Centrosome Remodelling in Evolution
Cells, 2018 The centrosome is the major microtubule organizing centre (MTOC) in animal cells. The canonical centrosome is composed of two centrioles surrounded by a pericentriolar matrix (PCM).
Daisuke Ito, Mónica Bettencourt-Dias
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Duplication of the Yeast Spindle Pole Body Once per Cell Cycle. [PDF]
Mol Cell Biol, 2016 The yeast spindle pole body (SPB) is the functional equivalent of the mammalian centrosome. Centrosomes and SPBs duplicate exactly once per cell cycle by mechanisms that use the mother structure as a platform for the assembly of the daughter. The conserved Sfi1 and centrin proteins are essential components of the SPB duplication process.
Rüthnick D, Schiebel E.
europepmc +4 more sources
A casein kinase 1 prevents expulsion of the oocyte meiotic spindle into a polar body by regulating cortical contractility. [PDF]
, 2017 During female meiosis, haploid eggs are generated from diploid oocytes. This reduction in chromosome number occurs through two highly asymmetric cell divisions, resulting in one large egg and two small polar bodies.
Flynn, Jonathan R, McNally, Francis J
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Dynactin-dependent cortical dynein and spherical spindle shape correlate temporally with meiotic spindle rotation in Caenorhabditis elegans. [PDF]
, 2015 Oocyte meiotic spindles orient with one pole juxtaposed to the cortex to facilitate extrusion of chromosomes into polar bodies. In Caenorhabditis elegans, these acentriolar spindles initially orient parallel to the cortex and then rotate to the ...
Andaya, Armann +9 more
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Activation of ADF/cofilin by phosphorylation-regulated Slingshot phosphatase is required for the meiotic spindle assembly in Xenopus laevis oocytes [PDF]
, 2013 We identify Xenopus ADF/cofilin (XAC) and its activator, Slingshot phosphatase (XSSH), as key regulators of actin dynamics essential for spindle microtubule assembly during Xenopus oocyte maturation.
Abe, Hiroshi +9 more
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A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells. [PDF]
, 2014 Dynamic instability, polarity, and spatiotemporal organization are hallmarks of the microtubule cytoskeleton that allow formation of complex structures such as the eukaryotic spindle. No similar structure has been identified in prokaryotes.
Agard, David A +6 more
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Purification of Fluorescently Labeled Saccharomyces cerevisiae Spindle Pole Bodies [PDF]
, 2016 Centrosomes are components of the mitotic spindle responsible for organizing microtubules and establishing a bipolar spindle for accurate chromosome segregation. In budding yeast, Saccharomyces cerevisiae, the centrosome is called the spindle pole body, a highly organized trilaminar structure embedded in the nuclear envelope.
Kimberly K, Fong +2 more
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An updated view on the centrosome as a cell cycle regulator
Cell Division, 2022 The centrosome is a multifunctional organelle that is known primarily for its microtubule organising function. Centrosomal defects caused by changes in centrosomal structure or number have been associated with human diseases ranging from congenital ...
Muyang Lin +2 more
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DSK1, a novel kinesin-related protein from the diatom Cylindrotheca fusiformis that is involved in anaphase spindle elongation. [PDF]
, 1996 We have identified an 80-kD protein that is involved in mitotic spindle elongation in the diatom Cylindrotheca fusiformis. DSK1 (Diatom Spindle Kinesin 1) was isolated using a peptide antibody raised against a conserved region in the motor domain of the ...
Brady, B +3 more
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TheSaccharomyces cerevisiaeSpindle Pole Body Is a Dynamic Structure [PDF]
Molecular Biology of the Cell, 2003 During spindle pole body (SPB) duplication, the new SPB is assembled at a distinct site adjacent to the old SPB. Using quantitative fluorescence methods, we studied the assembly and dynamics of the core structural SPB component Spc110p. The SPB core exhibits both exchange and growth in a cell cycle-dependent manner.
Tennessee J, Yoder +3 more
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