Results 181 to 190 of about 110,511 (285)

Papillary and ductal patterns of mesonephric‐like adenocarcinomas are often overlooked: a retrospective revaluation of over 1000 endometrial carcinomas

open access: yesHistopathology, Volume 86, Issue 6, Page 862-877, May 2025.
Mesonephric‐like adenocarcinomas can be misclassified as other Müllerian carcinomas. Papillary (A, B), mixed papillary/ductal (C) or ductal (D) patterns can be overlooked. Aims Mesonephric‐like adenocarcinoma (MLA) of the endometrium is often a diagnostic challenge, due to its morphological resemblance to other more common Müllerian neoplasms.
Ardalan Akbari   +13 more
wiley   +1 more source

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti‐tumoral compounds

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1092-1116, April 2025.
FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana   +17 more
wiley   +1 more source

Search for germline gene variants in colorectal cancer families presenting with multiple primary colorectal cancers

open access: yesInternational Journal of Cancer, Volume 156, Issue 7, Page 1393-1403, 1 April 2025.
What's new? A double primary colorectal cancer case in a familial setting signals a high risk of colorectal cancer. Here, the authors performed whole‐exome sequencing in nine patients with a double primary cancer and a family history of colorectal cancer to identify novel predisposition genes.
Asta Försti   +4 more
wiley   +1 more source

Conservative treatments of bone marrow lesions

open access: yesJournal of Experimental Orthopaedics, Volume 12, Issue 2, April 2025.
Abstract Purpose Bone marrow lesions (BMLs) of the knee are a common magnetic resonance imaging finding and are present in a wide range of pathologies, including traumatic contusions and fractures, following cartilage surgery alterations, osteoarthritis, transient BMLs syndromes, subchondral insufficiency fractures of the knee and spontaneous ...
Luca Andriolo   +8 more
wiley   +1 more source

Yeast Spindle Pole Body Components

open access: yesCold Spring Harbor Symposia on Quantitative Biology, 1991
John V. Kilmartin, Michael P. Rout
openaire   +3 more sources

Ovarian Endometrioma Disrupts Oocyte‐Cumulus Communication and Mitochondrial Function, With Melatonin Mitigating the Effects

open access: yesCell Proliferation, Volume 58, Issue 4, April 2025.
Diagram illustrating the impact of OEM on oocyte‐cumulus communication, showing reduced TZPs, mitochondrial dysfunction, increased oxidative stress, DNA damage, and apoptosis. Melatonin (MLT) treatment improves communication, enhances mitochondrial function, reduces DNA damage, and restores oocyte quality, offering insights into potential therapeutic ...
Lei Ge   +11 more
wiley   +1 more source

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