Role of spindle pole body component 25 in neurodegeneration. [PDF]
Ann Transl Med, 2021 Background Aberrant growth and polarization of microglia are critical for pathological initiation and progression of neurodegenerative conditions like Alzheimer’s disease (AD).
Cui F, Xu Z, Lv Y, Hu J.
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Novel phosphorylation states of the yeast spindle pole body. [PDF]
Biol Open, 2018 Phosphorylation regulates yeast spindle pole body (SPB) duplication and separation and likely regulates microtubule nucleation. We report a phosphoproteomic analysis using tandem mass spectrometry of enriched Saccharomyces cerevisiae SPBs for two cell ...
Fong KK +7 more
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The molecular architecture of the yeast spindle pole body core determined by Bayesian integrative modeling. [PDF]
Mol Biol Cell, 2017 A model of the core of the yeast spindle pole body (SPB) was created by a Bayesian modeling approach that integrated a diverse data set of biophysical, biochemical, and genetic information.
Viswanath S +16 more
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Knockdown of spindle pole body component 25 homolog inhibits cell proliferation and cycle progression in prostate cancer. [PDF]
Oncol Lett, 2018 Prostate cancer (PCa) is the most frequently diagnosed type of cancer in Chinese males. Cell-cycle aberration is a hallmark of cancer. Spindle pole body component 25 homolog (SPC25), a component of the Ndc80 complex, serves an important role in ...
Cui F, Hu J, Fan Y, Tan J, Tang H.
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Sec66-Dependent Regulation of Yeast Spindle-Pole Body Duplication Through Pom152. [PDF]
Genetics, 2015 In closed mitotic systems such as Saccharomyces cerevisiae, the nuclear envelope (NE) does not break down during mitosis, so microtubule-organizing centers such as the spindle-pole body (SPB) must be inserted into the NE to facilitate bipolar spindle ...
Katta SS +8 more
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The N-terminus of Sfi1 and yeast centrin Cdc31 provide the assembly site for a new spindle pole body. [PDF]
J Cell Biol, 2021 Rüthnick et al. decipher how the assembly of the daughter spindle pole body (dSPB) works on a molecular level. Recruitment of the proteins Spc29 and Spc42 to the N-terminus of the bridge protein Sfi1 facilitated by centrin initiates dSPB assembly.
Rüthnick D +3 more
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The Mitotic Exit Network Regulates Spindle Pole Body Selection During Sporulation of Saccharomyces cerevisiae. [PDF]
Genetics, 2017 Renicke C +4 more
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Spindle pole body component 25 regulates stemness of prostate cancer cells. [PDF]
Aging (Albany NY), 2018 Spindle pole body component 25 (SPC25) is a component of NDC80 complex that controls spindle assembly checkpoint in the microtubule-binding domain of kinetochores. We recently showed that SPC25 is required for prostate cancer (PrC) cell proliferation and
Cui F, Tang H, Tan J, Hu J.
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Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body. [PDF]
Cells, 2018 The main microtubule organizing centre in the unicellular model organisms Saccharomyces cerevisiae and Schizosaccharomyces pompe is the spindle pole body (SPB). The SPB is a multilayer structure, which duplicates exactly once per cell cycle.
Rüthnick D, Schiebel E.
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Characterization of spindle pole body duplication reveals a regulatory role for nuclear pore complexes. [PDF]
J Cell Biol, 2017 The spindle pole body (SPB) of budding yeast duplicates once per cell cycle. In G1, the satellite, an SPB precursor, assembles next to the mother SPB (mSPB) on the cytoplasmic side of the nuclear envelope (NE).
Rüthnick D +6 more
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