eLife, 2020 Asymmetric astral microtubule organization drives the polarized orientation of the S. cerevisiae mitotic spindle and primes the invariant inheritance of the old spindle pole body (SPB, the yeast centrosome) by the bud.
Marco Geymonat +6 more
doaj +1 more source
The Role of Actin in Spindle Orientation Changes during the Saccharomyces cerevisiae Cell Cycle [PDF]
, 1999 In the budding yeast Saccharomyces cerevisiae, the mitotic spindle must align along the mother-bud axis to accurately partition the sister chromatids into daughter cells.
Adams +45 more
core +3 more sources
A Taz1- and Microtubule-Dependent Regulatory Relationship between Telomere and Centromere Positions in Bouquet Formation Secures Proper Meiotic Divisions. [PDF]
PLoS Genetics, 2016 During meiotic prophase, telomeres cluster, forming the bouquet chromosome arrangement, and facilitate homologous chromosome pairing. In fission yeast, bouquet formation requires switching of telomere and centromere positions.
Kazuhiro Katsumata +8 more
doaj +1 more source
Kinetics of spindle pole body separation in budding yeast. [PDF]
Proceedings of the National Academy of Sciences, 1995 In the budding yeast Saccharomyces cerevisiae, the spindle pole body (SPB) serves as the microtubule-organizing center and is the functional analog of the centrosome of higher organisms. By expressing a fusion of a yeast SPB-associated protein to the Aequorea victoria green fluorescent protein, the movement of the SPBs in living yeast cells undergoing ...
Pamela A. Silver +2 more
openaire +2 more sources
Cystathionine β‐synthase is required for oocyte quality by ensuring proper meiotic spindle assembly
Cell Proliferation, Volume 55, Issue 12, December 2022., 2022 CBS is required for oocyte quality by ensuring proper spindle assembly. During oocyte meiotic maturation, CBS ensures spindle assembly by participating in the acetylation of α‐tubulin to stabilize microtubules. Kinetochores remain attached by spindle microtubules. SAC is removed from the kinetochores and then the chromosomes can be separated correctly.
Yan Cao +9 more
wiley +1 more source
Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis. [PDF]
PLoS ONE, 2009 In mitosis, the spindle assembly checkpoint (SAC) prevents anaphase onset until all chromosomes have been attached to the spindle microtubules and aligned correctly at the equatorial metaphase plate.
Mo Li +6 more
doaj +1 more source
A casein kinase 1 prevents expulsion of the oocyte meiotic spindle into a polar body by regulating cortical contractility. [PDF]
, 2017 During female meiosis, haploid eggs are generated from diploid oocytes. This reduction in chromosome number occurs through two highly asymmetric cell divisions, resulting in one large egg and two small polar bodies.
Flynn, Jonathan R, McNally, Francis J
core +1 more source
Perturbing Microtubule Integrity Blocks AMP-Activated Protein Kinase-Induced Meiotic Resumption in Cultured Mouse Oocytes [PDF]
, 2012 The oocyte meiotic spindle is comprised of microtubules (MT) that bind chromatin and regulate both metaphase plate formation and karyokinesis during meiotic maturation; however, little information is known about their role in meiosis reinitiation.
Downs, Stephen, Ya, Ru
core +2 more sources
Centrosome Remodelling in Evolution
Cells, 2018 The centrosome is the major microtubule organizing centre (MTOC) in animal cells. The canonical centrosome is composed of two centrioles surrounded by a pericentriolar matrix (PCM).
Daisuke Ito, Mónica Bettencourt-Dias
doaj +1 more source
Identification of the augmin complex in the filamentous fungus Aspergillus nidulans. [PDF]
PLoS ONE, 2014 Augmin is a protein complex that binds to spindle microtubules (MTs), recruits the potent MT nucleator, γ-tubulin, and thereby promotes the centrosome-independent MT generation within mitotic and meiotic spindles.
Tomoya Edzuka +4 more
doaj +1 more source