Results 81 to 90 of about 4,116 (226)
Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint. [PDF]
PLoS ONE, 2007 Mitotic progression is controlled by proteolytic destruction of securin and cyclin. The mitotic E3 ubiquitin ligase, known as the anaphase promoting complex or cyclosome (APC/C), in partnership with its activators Cdc20p and Cdh1p, targets these proteins
Emma M J King +2 more
doaj +1 more source
Frontiers in Physiology, 2021 Mitosis proceeds through a defined series of events that is largely conserved, but the amount of time needed for their completion can vary in different cells and organisms.
Mathew Bloomfield +2 more
doaj +1 more source
The spindle checkpoint’s on-off switch [PDF]
Journal of Cell Biology, 2014 ![Figure][1] Mad1 (green) localizes to the kinetochores of control cells treated with nocodazole (left) but is absent from the kinetochores of cells that lack both CENP-I and Aurora B activity (right).
openaire +2 more sources
Spindle assembly checkpoint, aneuploidy and tumorigenesis [PDF]
Cell Cycle, 2009 Faithfully distributing chromosomes into two daughter cells in mitosis is essential for the maintenance of the integrity of the genome genome. The fidelity is achieved through a number of cellular processes among which is the spindle assembly checkpoint (SAC), an elaborate molecular pathway that monitors the attachment of microtubules to kinetochores ...
Min Li, Pumin Zhang
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The Hypoxia‐Associated High‐Risk Cell Subpopulation Distinctly Enhances the Progression of Glioma
Advanced Science, EarlyView.This study suggests the potential roles of a novel hypoxia‐associated CDC20+KIF20A+PTTG1+ cell subpopulation in glioma progression. This high‐risk glioma cell subpopulation is therapeutically vulnerable to glioma progression and may play important roles in glioma standard‐of‐care therapeutic resistance.
Quan Wan +13 more
wiley +1 more source
Advanced Science, EarlyView.Pancreatic cancer is a highly aggressive malignancy with limited treatment options. CLK4 regulates alternative splicing, contributing to cancer progression. This study establishes a computational model to identify CLK4 inhibitors, leading to compound 150441 (IC50: 21.4 nm).
Chun‐Lin Yang +13 more
wiley +1 more source
Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay
Nature Communications, 2017 The spindle assembly checkpoint delays mitotic progression until sister chromatids are bi-oriented. Here the authors show that moderate delays in mitotic progression induce centrosome fragmentation and centriole disengagement and that spindle bipolarity ...
Menuka Karki +2 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2008 CHFR is an E3 ubiquitin ligase and an early mitotic checkpoint protein implicated in many cancers and in the maintenance of genomic stability. To analyze the role of CHFR in genomic stability, by siRNA, we decreased its expression in genomically stable ...
Lisa M. Privette +4 more
doaj +1 more source
A novel role for the GTPase-activating protein Bud2 in the spindle position checkpoint. [PDF]
PLoS ONE, 2012 The spindle position checkpoint (SPC) ensures correct mitotic spindle position before allowing mitotic exit in the budding yeast Saccharomyces cerevisiae. In a candidate screen for checkpoint genes, we identified bud2Δ as deficient for the SPC. Bud2 is a
Scott A Nelson +3 more
doaj +1 more source
CDK5RAP2 is required for spindle checkpoint function [PDF]
Cell Cycle, 2009 The combination of paclitaxel and doxorubicin is among the most successful chemotherapy regimens in cancer treatment. CDK5RAP2, when mutated, causes primary microcephaly. We show here that inhibition of CDK5RAP2 expression causes chromosome mis-segregation, fails to maintain the spindle checkpoint, and is associated with reduced expression of the ...
Bo Wang +10 more
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