Optogenetic methods to stimulate gamma motor neuron axons ex vivo
Experimental Physiology, EarlyView.Abstract It is challenging to stimulate gamma motor neurons, which are important regulators of muscle spindle afferent function, without also recruiting alpha motor neurons. Here, we test the feasibility of stimulating gamma motor neuron axons using optogenetics in two transgenic mouse lines. We used an ex vivo muscle–nerve preparation in adult mice to
Apoorva Karekal +7 more
wiley +1 more source
The spindle pole-body localization of activated cytoplasmic dynein is cell cycle-dependent in Aspergillus nidulans. [PDF]
Fungal Genet Biol, 2021 Bieger BD, Osmani AH, Xiang X, Egan MJ.
europepmc +1 more source
Calcium regulation of muscle spindle mechanosensory afferent function
Experimental Physiology, EarlyView.Abstract Extracellular calcium is crucial for the normal function of muscle spindle sensory afferents. They express multiple calcium buffering proteins. Extracellular calcium is essential for recycling of synaptic‐like vesicles (SLVs) in the terminals and for the stretch‐evoked inward calcium current of the receptor potential.
Anna Simon +5 more
wiley +1 more source
Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex [PDF]
, 2001 Gislene Pereira
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Two New Cases Expand the Phenotypic Spectrum of TUBG1 Missense Variants
American Journal of Medical Genetics Part A, Volume 197, Issue 9, September 2025.ABSTRACT The gamma‐tubulin ring complex (γ‐TuRC) plays a role in coordinating centrosome and spindle pole body formation during cell division. TUBG1 encodes a critical component of the γ‐TuRC. Pathogenic TUBG1 variants can cause a range of alterations in cortical gyral patterning, microcephaly, and other neurological manifestations.
Roser Urreizti +12 more
wiley +1 more source
SPO21Is Required for Meiosis-specific Modification of the Spindle Pole Body in Yeast [PDF]
, 2001 Bethany K. Bajgier +3 more
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PARP (Poly ADP‐ribose Polymerase) Family in Health and Disease
MedComm, Volume 6, Issue 9, September 2025.PARP family orchestrates ADP‐ribosylation to regulate genomic stability (DNA repair, telomeres) and metabolism (NAD⁺, glucose/lipid). Physiological roles sustain health; dysregulation drives pathologies: cancer (DNA repair addiction), neurodegeneration (parthanatos), cardiovascular disorders (hypertrophy/fibrosis), inflammation (dual role), and viral ...
Pengyuan Lei +9 more
wiley +1 more source
Mitotic Exit Network Controls the Localization of Cdc14 to the Spindle Pole Body in Saccharomyces cerevisiae [PDF]
, 2002 Satoshi Yoshida +2 more
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Journal of Microscopy, Volume 299, Issue 3, Page 242-267, September 2025.Abstract Until recently, the lack of three‐dimensional visualisation of whole cells at the electron microscopic (EM) level has led to a significant gap in our understanding of the interaction of cellular organelles and their interconnection. This is particularly true with regard to the role of the endoplasmic reticulum (ER).
Gerhard Wanner +2 more
wiley +1 more source
Fission Yeast Mutants Affecting Telomere Clustering and Meiosis-Specific Spindle Pole Body Integrity [PDF]
, 2002 Ye Jin, Satoru Uzawa, W. Zacheus Cande
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