Spiperone Stimulates Regeneration in Pulmonary Endothelium Damaged by Cigarette Smoke and Lipopolysaccharide [PDF]
International Journal of Chronic Obstructive Pulmonary Disease, 2021 Endothelial dysfunction and destruction of the pulmonary microcirculation are important pathogenic factors in chronic obstructive pulmonary disease (COPD). In COPD, bronchial obstruction is associated with endothelial dysfunction. Thus, new pharmacological treatment options aimed at restoring the pulmonary endothelium represent a clinical need in COPD ...
Evgenii Skurikhin +12 more
doaj +7 more sources
High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling [PDF]
Frontiers in Public Health, 2023 BackgroundPrevious research has outlined the health benefits of exercise including its therapeutic potential for substance use disorders (SUD). These data have already been utilized and it is now common to find exercise as part of SUD treatment and ...
John Tyler +14 more
doaj +2 more sources
A molecular basis for selective antagonist destabilization of dopamine D3 receptor quaternary organization [PDF]
Scientific Reports, 2017 The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a ...
Caltabiano, Gianluigi +6 more
core +3 more sources
EFFECTS OF SPIPERONE ON SELF‐STIMULATION AND OTHER ACTIVITIES OF THE MONGOLIAN GERBIL [PDF]
British Journal of Pharmacology, 1978 Self‐stimulation to lever pressing and capacitance probe touching was obtained in Mongolian gerbils (Meriones unguiculatus) from electrode placements within the medial forebrain bundle. Lever pressing was more sensitive to the decremental effects of a central depressant, pentobarbitone, than capacitance probe touching, suggesting its greater ...
E. Marley, N. Francis, J. D. Stephenson
openaire +4 more sources
Unveiling and validating biomarkers related to the IL-10 family in chronic sinusitis with nasal polyps: insights from transcriptomics and single-cell RNA sequencing analysis [PDF]
Frontiers in Molecular BiosciencesIntroductionExtensive efforts have been made to explore members of the IL-10 family as potential therapeutic strategies for various diseases; however, their biological role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains underexplored ...
Xinghong Liu +5 more
doaj +2 more sources
Insights into the mechanism by which atropine inhibits myopia: evidence against cholinergic hyperactivity and modulation of dopamine release [PDF]
British Journal of Pharmacology, Volume 178, Issue 22, Page 4501-4517, November 2021., 2021 Background and Purpose The ability of the muscarinic cholinergic antagonist atropine to inhibit myopia development in humans and animal models would suggest that cholinergic hyperactivity may underlie myopic growth. To test this, we investigated whether cholinergic agonists accelerate ocular growth rates in chickens.
Kate Thomson +4 more
wiley +2 more sources
[3H]-Spiperone Competition Binding to Dopamine D2, D3 and D4 Receptors [PDF]
Bio-Protocol, 2013 This protocol is intended for use in 96 well plates (1,200 μl wells) but it can similarly be applied to standard test tubes (Levant, 2007). D2, D3, and D4 dopamine receptors are members of the D2-like class of dopamine receptors.
Jan-Peter Wieringen, Martin Michel
doaj +2 more sources
Verification of the role of spiperone in the treatment of COPD through bioinformatics analysis
International Immunopharmacology, 2021 Aim of this study is investigates the influence of spiperone on hydrolase activity pathway in chronic obstructive pulmonary disease (COPD).Differentially expressed genes (DEGs) were calculated by the limma package from microarray data GSE20257, and analysed via gene set enrichment analysis (GSEA) for identifying COPD related pathways. The regulation of
Xiaoning Zhong +4 more
openaire +3 more sources
Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks [PDF]
, 2010 .In the avian forebrain, the medial striatum and the intermediate medial mesopallium are thought to be important structures for associative learning in chicks, where the role of dopaminergic systems in learning processes has been verified in various ...
He, Xingu, Nan Sui, Sui, Nan, Xiao, Lin
core +2 more sources
Aquaculture ReportsIn this study, we further investigate the hypothesis that serotonin plus spiperone (Ser+Spi) injection induces ovarian maturation and releases ovarian maturation inducing pheromones into the water, thereby stimulating neighboring untreated females ...
Isabel Quesada-Ávila +5 more
doaj +2 more sources