps1 senses kinetochore-microtubule attachment and promotes checkpoint signaling to ensure accurate chromosome segregation.
Zhejian Ji, Haishan Gao, Luying Jia, Bing Li, Hongtao Yu   +4 more
doaj   +1 more source

Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis

Cell Division, 2009
The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications.
Moore Finola E, Ray Dipankar, Osmundson Evan C, Kiyokawa Hiroaki   +3 more
doaj   +1 more source

Centriole assembly and the role of Mps1: defensible or dispensable?

Cell Division, 2011
The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C.
Fisk Harold A, Pike Amanda N
doaj   +1 more source

Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex

Nature Communications
The spindle assembly checkpoint (SAC) ensures mitotic exit occurs only after sister chromatid biorientation, but how this coordination is mechanistically achieved remains unclear.
Suruchi Sethi, Sabrina Ghetti, Verena Cmentowski, Teresa Benedetta Guerriere, Patricia Stege, Valentina Piano, Andrea Musacchio   +6 more
doaj   +1 more source