Results 71 to 80 of about 303,580 (303)
Journal of Biological Chemistry, 2015 Background: Oncoprotein YAP regulates cell proliferation and tumorigenesis, and a cellular function of YAP in mitosis is largely unknown. Results: YAP and its mitotic phosphorylation regulate the spindle checkpoint through up-regulation of BubR1 ...
Shuping Yang +4 more
semanticscholar +1 more source
The spindle checkpoint, aneuploidy, and cancer [PDF]
Oncogene, 2004 Cancer cells contain abnormal number of chromosomes (aneuploidy), which is a prevalent form of genetic instability in human cancers. Defects in a cell cycle surveillance mechanism called the spindle checkpoint contribute to chromosome instability and aneuploidy.
Rajnish, Bharadwaj, Hongtao, Yu
openaire +2 more sources
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
Multiple Duties for Spindle Assembly Checkpoint Kinases in Meiosis
Front. Cell Dev. Biol., 2017 Cell division in mitosis and meiosis is governed by evolutionary highly conserved protein kinases and phosphatases, controlling the timely execution of key events such as nuclear envelope breakdown, spindle assembly, chromosome attachment to the spindle ...
A. Marston, Katja Wassmann
semanticscholar +1 more source
The spindle assembly checkpoint and speciation
PeerJ, 2020 A mechanism is proposed by which speciation may occur without the need to postulate geographical isolation of the diverging populations. Closely related species that occupy overlapping or adjacent ecological niches often have an almost identical genome but differ by chromosomal rearrangements that result in reproductive isolation.
Jackson, Robert C, Mistry, Hitesh B
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Advanced Healthcare Materials, EarlyView.Novel photo‐clickable triazine‐trione thermosets can be shaped and cured under mild conditions, including room and physiological temperatures. These materials are biocompatible and support osteogenic differentiation of bone marrow–derived mesenchymal stem cells on their surface.
Åshild Johansen +7 more
wiley +1 more source
Journal of Cell Biology, 2015 During mitosis in human cells, separate mechanisms involving Aurora B and CENP-T promote anchoring of the microtubule- and checkpoint-receptor complex KMN at kinetochores.
Soonjoung Kim, Hongtao Yu
semanticscholar +1 more source
Mitosis: Short-Circuiting Spindle Checkpoint Signaling [PDF]
Current Biology, 2012 The spindle checkpoint forms an intricate signaling circuit to sense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset. Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint ...
Luo, Xuelian, Yu, Hongtao
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Advanced Science, EarlyView.YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang +8 more
wiley +1 more source
TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching
eLife, 2015 The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family.
Qiaozhen Ye +5 more
doaj +1 more source