Results 71 to 80 of about 50,149 (285)
The Spindle Assembly Checkpoint: Clock or Domino?
, 2011 In each cell division, the newly duplicated chromosomes must be evenly distributed between the sister cells. Errors in this process during meiosis or mitosis are equally fatal: improper segregation of the chromosome 21 during human meiosis leads to Down syndrome (Conley, Aneuploidy: etiology and mechanisms, pp 35-89, 1985), whereas in somatic cells ...
de Medina-Redondo Maria, Meraldi Patrick
openaire +4 more sources
The RZZ Complex and the Spindle Assembly Checkpoint
Cell Structure and Function, 2009 The conserved protein Rod is found in various organisms. It is localized on the kinetochores or spindle microtubules during cell division. Rod is required for proper chromosome segregation during both mitosis and meiosis. The effects of rod mutations are similar for both equational and reductional divisions, giving rise to anaphases with lagging ...
Heng Liu +4 more
openaire +4 more sources
Kinetochore stretching inactivates the spindle assembly checkpoint [PDF]
Journal of Cell Biology, 2009 The spindle assembly checkpoint (SAC) monitors the attachment of microtubules to the kinetochore and inhibits anaphase when microtubule binding is incomplete. The SAC might also respond to tension; however, how cells can sense tension and whether its detection is important to satisfy the SAC remain controversial.
Tetsuo Noda +5 more
openaire +3 more sources
Biology Open, 2019 The spindle assembly checkpoint (SAC) prevents erroneous chromosome segregation by delaying mitotic progression when chromosomes are incorrectly attached to the mitotic spindle.
Lydia R. Heasley +2 more
doaj +1 more source
Checkpointing SPAdes for Metagenome Assembly: Transparency versus Performance in Production [PDF]
arXiv, 2021 The SPAdes assembler for metagenome assembly is a long-running application commonly used at the NERSC supercomputing site. However, NERSC, like many other sites, has a 48-hour limit on resource allocations. The solution is to chain together multiple resource allocations in a single run, using checkpoint-restart.
arxiv
Spindles and active vortices in a model of confined filament-motor mixtures [PDF]
BMC Biophysics 4, 18 (2011), 2011 Robust self-organization of subcellular structures is a key principle governing the dynamics and evolution of cellular life. In fission yeast cells undergoing division, the mitotic spindle spontaneously emerges from the interaction of microtubules, motor proteins and the confining cell walls, and asters and vortices have been observed to self-assemble ...
arxiv +1 more source
Front. Cell Dev. Biol., 2019 Targeting the mitotic pathways of rapidly proliferating tumor cells has been an effective strategy in traditional cancer therapy. Chemotherapeutics such as taxanes and vinca alkaloids, which disrupt microtubule function, have enjoyed clinical success ...
Weimei Ruan, Hong-Hwa Lim, U. Surana
semanticscholar +1 more source
FEBS Open Bio, EarlyView.We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang +9 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2017 Relatively little is known about the cross-talk between the spindle assembly checkpoint and the DNA damage response, especially in multicellular organisms.
Simone Bertolini +4 more
doaj +1 more source
A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect. [PDF]
PLoS ONE, 2012 The spindle assembly checkpoint is crucial for the maintenance of a stable chromosome number. Defects in the checkpoint lead to Chromosomal INstability (CIN), which is linked to the progression of tumors with poor clinical outcomes such as drug ...
Zeeshan Shaukat +4 more
doaj +1 more source